BE899790A - 3-(3-hydroxybutoxy)-1-butanol et sa preparation. - Google Patents
3-(3-hydroxybutoxy)-1-butanol et sa preparation.Info
- Publication number
- BE899790A BE899790A BE0/213036A BE213036A BE899790A BE 899790 A BE899790 A BE 899790A BE 0/213036 A BE0/213036 A BE 0/213036A BE 213036 A BE213036 A BE 213036A BE 899790 A BE899790 A BE 899790A
- Authority
- BE
- Belgium
- Prior art keywords
- butanol
- preparation
- hydroxybutoxy
- isomers
- pure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/04—Saturated ethers
- C07C43/13—Saturated ethers containing hydroxy or O-metal groups
- C07C43/132—Saturated ethers containing hydroxy or O-metal groups both carbon chains being substituted by hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
On décrit la préparation à l'état pur du 3-(3-hydroxybutyoxy)-1-butanol répondant à la formule I et de ses stéréoisomères et isomères optiques. On décrit également des procédés pour la purification de I et pour la préparation d'un diastéréoisomère pur de I ainsi que des préparations pharmaceutiques contenant comme principe actif le composé I seul ou associé aux éthers isomères 4-(3-hydroxybutoxy)-2-butanol et 3-(3-hydroxy-1-méthylpropoxy)-1-butanol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21352/83A IT1164254B (it) | 1983-05-30 | 1983-05-30 | 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione |
Publications (1)
Publication Number | Publication Date |
---|---|
BE899790A true BE899790A (fr) | 1984-11-30 |
Family
ID=11180528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/213036A BE899790A (fr) | 1983-05-30 | 1984-05-30 | 3-(3-hydroxybutoxy)-1-butanol et sa preparation. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4584321A (fr) |
JP (1) | JPS604146A (fr) |
BE (1) | BE899790A (fr) |
DE (1) | DE3419947A1 (fr) |
ES (1) | ES8507449A1 (fr) |
FR (1) | FR2547813B1 (fr) |
GB (1) | GB2142623B (fr) |
IT (1) | IT1164254B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0534451Y2 (fr) * | 1988-06-20 | 1993-08-31 | ||
MXPA01009893A (es) | 1999-04-01 | 2003-07-28 | Esperion Therapeutics Inc | Compuestos con eter, composiciones y usos de estos. |
JP2004532799A (ja) | 2000-10-11 | 2004-10-28 | エスペリオン セラピューティクス,インコーポレイテッド | コレステロール管理および関連用途のためのスルフィド化合物およびジスルフィド化合物ならびにそれらを含む組成物 |
US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
JP2004511453A (ja) | 2000-10-11 | 2004-04-15 | エスペリオン セラピューティクス,インコーポレイテッド | コレステロールの制御及び関連する使用のためのケトン化合物及び組成物 |
US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
MXPA03003021A (es) | 2000-10-11 | 2003-07-14 | Esperion Therapeutics Inc | Compuestos de eter y composiciones para el control del colesterol y usos relacionados. |
US6673780B2 (en) | 2000-10-11 | 2004-01-06 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
US20050020694A1 (en) * | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
US20040192771A1 (en) * | 2001-10-11 | 2004-09-30 | Dasseux Jean-Louis Henri | Ether compounds and compositions for cholesterol management and related uses |
US20030236213A1 (en) * | 2002-04-10 | 2003-12-25 | Jean-Louis Dasseux | Mimics of acyl coenzyme-A comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses |
HUE036646T2 (hu) * | 2003-01-23 | 2018-07-30 | Esperion Therapeutics Inc | Hidroxilvegyületek és kompozícióik koleszterin szabályozására és kapcsolódó alkalmazásokra |
BR0318685A (pt) * | 2003-12-24 | 2006-12-19 | Esperion Therapeutics Inc | compostos de cetona e composições para controle de colesterol e usos relacionados |
CN103848726B (zh) * | 2012-12-09 | 2017-09-05 | 河北凯盛医药科技有限公司 | 一种高纯度二羟二丁基醚及其制备方法 |
CN103304383B (zh) * | 2013-06-18 | 2015-04-08 | 重庆医科大学 | 保胆健素的新合成方法 |
CN103333057A (zh) * | 2013-06-24 | 2013-10-02 | 大连理工大学 | 一种二羟基二丁醚的制备方法 |
CN103319316B (zh) * | 2013-06-24 | 2015-06-10 | 大连理工大学 | 一种二羟基二丁醚的绿色制备方法 |
CN104230674A (zh) * | 2014-08-28 | 2014-12-24 | 成都邦泽生物医药科技有限公司 | 一种二羟基二丁醚的制备方法 |
US10912751B2 (en) | 2015-03-13 | 2021-02-09 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising ETC1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
AU2020295503A1 (en) | 2019-06-21 | 2022-01-27 | Esperion Therapeutics, Inc. | Salt forms of bempedoic acid and methods for using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT957008B (it) * | 1967-11-09 | 1973-10-10 | Luso Farmaco Inst | Processo per la preparazione di eteri simmetrici di glicoli re canti ossidrili primari e secon dari |
DE2218935C3 (de) * | 1972-04-19 | 1980-01-31 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von wäßrigen Lösungen von N-Vinylpyrrolidonpolymerisaten |
-
1983
- 1983-05-30 IT IT21352/83A patent/IT1164254B/it active Protection Beyond IP Right Term
-
1984
- 1984-04-23 US US06/603,134 patent/US4584321A/en not_active Expired - Lifetime
- 1984-05-03 GB GB08411356A patent/GB2142623B/en not_active Expired
- 1984-05-25 ES ES532802A patent/ES8507449A1/es not_active Expired
- 1984-05-28 DE DE19843419947 patent/DE3419947A1/de active Granted
- 1984-05-28 JP JP59108268A patent/JPS604146A/ja active Granted
- 1984-05-30 FR FR848408571A patent/FR2547813B1/fr not_active Expired
- 1984-05-30 BE BE0/213036A patent/BE899790A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1164254B (it) | 1987-04-08 |
IT8321352A1 (it) | 1984-11-30 |
GB2142623B (en) | 1987-04-15 |
ES532802A0 (es) | 1985-10-01 |
DE3419947C2 (fr) | 1987-11-26 |
GB8411356D0 (en) | 1984-06-06 |
FR2547813B1 (fr) | 1989-01-27 |
JPS6241702B2 (fr) | 1987-09-04 |
FR2547813A1 (fr) | 1984-12-28 |
JPS604146A (ja) | 1985-01-10 |
DE3419947A1 (de) | 1984-12-06 |
GB2142623A (en) | 1985-01-23 |
IT8321352A0 (it) | 1983-05-30 |
ES8507449A1 (es) | 1985-10-01 |
US4584321A (en) | 1986-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE20 | Patent expired |
Owner name: *ISTITUTO LUSO FARMACO D ITALIA S.P.A. Effective date: 20040530 |