BE854097Q - INDUSTRIAL PREPARATION PROCESS OF SORTING (HYDROXYMATHYL) AMINO-METHANE-GLUCONATE-DI-HYDROXY-ALUMINATE - Google Patents
INDUSTRIAL PREPARATION PROCESS OF SORTING (HYDROXYMATHYL) AMINO-METHANE-GLUCONATE-DI-HYDROXY-ALUMINATEInfo
- Publication number
- BE854097Q BE854097Q BE177122A BE177122A BE854097Q BE 854097 Q BE854097 Q BE 854097Q BE 177122 A BE177122 A BE 177122A BE 177122 A BE177122 A BE 177122A BE 854097 Q BE854097 Q BE 854097Q
- Authority
- BE
- Belgium
- Prior art keywords
- emi
- aluminate
- gluconate
- hydroxymathyl
- methane
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 4
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 3
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 235000012208 gluconic acid Nutrition 0.000 claims description 3
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 3
- 229960003681 gluconolactone Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000010907 mechanical stirring Methods 0.000 claims description 2
- 239000000174 gluconic acid Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 3
- 229950006191 gluconic acid Drugs 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 150000004645 aluminates Chemical class 0.000 description 1
- ICPMTQOYWXXMIG-OPDGVEILSA-K aluminum;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Al+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O ICPMTQOYWXXMIG-OPDGVEILSA-K 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
- C07F5/069—Aluminium compounds without C-aluminium linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/10—Polyhydroxy carboxylic acids
- C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<EMI ID=1.1>
<EMI ID=2.1>
<EMI ID=3.1>
<EMI ID=4.1>
<EMI ID=5.1>
Le composé obtenu par le procédé suivant la présenta invention est déjà connu (voir Journal of Pharmaceutical Sciences-
<EMI ID=6.1>
acide idéal, et donc sa haute capacité neutralisante par unité en poids ont déjà été étudiées. Toutefois, les pro-
<EMI ID=7.1>
utilisables qu'au laboratoire et ne sont pas transposables
à l'échelle industrielle par suite de nombreuses difficultés qui se présentent pour l'homme de l'art.
Pour remédier à ces inconvénients, la présente invention propose un procédé de fabrication industriel-
<EMI ID=8.1>
aluminate suivant le shhéma de réaction suivant :
<EMI ID=9.1>
<EMI ID=10.1>
de gluconolactone, on obtient après dissolution dans l'eau et hydrolyse une solution d'acide D-gluconique, que l'on
<EMI ID=11.1>
prise par la lecture de l'exemple ci-après donné simplement à titre indicatif et donc non pas limitatif :
Exemple.
Dans un matras de 2 1, on a dissout 375 g
de gluconolactone dans 720 ml d'eau sous agitation Mécanique,
<EMI ID=12.1> <EMI ID=13.1>
<EMI ID=14.1>
mélange, sous agitation à 65[deg.]C, jusqu'à dissolution complète (environ 3 heures), puis on l'a fait refroidir et précipiter avec environ 1 200 ml d'acétone, on a filtré, puis lavé deux fois avec 200 ml d'acétone. On a ensuite
<EMI ID=15.1>
On a obtenu 440 g de gluconate d'aluminium à 94,5 % avec un rendement de 88 %.
<EMI ID=16.1>
<EMI ID=17.1>
dans 50 ml d'eau ; on a ajouté sous agitation 8,93 g
<EMI ID=18.1>
dissous dans 15 ml d'eau, on a poursuivi l'agitation à froid pendant 30 minutes (dissolution complète) et ensuite on a évaporé selon le "spray-drying".
<EMI ID=19.1>
Le pouvoir tampon du produit obtenu suivant
<EMI ID=20.1>
produit parfaitement anhydre.
<EMI ID=21.1>
à l'exemple de réalisation ci-dessus décrit, à partir duquel on pourra prévoir d'autres formes et d'autres -modes de réalisation, sans pour cela sortir du cadre de l'inven-
<EMI ID=22.1>
<EMI ID=23.1>
caractérisé en ce que, dans une première phase, on fait réagir de l'acide D-gluconique avec de l'isopropylate d'aluminium et, dans une seconde phase, on fait réagir
<EMI ID=24.1>
<EMI ID = 1.1>
<EMI ID = 2.1>
<EMI ID = 3.1>
<EMI ID = 4.1>
<EMI ID = 5.1>
The compound obtained by the process according to the present invention is already known (see Journal of Pharmaceutical Sciences-
<EMI ID = 6.1>
ideal acid, and therefore its high neutralizing capacity per unit by weight have already been studied. However, the pro-
<EMI ID = 7.1>
can only be used in the laboratory and cannot be transposed
on an industrial scale as a result of numerous difficulties which arise for those skilled in the art.
To remedy these drawbacks, the present invention provides an industrial manufacturing process.
<EMI ID = 8.1>
aluminate according to the following reaction diagram:
<EMI ID = 9.1>
<EMI ID = 10.1>
gluconolactone, after dissolving in water and hydrolyzing a solution of D-gluconic acid, which is obtained
<EMI ID = 11.1>
taken by reading the example below given simply as an indication and therefore not limiting:
Example.
In a matras of 2 1, we dissolved 375 g
of gluconolactone in 720 ml of water with mechanical stirring,
<EMI ID = 12.1> <EMI ID = 13.1>
<EMI ID = 14.1>
mixture, with stirring at 65 [deg.] C, until complete dissolution (about 3 hours), then cooled and precipitated with about 1200 ml of acetone, filtered, then washed twice with 200 ml of acetone. We then have
<EMI ID = 15.1>
440 g of 94.5% aluminum gluconate were obtained with a yield of 88%.
<EMI ID = 16.1>
<EMI ID = 17.1>
in 50 ml of water; 8.93 g were added with stirring
<EMI ID = 18.1>
dissolved in 15 ml of water, stirring was continued in the cold for 30 minutes (complete dissolution) and then evaporated according to "spray-drying".
<EMI ID = 19.1>
The buffering capacity of the following product
<EMI ID = 20.1>
perfectly anhydrous product.
<EMI ID = 21.1>
to the embodiment described above, from which other shapes and other embodiments can be provided, without departing from the scope of the invention
<EMI ID = 22.1>
<EMI ID = 23.1>
characterized in that, in a first phase, D-gluconic acid is reacted with aluminum isopropylate and, in a second phase, it is reacted
<EMI ID = 24.1>
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| VE3435075 | 1975-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE854097Q true BE854097Q (en) | 1977-08-16 |
Family
ID=25546971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE177122A BE854097Q (en) | 1975-05-19 | 1977-04-29 | INDUSTRIAL PREPARATION PROCESS OF SORTING (HYDROXYMATHYL) AMINO-METHANE-GLUCONATE-DI-HYDROXY-ALUMINATE |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE854097Q (en) |
-
1977
- 1977-04-29 BE BE177122A patent/BE854097Q/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: SCHARPER S.P.A. PER L'INDUSTRIA FARMACEUTICA Effective date: 19870430 |