BE882305A - Nouveaux composes de benzodiazepine - Google Patents

Nouveaux composes de benzodiazepine

Info

Publication number
BE882305A
BE882305A BE0/199851A BE199851A BE882305A BE 882305 A BE882305 A BE 882305A BE 0/199851 A BE0/199851 A BE 0/199851A BE 199851 A BE199851 A BE 199851A BE 882305 A BE882305 A BE 882305A
Authority
BE
Belgium
Prior art keywords
benzodiazepine compounds
novel benzodiazepine
novel
compounds
benzodiazepine
Prior art date
Application number
BE0/199851A
Other languages
English (en)
French (fr)
Original Assignee
Green Cross Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp filed Critical Green Cross Corp
Publication of BE882305A publication Critical patent/BE882305A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE0/199851A 1979-07-17 1980-03-19 Nouveaux composes de benzodiazepine BE882305A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Publications (1)

Publication Number Publication Date
BE882305A true BE882305A (fr) 1980-07-16

Family

ID=13983232

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/199851A BE882305A (fr) 1979-07-17 1980-03-19 Nouveaux composes de benzodiazepine

Country Status (11)

Country Link
US (1) US4309437A (OSRAM)
JP (1) JPS5615289A (OSRAM)
BE (1) BE882305A (OSRAM)
CA (1) CA1152985A (OSRAM)
CH (1) CH648848A5 (OSRAM)
DE (1) DE3010544C2 (OSRAM)
FR (1) FR2461711A1 (OSRAM)
GB (1) GB2053894B (OSRAM)
LU (1) LU82272A1 (OSRAM)
NL (1) NL8001531A (OSRAM)
SE (1) SE436882B (OSRAM)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214774A (en) * 1983-02-10 1986-12-02 Yusei Shiraga Benzodiazepine derivative
JPS59152329A (ja) * 1983-02-17 1984-08-31 Green Cross Corp:The 局所障害抑制剤
JPS60168512U (ja) * 1985-03-25 1985-11-08 株式会社栗田機械製作所 圧搾濾板の圧搾膜検査装置
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
ES2260570T3 (es) * 1998-08-27 2006-11-01 Spirogen Limited Pirrolobenziodiazepinas dimericas.
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
PT2270010E (pt) * 2004-03-01 2012-03-12 Spirogen Ltd Derivados de 11-hidroxi-5h-pirrolo[2,1-c][1,4]benzodiazepin- 5-ona como intermediários chave para a preparação de pirrolobenzodiazepinas substituídas em c2
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
US7528126B2 (en) * 2004-03-09 2009-05-05 Spirogen Limited Pyrrolobenzodiazepines
BRPI0610284A8 (pt) * 2005-04-21 2017-05-09 Spirogen Ltd Pirrolobenzodiazepinas
GB0813432D0 (en) * 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
CN107019804A (zh) 2010-04-15 2017-08-08 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
MX341524B (es) 2011-09-20 2016-08-24 Medimmune Ltd Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos.
EA027386B1 (ru) 2011-10-14 2017-07-31 Медимьюн Лимитед Пирролобензодиазепины
MX341523B (es) 2011-10-14 2016-08-24 Medimmune Ltd Pirrolobenzodiazepinas.
AU2012322933B2 (en) 2011-10-14 2017-02-02 Medimmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
ES2660233T3 (es) 2011-10-14 2018-03-21 Seattle Genetics, Inc. Pirrolobenzodiazepinas y conjugados dirigidos
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
JP6125614B2 (ja) 2012-04-30 2017-05-10 ユーシーエル ビジネス ピーエルシー ピロロベンゾジアゼピン
SI2906251T1 (en) 2012-10-12 2018-01-31 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
SMT201900017T1 (it) 2012-10-12 2019-02-28 Medimmune Ltd Coniugati pirrolobenzodiazepina-anticorpo
WO2014057072A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
DK2906296T3 (en) 2012-10-12 2018-05-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
CA2941485C (en) 2012-10-12 2018-06-12 Philip Wilson Howard Pyrrolobenzodiazepines and conjugates thereof
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
CN110256469B (zh) 2012-10-12 2022-05-17 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其结合物
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
PL2906253T3 (pl) 2012-10-12 2019-02-28 Adc Therapeutics Sa Koniugaty pirolobenzodiazepina-przeciwciało anty-psma
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054983B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
MX379396B (es) 2014-11-25 2025-03-11 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepina y anticuerpo.
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2017201132A2 (en) 2016-05-18 2017-11-23 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
TWI760344B (zh) 2016-06-24 2022-04-11 美商梅爾莎納醫療公司 吡咯並苯並二氮呯類和彼等之共軛物類
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
SMT202100543T1 (it) 2017-02-08 2021-11-12 Adc Therapeutics Sa Coniugati pirrolobenzodiazepina-anticorpo
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
SMT202200490T1 (it) 2017-04-18 2023-01-13 Medimmune Ltd Coniugati di pirrolobenzodiazepina
US20200129637A1 (en) 2017-04-20 2020-04-30 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
EP3638373B1 (en) 2017-06-14 2024-09-04 ADC Therapeutics SA Dosage regimes for the administration of an anti-cd19 adc
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US12209099B2 (en) 2019-03-15 2025-01-28 Medimmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
USD925487S1 (en) * 2019-10-22 2021-07-20 Lg Electronics Inc. Audio player

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523941A (en) * 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

Also Published As

Publication number Publication date
FR2461711A1 (fr) 1981-02-06
NL8001531A (nl) 1981-01-20
GB2053894A (en) 1981-02-11
SE436882B (sv) 1985-01-28
DE3010544C2 (de) 1982-07-01
LU82272A1 (fr) 1980-07-01
JPS6237631B2 (OSRAM) 1987-08-13
DE3010544A1 (de) 1981-01-29
GB2053894B (en) 1983-04-20
FR2461711B1 (OSRAM) 1983-05-13
SE8001458L (sv) 1981-01-18
US4309437A (en) 1982-01-05
CH648848A5 (de) 1985-04-15
CA1152985A (en) 1983-08-30
JPS5615289A (en) 1981-02-14

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE GREEN CROSS CORP.

Effective date: 19870331