BE891446A - PROCESS FOR THE PRODUCTION OF 8- (4- (4- (2-PYRIMIDINYL) -1-PIPZRAZINYL) BUTYL) -8-AZASPIRO (4,5) -DECANE-7, 9-DIONE - Google Patents
PROCESS FOR THE PRODUCTION OF 8- (4- (4- (2-PYRIMIDINYL) -1-PIPZRAZINYL) BUTYL) -8-AZASPIRO (4,5) -DECANE-7, 9-DIONEInfo
- Publication number
- BE891446A BE891446A BE0/206810A BE206810A BE891446A BE 891446 A BE891446 A BE 891446A BE 0/206810 A BE0/206810 A BE 0/206810A BE 206810 A BE206810 A BE 206810A BE 891446 A BE891446 A BE 891446A
- Authority
- BE
- Belgium
- Prior art keywords
- pipzrazinyl
- azaspiro
- decane
- dione
- pyrimidinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21521480A | 1980-12-11 | 1980-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE891446A true BE891446A (en) | 1982-06-11 |
Family
ID=22802113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/206810A BE891446A (en) | 1980-12-11 | 1981-12-11 | PROCESS FOR THE PRODUCTION OF 8- (4- (4- (2-PYRIMIDINYL) -1-PIPZRAZINYL) BUTYL) -8-AZASPIRO (4,5) -DECANE-7, 9-DIONE |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS57122082A (en) |
AT (1) | AT380686B (en) |
AU (1) | AU528067B2 (en) |
BE (1) | BE891446A (en) |
CA (1) | CA1172255A (en) |
CH (1) | CH647518A5 (en) |
DE (1) | DE3149011A1 (en) |
DK (1) | DK154560C (en) |
FI (1) | FI73993C (en) |
FR (1) | FR2496105B1 (en) |
GB (1) | GB2089341B (en) |
GR (1) | GR76331B (en) |
IE (1) | IE51948B1 (en) |
IT (1) | IT1172073B (en) |
LU (1) | LU83833A1 (en) |
NL (1) | NL8105529A (en) |
SE (1) | SE444438B (en) |
YU (1) | YU42432B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU212301B (en) * | 1989-04-28 | 1996-05-28 | Alkaloida Vegyeszeti Gyar | Process for producing buspirone |
US5631017A (en) * | 1993-03-26 | 1997-05-20 | Beth Israel Deaconess Medical Center, Inc. | Topical application of buspirone for treatment of pathological conditions associated with immune responses |
US5484788A (en) * | 1993-03-26 | 1996-01-16 | Beth Israel Hospital Association | Buspirone as a systemic immunosuppressant |
KR950014099A (en) * | 1993-11-10 | 1995-06-15 | 장기하 | Method for preparing N- (2-pyrimidyl) piperazinyl butylamide |
US5637314A (en) * | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (en) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | HETEROCYCLICAL AZASPIRODECANEDIONES AND METHODS FOR THEIR PREPARATION |
DE2341925A1 (en) * | 1973-08-20 | 1975-03-06 | Thomae Gmbh Dr K | 2,4, (opt.5-), 6-substd. pyriminidines as antithrombic agents - e.g. 6-methyl-5-nitro-2-piperazino-4-thiomorpolino-pyrimidine |
-
1981
- 1981-09-29 CA CA000386889A patent/CA1172255A/en not_active Expired
- 1981-10-05 AU AU76041/81A patent/AU528067B2/en not_active Expired
- 1981-10-09 YU YU2436/81A patent/YU42432B/en unknown
- 1981-10-27 GB GB8132370A patent/GB2089341B/en not_active Expired
- 1981-11-16 IT IT49718/81A patent/IT1172073B/en active
- 1981-11-27 GR GR66636A patent/GR76331B/el unknown
- 1981-12-08 FI FI813937A patent/FI73993C/en not_active IP Right Cessation
- 1981-12-08 CH CH7842/81A patent/CH647518A5/en not_active IP Right Cessation
- 1981-12-08 NL NL8105529A patent/NL8105529A/en active Search and Examination
- 1981-12-08 FR FR8122916A patent/FR2496105B1/en not_active Expired
- 1981-12-09 JP JP56197037A patent/JPS57122082A/en active Granted
- 1981-12-10 IE IE2897/81A patent/IE51948B1/en not_active IP Right Cessation
- 1981-12-10 DE DE19813149011 patent/DE3149011A1/en active Granted
- 1981-12-10 DK DK548081A patent/DK154560C/en not_active IP Right Cessation
- 1981-12-10 AT AT0529581A patent/AT380686B/en not_active IP Right Cessation
- 1981-12-11 SE SE8107446A patent/SE444438B/en not_active IP Right Cessation
- 1981-12-11 BE BE0/206810A patent/BE891446A/en not_active IP Right Cessation
- 1981-12-11 LU LU83833A patent/LU83833A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI813937L (en) | 1982-06-12 |
CH647518A5 (en) | 1985-01-31 |
DK154560B (en) | 1988-11-28 |
YU42432B (en) | 1988-08-31 |
DE3149011A1 (en) | 1982-07-15 |
CA1172255A (en) | 1984-08-07 |
IT1172073B (en) | 1987-06-18 |
JPH0113476B2 (en) | 1989-03-06 |
AU528067B2 (en) | 1983-04-14 |
FI73993B (en) | 1987-08-31 |
DE3149011C2 (en) | 1988-08-25 |
GB2089341B (en) | 1984-09-19 |
LU83833A1 (en) | 1982-07-07 |
IE812897L (en) | 1982-06-11 |
AU7604181A (en) | 1982-07-15 |
IT8149718A0 (en) | 1981-11-16 |
GB2089341A (en) | 1982-06-23 |
AT380686B (en) | 1986-06-25 |
DK154560C (en) | 1989-04-17 |
YU243681A (en) | 1984-02-29 |
IE51948B1 (en) | 1987-04-29 |
GR76331B (en) | 1984-08-04 |
JPS57122082A (en) | 1982-07-29 |
NL8105529A (en) | 1982-07-01 |
FI73993C (en) | 1987-12-10 |
FR2496105A1 (en) | 1982-06-18 |
ATA529581A (en) | 1985-11-15 |
SE8107446L (en) | 1982-06-12 |
FR2496105B1 (en) | 1985-12-13 |
DK548081A (en) | 1982-06-12 |
SE444438B (en) | 1986-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE20 | Patent expired |
Owner name: BRISTOL-MYERS CY Effective date: 20011211 |