BE855795A - Procede de synthese d'anthracyclinones optiquement actives - Google Patents

Procede de synthese d'anthracyclinones optiquement actives

Info

Publication number
BE855795A
BE855795A BE178520A BE178520A BE855795A BE 855795 A BE855795 A BE 855795A BE 178520 A BE178520 A BE 178520A BE 178520 A BE178520 A BE 178520A BE 855795 A BE855795 A BE 855795A
Authority
BE
Belgium
Prior art keywords
optically active
synthesis process
anthracyclinones
active anthracyclinones
synthesis
Prior art date
Application number
BE178520A
Other languages
English (en)
Inventor
Luigi Bernardi
Pietro Giardino
Bianca Patelli
Federico Arcamone
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of BE855795A publication Critical patent/BE855795A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
BE178520A 1976-06-19 1977-06-17 Procede de synthese d'anthracyclinones optiquement actives BE855795A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB25517/76A GB1527050A (en) 1976-06-19 1976-06-19 Optically active anthracyclinones

Publications (1)

Publication Number Publication Date
BE855795A true BE855795A (fr) 1977-12-19

Family

ID=10228981

Family Applications (1)

Application Number Title Priority Date Filing Date
BE178520A BE855795A (fr) 1976-06-19 1977-06-17 Procede de synthese d'anthracyclinones optiquement actives

Country Status (14)

Country Link
US (1) US4132721A (fr)
JP (1) JPS6058213B2 (fr)
AT (1) AT347445B (fr)
AU (1) AU511513B2 (fr)
BE (1) BE855795A (fr)
CA (1) CA1076561A (fr)
CH (1) CH629743A5 (fr)
DE (1) DE2727341C3 (fr)
DK (1) DK152357C (fr)
FR (1) FR2354990A1 (fr)
GB (1) GB1527050A (fr)
NL (1) NL175616C (fr)
SE (1) SE440500B (fr)
ZA (1) ZA773644B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215062A (en) * 1978-05-22 1980-07-29 University Of Kansas Endowment Association Anthracycline synthesis
JPS54160356A (en) * 1978-06-05 1979-12-19 Univ Kansas State Synthesis of tetrahydronaphthalene
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
DE10155016A1 (de) * 2001-11-07 2003-05-15 Knoell Hans Forschung Ev Neue Chinon-Verbindung, Verfahren zur Herstellung und deren Verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201424A (en) * 1962-10-29 1965-08-17 American Cyanamid Co Derivatives of 1, 3, 11, 12-tetrahydroxynaphthacene and 1, 3, 6, 11-tetrahydroxynaphtacene-5, 12-quinone
GB1461190A (en) * 1974-09-20 1977-01-13 Farmaceutici Italia Anthracycline preparation
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4070382A (en) * 1975-11-18 1978-01-24 Research Corporation Intermediates for polycyclic quinoid antibiotics
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin

Also Published As

Publication number Publication date
NL175616C (nl) 1984-12-03
AU511513B2 (en) 1980-08-21
AT347445B (de) 1978-12-27
CH629743A5 (de) 1982-05-14
ATA427577A (de) 1978-05-15
AU2609877A (en) 1978-12-21
DE2727341C3 (de) 1982-05-06
ZA773644B (en) 1978-05-30
NL7706471A (nl) 1977-12-21
DK265977A (da) 1977-12-20
US4132721A (en) 1979-01-02
NL175616B (nl) 1984-07-02
CA1076561A (fr) 1980-04-29
FR2354990A1 (fr) 1978-01-13
JPS52156852A (en) 1977-12-27
SE7707037L (sv) 1977-12-19
SE440500B (sv) 1985-08-05
GB1527050A (en) 1978-10-04
DE2727341B2 (de) 1981-10-08
FR2354990B1 (fr) 1983-07-29
DE2727341A1 (de) 1977-12-22
DK152357B (da) 1988-02-22
DK152357C (da) 1988-09-12
JPS6058213B2 (ja) 1985-12-19

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SOCIETA FARMACEUTICI ITALIA S.P.A.

Effective date: 19970617