BE900663A - Procede de preparation de 2-hydroxy-5-(1-hydroxy-2-((4-phenyl-2-butyl)-amino)ethyl)benzamide et compositions en contenant. - Google Patents
Procede de preparation de 2-hydroxy-5-(1-hydroxy-2-((4-phenyl-2-butyl)-amino)ethyl)benzamide et compositions en contenant.Info
- Publication number
- BE900663A BE900663A BE0/213712A BE213712A BE900663A BE 900663 A BE900663 A BE 900663A BE 0/213712 A BE0/213712 A BE 0/213712A BE 213712 A BE213712 A BE 213712A BE 900663 A BE900663 A BE 900663A
- Authority
- BE
- Belgium
- Prior art keywords
- hydroxy
- phenyl
- benzamide
- butyl
- ethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- SGUAFYQXFOLMHL-UHFFFAOYSA-N 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide Chemical compound C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 SGUAFYQXFOLMHL-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-phenyl-2-butyl Chemical group 0.000 abstract 1
- WECUIGDEWBNQJJ-UHFFFAOYSA-N 4-phenylbutan-2-amine Chemical compound CC(N)CCC1=CC=CC=C1 WECUIGDEWBNQJJ-UHFFFAOYSA-N 0.000 abstract 1
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229960001632 labetalol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23005/83A IT1194406B (it) | 1983-09-27 | 1983-09-27 | Procedimento per la preparazione di 2-idrossi-5-01-idrossi-2-((4-fenil-2-butil)ammino) etil benzammide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE900663A true BE900663A (fr) | 1985-01-16 |
Family
ID=11202777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/213712A BE900663A (fr) | 1983-09-27 | 1984-09-24 | Procede de preparation de 2-hydroxy-5-(1-hydroxy-2-((4-phenyl-2-butyl)-amino)ethyl)benzamide et compositions en contenant. |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS60105651A (enrdf_load_stackoverflow) |
| BE (1) | BE900663A (enrdf_load_stackoverflow) |
| CH (1) | CH661923A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3435349A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2552427B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2149399B (enrdf_load_stackoverflow) |
| IT (1) | IT1194406B (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017098520A1 (en) * | 2015-12-09 | 2017-06-15 | prscDAVALURI RAMAMOHAN RAO | Process for the preparation of labetalol hydrochloride |
| CN112225674B (zh) * | 2020-10-28 | 2021-12-03 | 天津大学 | 盐酸拉贝洛尔晶型化合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1266058A (enrdf_load_stackoverflow) * | 1969-07-08 | 1972-03-08 | ||
| JPS4843341A (enrdf_load_stackoverflow) * | 1971-10-02 | 1973-06-22 | ||
| ZA794872B (en) * | 1978-09-20 | 1980-11-26 | Schering Corp | A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it |
-
1983
- 1983-09-27 IT IT23005/83A patent/IT1194406B/it active
-
1984
- 1984-09-24 BE BE0/213712A patent/BE900663A/fr not_active IP Right Cessation
- 1984-09-24 GB GB08424100A patent/GB2149399B/en not_active Expired
- 1984-09-25 CH CH4607/84A patent/CH661923A5/it not_active IP Right Cessation
- 1984-09-26 DE DE19843435349 patent/DE3435349A1/de active Granted
- 1984-09-27 JP JP59202903A patent/JPS60105651A/ja active Pending
- 1984-09-27 FR FR8414820A patent/FR2552427B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT8323005A1 (it) | 1985-03-27 |
| IT8323005A0 (it) | 1983-09-27 |
| FR2552427B1 (fr) | 1988-03-25 |
| DE3435349C2 (enrdf_load_stackoverflow) | 1989-09-21 |
| GB8424100D0 (en) | 1984-10-31 |
| DE3435349A1 (de) | 1985-04-18 |
| GB2149399A (en) | 1985-06-12 |
| FR2552427A1 (fr) | 1985-03-29 |
| CH661923A5 (it) | 1987-08-31 |
| IT1194406B (it) | 1988-09-22 |
| JPS60105651A (ja) | 1985-06-11 |
| GB2149399B (en) | 1987-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: SCHARPER PER L INDUSTRIA FARMACEUTICA S.P.A. Effective date: 19900930 |