BE904885A - Procede de deprotection des esters et ethers allyliques. - Google Patents

Procede de deprotection des esters et ethers allyliques.

Info

Publication number
BE904885A
BE904885A BE0/216754A BE216754A BE904885A BE 904885 A BE904885 A BE 904885A BE 0/216754 A BE0/216754 A BE 0/216754A BE 216754 A BE216754 A BE 216754A BE 904885 A BE904885 A BE 904885A
Authority
BE
Belgium
Prior art keywords
palladium
ethers
deprotection
allyl
carboxylic acid
Prior art date
Application number
BE0/216754A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904885A publication Critical patent/BE904885A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procédé de déprotection d'esters et d'éthers allyliques. Ce procédé consiste à faire réagir un ester allylique d'un acide carboxylique ou un éther allylique d'un phénol avec la pyrrolidine ou la pipéridine et une quantité catalytique d'un complexe de palladium organique soluble possédant un ligand de phosphine de coordination pour séparer le radical allylique. On récupère ensuite l'acide carboxylique ou le phénol qui en résulte. Avantageusement, le complexe organique du palladium possédant un ligand de phosphine de coordination est le tétrakis(triphénylphosphine)palladium (0).
BE0/216754A 1985-06-07 1986-06-06 Procede de deprotection des esters et ethers allyliques. BE904885A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/742,495 US4788282A (en) 1985-06-07 1985-06-07 Deprotection of allylic esters and ethers

Publications (1)

Publication Number Publication Date
BE904885A true BE904885A (fr) 1986-12-08

Family

ID=24985064

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216754A BE904885A (fr) 1985-06-07 1986-06-06 Procede de deprotection des esters et ethers allyliques.

Country Status (35)

Country Link
US (1) US4788282A (fr)
JP (1) JPH0637496B2 (fr)
KR (1) KR900007246B1 (fr)
CN (1) CN1015104B (fr)
AR (1) AR241019A1 (fr)
AT (1) AT390955B (fr)
BE (1) BE904885A (fr)
CA (1) CA1273630A (fr)
CH (1) CH666678A5 (fr)
CS (1) CS265220B2 (fr)
DD (1) DD245433A5 (fr)
DE (1) DE3619200C2 (fr)
DK (1) DK268886A (fr)
EG (1) EG18276A (fr)
ES (1) ES8800684A1 (fr)
FI (1) FI89486C (fr)
FR (1) FR2583038B1 (fr)
GB (1) GB2176478B (fr)
GR (1) GR861432B (fr)
HU (1) HU198167B (fr)
IE (1) IE59187B1 (fr)
IL (1) IL79023A (fr)
IT (1) IT1190041B (fr)
LU (1) LU86461A1 (fr)
NL (1) NL191787C (fr)
NO (1) NO165998C (fr)
NZ (1) NZ216364A (fr)
OA (1) OA08340A (fr)
PT (1) PT82727B (fr)
SE (1) SE469076B (fr)
SU (1) SU1508959A3 (fr)
YU (1) YU45330B (fr)
ZA (1) ZA862749B (fr)
ZM (1) ZM3786A1 (fr)
ZW (1) ZW9286A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
JPS63154628A (ja) * 1986-12-17 1988-06-27 Nippon Zeon Co Ltd 保護化アルコール化合物の脱保護方法
EP0384732A3 (fr) * 1989-02-23 1991-12-04 Merck & Co. Inc. Procédé de déblocage d'esters allyliques avec pd (O) supporté par un polymère et régénérable
FR2690153A1 (fr) * 1992-04-15 1993-10-22 Rhone Poulenc Chimie Réactif et procédé catalytique utile pour cliver une fonction protégée.
IL105392A (en) * 1992-04-15 1998-02-22 Rhone Poulenc Chimie Reagent and catalytic process useful for cleaving a protected functional group
US5587474A (en) * 1992-06-18 1996-12-24 Tanabe Seiyaku Co., Ltd. Method for removing the protecting group for carboxyl group
JP2847693B2 (ja) * 1992-06-18 1999-01-20 田辺製薬株式会社 カルボキシル基保護基の除去方法
US5578740A (en) * 1994-12-23 1996-11-26 The Dow Chemical Company Process for preparation of epoxy compounds essentially free of organic halides
WO2006060803A2 (fr) * 2004-12-03 2006-06-08 Polnox Corporation Processus a un seul recipient pour fabriquer des antioxydants polymeres
US8361802B2 (en) * 2009-03-09 2013-01-29 University of Pittsburgh—of the Commonwealth System of Higher Education Fluorescent ozone sensor
US8550716B2 (en) 2010-06-22 2013-10-08 S.C. Johnson & Son, Inc. Tactile enhancement mechanism for a closure mechanism
US8974118B2 (en) 2010-10-29 2015-03-10 S.C. Johnson & Son, Inc. Reclosable bag having a sound producing zipper
US9327875B2 (en) 2010-10-29 2016-05-03 S.C. Johnson & Son, Inc. Reclosable bag having a loud sound during closing
US11180286B2 (en) 2010-10-29 2021-11-23 S. C. Johnson & Son, Inc. Reclosable bag having a loud sound during closing
US8469593B2 (en) 2011-02-22 2013-06-25 S.C. Johnson & Son, Inc. Reclosable bag having a press-to-vent zipper
US8568031B2 (en) 2011-02-22 2013-10-29 S.C. Johnson & Son, Inc. Clicking closure device for a reclosable pouch
WO2014194361A1 (fr) * 2013-06-04 2014-12-11 The University Of Sydney Ligature peptidique
US10294423B2 (en) 2013-11-22 2019-05-21 Polnox Corporation Macromolecular antioxidants based on dual type moiety per molecule: structures, methods of making and using the same
JP6894498B2 (ja) * 2016-08-12 2021-06-30 ザ カトリック ユニバーシティ オブ コリア インダストリー−アカデミック コーオペレイション ファウンデーション 軟組織硬化用組成物
WO2018160879A2 (fr) 2017-03-01 2018-09-07 Polnox Corporation Structures d'inhibiteurs de corrosion macromoléculaire (mcin), leurs procédés de fabrication et d'utilisation
CN108383848A (zh) * 2018-03-27 2018-08-10 石家庄蒎格医药科技有限公司 聚乙二醇纳洛酮新杂质及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314942A (en) * 1979-01-10 1982-02-09 Schering Corporation Deprotection of allylic esters, carbonates and carbamates catalyzed by palladium compounds
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
DE3443993A1 (de) * 1984-12-01 1986-06-05 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von neuen indolderivaten und deren verwendung

