SE8107446L - NEW PROCEDURE FOR BUSPIRON PREPARATION - Google Patents

NEW PROCEDURE FOR BUSPIRON PREPARATION

Info

Publication number
SE8107446L
SE8107446L SE8107446A SE8107446A SE8107446L SE 8107446 L SE8107446 L SE 8107446L SE 8107446 A SE8107446 A SE 8107446A SE 8107446 A SE8107446 A SE 8107446A SE 8107446 L SE8107446 L SE 8107446L
Authority
SE
Sweden
Prior art keywords
buspiron
preparation
new procedure
busipirone
new
Prior art date
Application number
SE8107446A
Other languages
Swedish (sv)
Other versions
SE444438B (en
Inventor
R R Covington
Jr D L Temple
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8107446L publication Critical patent/SE8107446L/en
Publication of SE444438B publication Critical patent/SE444438B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Abstract

Busipirone of the formula <IMAGE> is prepared in a new process wherein the 2-pyrimidinyl component thereof is introduced in a final alkylation step involving 2-halopyrimidines. Radioactive labelled busipirone can be obtained according to the process by employing 2-chloro- pyrimidine-<14>C 2-chloropyrimidine- <15> N2.
SE8107446A 1980-12-11 1981-12-11 PROCEDURE FOR PREPARING RADIOACTIVALLY LABELED BUSPIRON SE444438B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21521480A 1980-12-11 1980-12-11

Publications (2)

Publication Number Publication Date
SE8107446L true SE8107446L (en) 1982-06-12
SE444438B SE444438B (en) 1986-04-14

Family

ID=22802113

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8107446A SE444438B (en) 1980-12-11 1981-12-11 PROCEDURE FOR PREPARING RADIOACTIVALLY LABELED BUSPIRON

Country Status (18)

Country Link
JP (1) JPS57122082A (en)
AT (1) AT380686B (en)
AU (1) AU528067B2 (en)
BE (1) BE891446A (en)
CA (1) CA1172255A (en)
CH (1) CH647518A5 (en)
DE (1) DE3149011A1 (en)
DK (1) DK154560C (en)
FI (1) FI73993C (en)
FR (1) FR2496105B1 (en)
GB (1) GB2089341B (en)
GR (1) GR76331B (en)
IE (1) IE51948B1 (en)
IT (1) IT1172073B (en)
LU (1) LU83833A1 (en)
NL (1) NL8105529A (en)
SE (1) SE444438B (en)
YU (1) YU42432B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
KR950014099A (en) * 1993-11-10 1995-06-15 장기하 Method for preparing N- (2-pyrimidyl) piperazinyl butylamide
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (en) * 1969-11-24 1971-05-24 Bristol Myers Co HETEROCYCLICAL AZASPIRODECANEDIONES AND METHODS FOR THEIR PREPARATION
DE2341925A1 (en) * 1973-08-20 1975-03-06 Thomae Gmbh Dr K 2,4, (opt.5-), 6-substd. pyriminidines as antithrombic agents - e.g. 6-methyl-5-nitro-2-piperazino-4-thiomorpolino-pyrimidine

Also Published As

Publication number Publication date
JPS57122082A (en) 1982-07-29
FI813937L (en) 1982-06-12
CH647518A5 (en) 1985-01-31
GB2089341B (en) 1984-09-19
BE891446A (en) 1982-06-11
NL8105529A (en) 1982-07-01
FI73993C (en) 1987-12-10
DE3149011C2 (en) 1988-08-25
YU42432B (en) 1988-08-31
AT380686B (en) 1986-06-25
FR2496105B1 (en) 1985-12-13
ATA529581A (en) 1985-11-15
GB2089341A (en) 1982-06-23
IT1172073B (en) 1987-06-18
IT8149718A0 (en) 1981-11-16
CA1172255A (en) 1984-08-07
FI73993B (en) 1987-08-31
GR76331B (en) 1984-08-04
FR2496105A1 (en) 1982-06-18
DE3149011A1 (en) 1982-07-15
SE444438B (en) 1986-04-14
JPH0113476B2 (en) 1989-03-06
LU83833A1 (en) 1982-07-07
DK548081A (en) 1982-06-12
AU528067B2 (en) 1983-04-14
IE51948B1 (en) 1987-04-29
YU243681A (en) 1984-02-29
DK154560C (en) 1989-04-17
IE812897L (en) 1982-06-11
DK154560B (en) 1988-11-28
AU7604181A (en) 1982-07-15

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