BE904867A - Procede de preparation de sels d'heparine: - Google Patents

Procede de preparation de sels d'heparine:

Info

Publication number
BE904867A
BE904867A BE0/216737A BE216737A BE904867A BE 904867 A BE904867 A BE 904867A BE 0/216737 A BE0/216737 A BE 0/216737A BE 216737 A BE216737 A BE 216737A BE 904867 A BE904867 A BE 904867A
Authority
BE
Belgium
Prior art keywords
heparinate
preparation
heparin
cation
phases
Prior art date
Application number
BE0/216737A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of BE904867A publication Critical patent/BE904867A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de préparation de sels d'héparine de pureté pharmacopéique, de préférence d'héparinate de calcium, dans lequel on procède par formation d'un complexe héparine-amine quaternaire, purification et dissolution de ce complexe i) dans une solution aqueuse d'un sel contenant le cation de l'héparinate à préparer, ou ii) dans un solvant organique non miscible ou peu miscible à l'eau, et addition à la solution obtenue d'une solution aqueuse d'un sel contenant le cation de l'héparinate à préparer, attente de la séparation des deux phases et séparation des phases l'une de l'autre et si on le désire, purification de la solution obtenue et précipitation de l'héparinate désiré par addition d'un solvant miscible à l'eau.
BE0/216737A 1985-06-04 1986-06-03 Procede de preparation de sels d'heparine: BE904867A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU852197A HU193769B (en) 1985-06-04 1985-06-04 Sodium-exchanging process for producing pharmaceutically acceptable heparinates applicable even for injections

Publications (1)

Publication Number Publication Date
BE904867A true BE904867A (fr) 1986-10-01

Family

ID=10958239

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216737A BE904867A (fr) 1985-06-04 1986-06-03 Procede de preparation de sels d'heparine:

Country Status (6)

Country Link
AT (1) AT397250B (fr)
BE (1) BE904867A (fr)
FR (1) FR2582657B1 (fr)
GB (1) GB2176200B (fr)
HU (1) HU193769B (fr)
IT (1) IT1190124B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
EP0423151B1 (fr) * 1988-06-03 1993-09-22 ITALFARMACO S.p.A. Sels de glycosaminoglycane, leurs procedes de preparation et compositions pharmaceutiques les contenant

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1013641B (de) * 1956-03-20 1957-08-14 Nordmark Werke Gmbh Verfahren zur Reinigung von Heparin
GB904112A (en) * 1958-12-19 1962-08-22 Roussel Uclaf Improvements in or relating to heparine and derivatives thereof
US2989438A (en) * 1958-12-29 1961-06-20 Roussel Uclaf Process of purifying heparin, and product produced therefrom
US3058884A (en) * 1959-09-14 1962-10-16 Abbott Lab Process for purifying heparin
US3160563A (en) * 1960-05-13 1964-12-08 Ormonoterapia Richter Spa Purification of heaprin
US3342683A (en) * 1964-02-25 1967-09-19 Taiyo Gyogyo Kabushiki Kaisha Heparin from whale tissue and method of preparing same
US3451996A (en) * 1968-02-12 1969-06-24 Thompson Farms Co Method for the preparation of heparin
US3817831A (en) * 1973-01-10 1974-06-18 Wilson Pharm & Chem Corp Process for production of alkali metal salt of heparin
GB2027728B (en) * 1978-08-08 1983-03-30 Choay Sa Physiologically acceptable heparin
IT1141263B (it) * 1980-02-29 1986-10-01 Italfarmaco Spa Metodo per la preparazione di eparinato di calcio

Also Published As

Publication number Publication date
IT1190124B (it) 1988-02-10
IT8620676A0 (it) 1986-06-04
HU193769B (en) 1987-11-30
ATA144386A (de) 1993-07-15
IT8620676A1 (it) 1987-12-04
GB2176200B (en) 1990-01-24
FR2582657A1 (fr) 1986-12-05
GB2176200A (en) 1986-12-17
FR2582657B1 (fr) 1991-12-13
GB8613593D0 (en) 1986-07-09
AT397250B (de) 1994-02-25

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.

Effective date: 19960630