BE875469A - Nouveaux composes de type beta-lactame utiles comme agents antimicrobiens et leur procede de preparation - Google Patents

Nouveaux composes de type beta-lactame utiles comme agents antimicrobiens et leur procede de preparation

Info

Publication number
BE875469A
BE875469A BE0/194518A BE194518A BE875469A BE 875469 A BE875469 A BE 875469A BE 0/194518 A BE0/194518 A BE 0/194518A BE 194518 A BE194518 A BE 194518A BE 875469 A BE875469 A BE 875469A
Authority
BE
Belgium
Prior art keywords
emi
formula
compound
mixture
reaction
Prior art date
Application number
BE0/194518A
Other languages
English (en)
French (fr)
Inventor
Hiroshi Ishikawa
Fujio Tabusa
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BE875469A publication Critical patent/BE875469A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE0/194518A 1978-04-12 1979-04-10 Nouveaux composes de type beta-lactame utiles comme agents antimicrobiens et leur procede de preparation BE875469A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53043624A JPS6034957B2 (ja) 1978-04-12 1978-04-12 ペニシラン酸誘導体

Publications (1)

Publication Number Publication Date
BE875469A true BE875469A (fr) 1979-10-10

Family

ID=12668994

Family Applications (2)

Application Number Title Priority Date Filing Date
BE0/194519A BE875470A (fr) 1978-04-12 1979-04-10 Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques
BE0/194518A BE875469A (fr) 1978-04-12 1979-04-10 Nouveaux composes de type beta-lactame utiles comme agents antimicrobiens et leur procede de preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE0/194519A BE875470A (fr) 1978-04-12 1979-04-10 Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques

Country Status (3)

Country Link
JP (1) JPS6034957B2 (xx)
BE (2) BE875470A (xx)
ZA (1) ZA791713B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2467205A1 (fr) * 1979-10-11 1981-04-17 Otsuka Pharma Co Ltd Derives d'acide benzo(ij)quinolizine carboxylique-2, utiles notamment comme medicaments antimicrobiens, procede de leur preparation et compositions therapeutiques et formes pharmaceutiques les contenant

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6118566A (ja) * 1984-07-05 1986-01-27 Toyoda Mach Works Ltd 動力舵取装置の操舵力制御装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2467205A1 (fr) * 1979-10-11 1981-04-17 Otsuka Pharma Co Ltd Derives d'acide benzo(ij)quinolizine carboxylique-2, utiles notamment comme medicaments antimicrobiens, procede de leur preparation et compositions therapeutiques et formes pharmaceutiques les contenant
DE3037103A1 (de) * 1979-10-11 1981-05-07 Otsuka Pharmaceutical Co. Ltd., Tokyo Benzo (ij) zu chinolizin-2-carbonsaeuren und diese v erbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
BE875470A (fr) 1979-10-10
ZA791713B (en) 1980-04-30
JPS54135767A (en) 1979-10-22
JPS6034957B2 (ja) 1985-08-12

Similar Documents

Publication Publication Date Title
BE1006343A5 (fr) Derives de l'indole.
FR2493849A1 (fr) Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
EP0691339A1 (fr) Dérivés amines de 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones et oxazolo(4,5-b)pyridin-2(3H)-ones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0134165B1 (fr) Dérivés 7-(pyrrol-1-yl) des acides 1-éthyl-1,4-dihydro-4-oxoquinoléine-3-carboxyliques et 1-éthyl-1,4-dihydro-4-oxo-(1,8-naphtyridine)-3-carboxyliques substitués, leur préparation et leur application en tant que médicaments
DE2953974C2 (xx)
FR2500833A1 (fr) Nouveaux derives de l'acide (pyrrolidinyl-1)-7 fluoro-6 dihydro-1,4 oxo-4 naphtyridine-1, 8 carboxylique-3 et leur utilisation comme medicament
CH630085A5 (fr) Nouvelles imidazoquinoleines et leurs sels, procede de preparation et compositions pharmaceutiques.
FR2467205A1 (fr) Derives d'acide benzo(ij)quinolizine carboxylique-2, utiles notamment comme medicaments antimicrobiens, procede de leur preparation et compositions therapeutiques et formes pharmaceutiques les contenant
BE891046A (fr) Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
CH630629A5 (fr) Derives de la morphine, leur procede de preparation et leur application comme medicament.
HU185329B (en) Process for preparing quinolone derivatives and pharmaceutical compositions containing such compounds
BE875469A (fr) Nouveaux composes de type beta-lactame utiles comme agents antimicrobiens et leur procede de preparation
WO2000077003A1 (fr) Composes de pyrrolopyridazine optiquement actifs
EP0233800B1 (fr) Dérivés d'imidazo[1,2-a]quinoléines, leur préparation et leur application en thérapeutique
FR2496663A1 (fr) Nouveaux derives de naphtyridine-1,8 utiles notamment comme medicaments antibacteriens
FR2508457A1 (fr) Pyrrolo(2,1-b)quinazolines et pyrido(2,1-b)quinazolines substituees, leur preparation et leurs utilisations therapeutiques
EP0402232A1 (fr) Dérivés de pyridobenzoindole, leur préparation et les compositions qui les contiennent
EP0008610B1 (en) Furonaphthyridine compounds, process for their preparation and pharmaceutical compositions containing them
US4317820A (en) β-Lactam series compound and antibacterial pharmaceutical composition containing the same
EP0231138B1 (fr) Dérivés d'acylaminométhyl-1imidazo [1,2-a] quinoléines, leur préparation et leur application en thérapeutique
US4497816A (en) 7-(4-Pyridyl)-1,8-naphthyridine derivatives and their antibacterial compositions
BE821481R (fr) Nouveaux derives de piperazine et procede pour leur no 121.058/73
JP2666320B2 (ja) 抗菌化合物
BE884145R (fr) Composes indoliques nouveaux
CH638210A5 (fr) Ester derive de l'acide quinolopyranne-4-one-2-carboxylique, procede de sa preparation et utilisation de cet ester comme compose actif dans un medicament antiallergique pour le traitement de l'asthme.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: OTSUKA PHARMACEUTICAL CO. LTD

Effective date: 19910430