BE895708A - Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux - Google Patents

Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux

Info

Publication number
BE895708A
BE895708A BE0/209971A BE209971A BE895708A BE 895708 A BE895708 A BE 895708A BE 0/209971 A BE0/209971 A BE 0/209971A BE 209971 A BE209971 A BE 209971A BE 895708 A BE895708 A BE 895708A
Authority
BE
Belgium
Prior art keywords
ureas
atherosclerus
thio
drugs
preparation process
Prior art date
Application number
BE0/209971A
Other languages
English (en)
French (fr)
Inventor
V G Devries
E E Largis
R B Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of BE895708A publication Critical patent/BE895708A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE0/209971A 1982-01-26 1983-01-26 Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux BE895708A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas

Publications (1)

Publication Number Publication Date
BE895708A true BE895708A (fr) 1983-07-26

Family

ID=23342884

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/209971A BE895708A (fr) 1982-01-26 1983-01-26 Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux

Country Status (6)

Country Link
US (1) US4473579A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58134070A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE895708A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1291990C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH18706A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA83484B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623662A (en) 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
DE3636190A1 (de) * 1986-10-24 1988-04-28 Bayer Ag Verfahren zur herstellung von n,n-diaryl-harnstoffen
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
ES2037768T3 (es) * 1987-07-02 1993-07-01 Warner-Lambert Company Procedimiento para preparar n-(fenil(2,6-disustituido))-ureas y carbamatos inhibidores de acil-coa: colesterol acil-transferasa.
CN1021819C (zh) * 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US4999373A (en) * 1988-03-30 1991-03-12 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
DE3920616A1 (de) * 1989-06-23 1991-01-03 Boehringer Mannheim Gmbh Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate
JPH05310678A (ja) * 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
ATE115558T1 (de) * 1990-03-12 1994-12-15 Yamanouchi Pharma Co Ltd Harnstoffderivate, deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen.
US5106873A (en) * 1990-06-26 1992-04-21 Warner-Lambert Company ACAT inhibitors
US5362878A (en) * 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
US5401825A (en) * 1993-05-05 1995-03-28 Gould Inc. Styrene type monomers containing substituents thereon, e.g. urea, and polymers and copolymers thereof
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
RU2319693C9 (ru) * 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
MXPA02002578A (es) 1999-09-08 2002-10-23 Guilford Pharm Inc Compuestos de union a ciclofilina no peptidicos, y su uso.
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6656971B2 (en) 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2426938T3 (es) * 2001-12-03 2013-10-25 Bayer Healthcare Llc Compuestos de aril urea en combinación con otros agentes citostáticos o citotóxicos para tratar cánceres humanos
SI1580188T1 (sl) * 2002-02-11 2012-02-29 Bayer Healthcare Llc Aril sečnine kot kinazni inhibitorji
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
CN1289467C (zh) * 2002-08-30 2006-12-13 日本烟草产业株式会社 二苄胺化合物及其药物用途
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
US8796250B2 (en) 2003-05-20 2014-08-05 Bayer Healthcare Llc Diaryl ureas for diseases mediated by PDGFR
BRPI0412219B8 (pt) 2003-07-23 2021-07-27 Bayer Healthcare Llc compostos ômega-carboxi aril difenil uréia fluoro substituídos e composições farmacêuticas compreendendo os referidos compostos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1949-12-06
US2867520A (en) * 1956-11-23 1959-01-06 Monsanto Chemicals 1-(chloraryl) 3-alkyl 3-alkynyl urea
US2993930A (en) * 1958-03-18 1961-07-25 Midwest Research Inst Tetra-substituted ureas
US3277061A (en) * 1963-07-01 1966-10-04 Union Oil Co Carbonylation of amines and substituted ureas derived therefrom
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
GB1143802A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-03-25
US3897493A (en) * 1971-09-13 1975-07-29 Stauffer Chemical Co Meta-anilide urea compositions and their utility as herbicides
JPS5224104B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1974-10-07 1977-06-29
JPS5312844A (en) * 1976-07-20 1978-02-04 Nippon Tokushu Noyaku Seizo Kk Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents
DE3027253C2 (de) * 1980-07-18 1982-11-04 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von Wasserstoffperoxid
JPS6032447A (ja) * 1983-08-03 1985-02-19 Nec Corp 群別２線式搬送回線の折返し回路

Also Published As

Publication number Publication date
JPS58134070A (ja) 1983-08-10
JPH0254821B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-11-22
US4473579A (en) 1984-09-25
PH18706A (en) 1985-09-05
CA1291990C (en) 1991-11-12
ZA83484B (en) 1983-10-26

Similar Documents

Publication Publication Date Title
BE895708A (fr) Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux
BE892758A (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
FR2504920B1 (fr) Derives phenylcyclobutyliques, leur procede de preparation et leur application therapeutique
BE878723A (fr) Derives de 4-anilinoquinazoline, leur procede de preparation et leur application en therapeutique
LU80081A1 (fr) Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
BE892270A (fr) Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
FR2509310B1 (fr) Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
FR2532648B1 (fr) Derives de carbostyrile, leur procede de preparation et leur application en therapeutique
BE851893A (fr) Nouvelles aryl-3 oxazolidinones-2, leur procede de preparation et leur application en therapeutique
FR2521134B1 (fr) Urees et thio-urees substituees, leur procede de preparation et leur application therapeutique comme medicaments anti-atherosclereux
FR2522324B1 (fr) Pyrrole-acetamides, leur procede de preparation et composition therapeutique les contenant
FR2458547B2 (fr) Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
MA19331A1 (fr) Derives de la thieno - pyridinone , leur procede de preparation et leur application therapeutique .
FR2506306B1 (fr) Nouveaux derives de l&#39;amidinopiperidine, leur procede de preparation et leur application en therapeutique
FR2549473B1 (fr) Urees et thiourees, leur procede de preparation et leurs applications en therapeutique
BE858356A (fr) Derives d&#39;acide 7-acylamino-8-oxo-3-oxa-1-azabicyclo-(4.2.0)octane-2-carboxylique, leur procede de preparation et leur application en therapeutique
FR2560195B1 (fr) Derives d&#39;alanyl-proline, leur procede de preparation et leurs applications pharmaceutiques
BE883713A (fr) Nouveau derives de carbostyrile, leur procede de preparation et leur application en therapeutique
BE854133A (fr) 1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique
BE854812A (fr) Benzenesulfonylurees, leur procede de preparation et leur application therapeutique
FR2535715B1 (fr) Peptides biologiquement actifs, procede pour leur preparation et leur emploi comme medicaments
FR2624861B1 (fr) Carbamates tricycliques, leur procede de preparation et leur application en therapeutique
FR2520739B1 (fr) Nouveaux derives d&#39;ester indoleacetique, leur procede de preparation et leur application en therapeutique
BE869833A (fr) 2,3-polymethylene-4-oxo-4h-pyrido(1,2-a) pyrimidines utiles comme medicaments et procede pour leur preparation
FR2514768B1 (fr) Derives de phosphoramide, leur procede de preparation et leur application en therapeutique

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AMERICAN CYANAMID CY

Effective date: 19960131