BE880042A - 5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation. - Google Patents
5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation.Info
- Publication number
- BE880042A BE880042A BE0/198116A BE198116A BE880042A BE 880042 A BE880042 A BE 880042A BE 0/198116 A BE0/198116 A BE 0/198116A BE 198116 A BE198116 A BE 198116A BE 880042 A BE880042 A BE 880042A
- Authority
- BE
- Belgium
- Prior art keywords
- aminopyrimidines
- imidazolin
- substituted
- preparation process
- preparation
- Prior art date
Links
- -1 2-IMIDAZOLIN-2-YL Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2849537A DE2849537C2 (de) | 1978-11-15 | 1978-11-15 | Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE880042A true BE880042A (fr) | 1980-05-14 |
Family
ID=6054732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/198116A BE880042A (fr) | 1978-11-15 | 1979-11-14 | 5-(2-imidazolin-2-yl)-aminopyrimidines substituees et leur procede de preparation. |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5592383A (enrdf_load_stackoverflow) |
| BE (1) | BE880042A (enrdf_load_stackoverflow) |
| DE (1) | DE2849537C2 (enrdf_load_stackoverflow) |
| ZA (1) | ZA796148B (enrdf_load_stackoverflow) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016767A1 (de) * | 1980-04-30 | 1981-11-05 | Beiersdorf Ag, 2000 Hamburg | Pyrimidylthioharnstoffe, diese enthaltende arzneimittel und deren verwendung |
| DE3423328A1 (de) * | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
| DE3423293C2 (de) * | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
| DE4423177A1 (de) * | 1994-07-01 | 1996-01-04 | Kali Chemie Pharma Gmbh | Antihyperglykämisch wirksame Arzneimittel |
| DE19911371A1 (de) | 1999-03-15 | 2000-09-21 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen |
| CA2487541A1 (en) | 2002-06-19 | 2003-12-31 | Solvay Pharmaceuticals Gmbh | Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins |
| CN101370500A (zh) * | 2006-01-27 | 2009-02-18 | 弗·哈夫曼-拉罗切有限公司 | 2-咪唑化合物用于治疗cns障碍的用途 |
| ATE407931T1 (de) * | 2006-06-26 | 2008-09-15 | Chemagis Ltd | Verbessertes verfahren zur herstellung von moxonidine |
| BRPI0806940A2 (pt) | 2007-02-02 | 2014-05-06 | Hoffmann La Roche | 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc |
| RU2460725C2 (ru) | 2007-02-15 | 2012-09-10 | Ф. Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 |
| US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| DE102012215896A1 (de) | 2012-09-07 | 2014-03-13 | Wörwag Pharma GmbH & Co.KG | Moxonidinsynthese mit Hilfe organischer Basen |
| ES2608004T3 (es) | 2012-12-03 | 2017-04-05 | WÖRWAG PHARMA GmbH & Co. KG | Método mediante catálisis por transferencia de fase |
| EP2765131B1 (en) | 2013-02-08 | 2016-11-23 | Arevipharma GmbH | Process for the production of Moxonidine |
| EP3430010B1 (en) | 2016-03-17 | 2020-07-15 | H. Hoffnabb-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
| JP2023549394A (ja) * | 2020-11-12 | 2023-11-24 | スリールセータ エーハゥーエッフ | 注意欠陥／多動性障害の新規な治療 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754832A (fr) * | 1969-08-14 | 1971-02-15 | Beecham Group Ltd | Iminazolines |
| BE503170A (enrdf_load_stackoverflow) * | 1975-09-02 |
-
1978
- 1978-11-15 DE DE2849537A patent/DE2849537C2/de not_active Expired
-
1979
- 1979-11-14 BE BE0/198116A patent/BE880042A/fr not_active IP Right Cessation
- 1979-11-15 JP JP14717779A patent/JPS5592383A/ja active Granted
- 1979-11-15 ZA ZA00796148A patent/ZA796148B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2849537A1 (de) | 1980-05-22 |
| JPS6354714B2 (enrdf_load_stackoverflow) | 1988-10-28 |
| JPS5592383A (en) | 1980-07-12 |
| DE2849537C2 (de) | 1983-03-17 |
| ZA796148B (en) | 1980-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CCPA | Application for a supplementary protection certificate |
Free format text: 095C0011 |
|
| CCPV | Grant of a supplementary protection certificate |
Free format text: 095C0011, EXPIRES:20041114 |
|
| RE20 | Patent expired |
Owner name: BEIERSDORF - LILLY G.M.B.H. Effective date: 19991114 |
|
| CCCH | Change of ownership of the supplementary protection certificate |
Owner name: SOLVAY PHARMACEUTICALS G.M.B.H. Spc suppl protection certif: 95C0011 |
|
| CCCH | Change of ownership of the supplementary protection certificate |
Owner name: OLVAY PHARMACEUTICALS G.M.B.H. Spc suppl protection certif: 95C0011 Filing date: 19991114 |
|
| CCRE | Expiry of a supplementary protection certificate |
Free format text: PRODUCT NAME: MOCONIDINE-BASE; NAT. REGISTRATION NO/DATE: 410 IS 191 F3 / 19950418; FIRST REGISTRATION: DE 9953.00.00 19910123 Spc suppl protection certif: 95C0011 Filing date: 19951017 Expiry date: 19991114 Extension date: 20041114 |