BE899790A - 3-(3-hydroxybutoxy)-1-butanol et sa preparation. - Google Patents

3-(3-hydroxybutoxy)-1-butanol et sa preparation.

Info

Publication number
BE899790A
BE899790A BE0/213036A BE213036A BE899790A BE 899790 A BE899790 A BE 899790A BE 0/213036 A BE0/213036 A BE 0/213036A BE 213036 A BE213036 A BE 213036A BE 899790 A BE899790 A BE 899790A
Authority
BE
Belgium
Prior art keywords
butanol
preparation
hydroxybutoxy
isomers
pure
Prior art date
Application number
BE0/213036A
Other languages
English (en)
Inventor
E Manghisi
A Salimbeni
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Publication of BE899790A publication Critical patent/BE899790A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/132—Saturated ethers containing hydroxy or O-metal groups both carbon chains being substituted by hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On décrit la préparation à l'état pur du 3-(3-hydroxybutyoxy)-1-butanol répondant à la formule I et de ses stéréoisomères et isomères optiques. On décrit également des procédés pour la purification de I et pour la préparation d'un diastéréoisomère pur de I ainsi que des préparations pharmaceutiques contenant comme principe actif le composé I seul ou associé aux éthers isomères 4-(3-hydroxybutoxy)-2-butanol et 3-(3-hydroxy-1-méthylpropoxy)-1-butanol.
BE0/213036A 1983-05-30 1984-05-30 3-(3-hydroxybutoxy)-1-butanol et sa preparation. BE899790A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21352/83A IT1164254B (it) 1983-05-30 1983-05-30 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione

Publications (1)

Publication Number Publication Date
BE899790A true BE899790A (fr) 1984-11-30

Family

ID=11180528

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213036A BE899790A (fr) 1983-05-30 1984-05-30 3-(3-hydroxybutoxy)-1-butanol et sa preparation.

Country Status (8)

Country Link
US (1) US4584321A (fr)
JP (1) JPS604146A (fr)
BE (1) BE899790A (fr)
DE (1) DE3419947A1 (fr)
ES (1) ES8507449A1 (fr)
FR (1) FR2547813B1 (fr)
GB (1) GB2142623B (fr)
IT (1) IT1164254B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0534451Y2 (fr) * 1988-06-20 1993-08-31
US6410802B1 (en) 1999-04-01 2002-06-25 Esperion Therapeutics, Inc. Methods for synthesizing ether compounds and intermediates therefor
IL155246A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
EP1326822A2 (fr) 2000-10-11 2003-07-16 Esperion Therapeutics Inc. Composes de fonction cetone et compositions pour la regulation du taux de cholesterol, et utilisations associees
US6713507B2 (en) 2000-10-11 2004-03-30 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CN101426763A (zh) 2000-10-11 2009-05-06 埃斯佩里安医疗公司 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CA2480415A1 (fr) * 2002-04-10 2003-10-23 Esperion Therapeutics, Inc. Derives fonctionnalises a chaine longue utilises comme mimiques d'acyl-coenzyme a et leurs compositions, methodes de regulation du taux de cholesterol et utilisations associees
ES2594340T3 (es) 2003-01-23 2016-12-19 Esperion Therapeutics Inc. Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes
EP1701931B1 (fr) 2003-12-24 2018-10-10 Esperion Therapeutics, Inc. Dérivés cétoniques, compositions pour maintenir le taux de cholèstèrol et leurs utilisations
CN103848726B (zh) * 2012-12-09 2017-09-05 河北凯盛医药科技有限公司 一种高纯度二羟二丁基醚及其制备方法
CN103304383B (zh) * 2013-06-18 2015-04-08 重庆医科大学 保胆健素的新合成方法
CN103333057A (zh) * 2013-06-24 2013-10-02 大连理工大学 一种二羟基二丁醚的制备方法
CN103319316B (zh) * 2013-06-24 2015-06-10 大连理工大学 一种二羟基二丁醚的绿色制备方法
CN104230674A (zh) * 2014-08-28 2014-12-24 成都邦泽生物医药科技有限公司 一种二羟基二丁醚的制备方法
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN112437765A (zh) 2019-06-21 2021-03-02 艾斯柏伦治疗公司 贝派地酸的盐形式及其使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT957008B (it) * 1967-11-09 1973-10-10 Luso Farmaco Inst Processo per la preparazione di eteri simmetrici di glicoli re canti ossidrili primari e secon dari
DE2218935C3 (de) * 1972-04-19 1980-01-31 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von wäßrigen Lösungen von N-Vinylpyrrolidonpolymerisaten

Also Published As

Publication number Publication date
IT8321352A0 (it) 1983-05-30
FR2547813B1 (fr) 1989-01-27
JPS604146A (ja) 1985-01-10
DE3419947C2 (fr) 1987-11-26
JPS6241702B2 (fr) 1987-09-04
ES532802A0 (es) 1985-10-01
DE3419947A1 (de) 1984-12-06
US4584321A (en) 1986-04-22
FR2547813A1 (fr) 1984-12-28
IT8321352A1 (it) 1984-11-30
IT1164254B (it) 1987-04-08
ES8507449A1 (es) 1985-10-01
GB2142623A (en) 1985-01-23
GB8411356D0 (en) 1984-06-06
GB2142623B (en) 1987-04-15

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *ISTITUTO LUSO FARMACO D ITALIA S.P.A.

Effective date: 20040530