BE891446A - Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-pipzrazinyl) butyl)-8-azaspiro (4,5)-decane-7, 9-dione - Google Patents

Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-pipzrazinyl) butyl)-8-azaspiro (4,5)-decane-7, 9-dione

Info

Publication number
BE891446A
BE891446A BE0/206810A BE206810A BE891446A BE 891446 A BE891446 A BE 891446A BE 0/206810 A BE0/206810 A BE 0/206810A BE 206810 A BE206810 A BE 206810A BE 891446 A BE891446 A BE 891446A
Authority
BE
Belgium
Prior art keywords
pipzrazinyl
azaspiro
decane
dione
pyrimidinyl
Prior art date
Application number
BE0/206810A
Other languages
English (en)
French (fr)
Inventor
R Covington
D Temple Jr
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE891446A publication Critical patent/BE891446A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE0/206810A 1980-12-11 1981-12-11 Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-pipzrazinyl) butyl)-8-azaspiro (4,5)-decane-7, 9-dione BE891446A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21521480A 1980-12-11 1980-12-11

Publications (1)

Publication Number Publication Date
BE891446A true BE891446A (fr) 1982-06-11

Family

ID=22802113

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/206810A BE891446A (fr) 1980-12-11 1981-12-11 Procede de production de 8-(4-(4-(2-pyrimidinyl)-1-pipzrazinyl) butyl)-8-azaspiro (4,5)-decane-7, 9-dione

Country Status (18)

Country Link
JP (1) JPS57122082A (da)
AT (1) AT380686B (da)
AU (1) AU528067B2 (da)
BE (1) BE891446A (da)
CA (1) CA1172255A (da)
CH (1) CH647518A5 (da)
DE (1) DE3149011A1 (da)
DK (1) DK154560C (da)
FI (1) FI73993C (da)
FR (1) FR2496105B1 (da)
GB (1) GB2089341B (da)
GR (1) GR76331B (da)
IE (1) IE51948B1 (da)
IT (1) IT1172073B (da)
LU (1) LU83833A1 (da)
NL (1) NL8105529A (da)
SE (1) SE444438B (da)
YU (1) YU42432B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2341925A1 (de) * 1973-08-20 1975-03-06 Thomae Gmbh Dr K Neue pyrimidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPH0113476B2 (da) 1989-03-06
IE51948B1 (en) 1987-04-29
FI813937L (fi) 1982-06-12
DE3149011C2 (da) 1988-08-25
SE444438B (sv) 1986-04-14
IE812897L (en) 1982-06-11
SE8107446L (sv) 1982-06-12
FR2496105A1 (fr) 1982-06-18
DK154560B (da) 1988-11-28
FI73993B (fi) 1987-08-31
YU42432B (en) 1988-08-31
GR76331B (da) 1984-08-04
ATA529581A (de) 1985-11-15
FR2496105B1 (fr) 1985-12-13
DE3149011A1 (de) 1982-07-15
CH647518A5 (de) 1985-01-31
DK154560C (da) 1989-04-17
CA1172255A (en) 1984-08-07
JPS57122082A (en) 1982-07-29
AT380686B (de) 1986-06-25
DK548081A (da) 1982-06-12
GB2089341A (en) 1982-06-23
AU7604181A (en) 1982-07-15
IT1172073B (it) 1987-06-18
GB2089341B (en) 1984-09-19
NL8105529A (nl) 1982-07-01
IT8149718A0 (it) 1981-11-16
FI73993C (fi) 1987-12-10
AU528067B2 (en) 1983-04-14
YU243681A (en) 1984-02-29
LU83833A1 (fr) 1982-07-07

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: BRISTOL-MYERS CY

Effective date: 20011211