Also Published As

Publication number Publication date
AU5808786A (en) 1986-12-11
NL8601469A (nl) 1987-01-02
FI89486B (fi) 1993-06-30
LU86461A1 (fr) 1987-01-13
SE469076B (sv) 1993-05-10
AT390955B (de) 1990-07-25
DE3619200C2 (de) 1994-09-15
SE8602555L (sv) 1986-12-08
ZA862749B (en) 1986-11-26
EG18276A (en) 1993-10-30
NO862237L (no) 1986-12-08
DK268886D0 (da) 1986-06-06
IT8620691A1 (it) 1987-12-05
FI862377A (fi) 1986-12-08
IL79023A (en) 1991-08-16
IL79023A0 (en) 1986-09-30
KR870000336A (ko) 1987-02-17
ATA155586A (de) 1990-01-15
FI89486C (fi) 1993-10-11
AR241019A2 (es) 1991-04-30
DD245433A5 (de) 1987-05-06
NL191787C (nl) 1996-08-02
PT82727A (en) 1986-07-01
KR900007246B1 (ko) 1990-10-06
CN86103521A (zh) 1987-02-04
HUT41006A (en) 1987-03-30
OA08340A (fr) 1988-02-29
FR2583038A1 (fr) 1986-12-12
JPS61286331A (ja) 1986-12-16
PT82727B (pt) 1988-12-15
AR241019A1 (es) 1991-04-30
YU90486A (en) 1987-12-31
IT8620691A0 (it) 1986-06-05
IT1190041B (it) 1988-02-10
IE861514L (en) 1986-12-07
NO165998B (no) 1991-02-04
GB8613738D0 (en) 1986-07-09
IE59187B1 (en) 1994-01-26
GR861432B (en) 1986-10-06
NO862237D0 (no) 1986-06-05
CN1015104B (zh) 1991-12-18
NL191787B (nl) 1996-04-01
CS411986A2 (en) 1989-01-12
NO165998C (no) 1991-05-15
ZW9286A1 (en) 1986-12-03
ES8800684A1 (es) 1987-11-16
DE3619200A1 (de) 1986-12-11
HU198167B (en) 1989-08-28
SU1508959A3 (ru) 1989-09-15
ES555840A0 (es) 1987-11-16
CH666678A5 (de) 1988-08-15
YU45330B (en) 1992-05-28
CA1273630A (fr) 1990-09-04
US4788282A (en) 1988-11-29
GB2176478B (en) 1988-11-30
GB2176478A (en) 1986-12-31
SE8602555D0 (sv) 1986-06-06
JPH0637496B2 (ja) 1994-05-18
DK268886A (da) 1986-12-08
ZM3786A1 (en) 1986-12-29
FR2583038B1 (fr) 1989-05-05
NZ216364A (en) 1989-06-28
CS265220B2 (en) 1989-10-13
AU592342B2 (en) 1990-01-11
FI862377A0 (fi) 1986-06-04

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19970630