BE801587A - Arginine and lysine salts of cephalosphorin - from cephalosporanic acid with arginine or lysine, have reduced side effects - Google Patents

Arginine and lysine salts of cephalosphorin - from cephalosporanic acid with arginine or lysine, have reduced side effects

Info

Publication number
BE801587A
BE801587A BE132835A BE132835A BE801587A BE 801587 A BE801587 A BE 801587A BE 132835 A BE132835 A BE 132835A BE 132835 A BE132835 A BE 132835A BE 801587 A BE801587 A BE 801587A
Authority
BE
Belgium
Prior art keywords
arginine
lysine
salts
cephalosporanic acid
cephalosphorin
Prior art date
Application number
BE132835A
Other languages
French (fr)
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of BE801587A publication Critical patent/BE801587A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Salts of cephaloporanic acids of formula (I): (where R1 = phenyl, 2-thienyl, phenoxy, 1-cyclohexenyl, tetrazolyl, CN, 4-pyridylthio, phenylthio, (1'imino-2'-phenylethyl)amino or 2-(3-sydnone); R2 = H, sulpho, carboxyl, NH2, CH3, or C2H51 R3 = CH3, acetoxymethyl, pyridylmethyl, (4-carbamoyl) pyridyl-methyl, 6-(3-methylpyrid zinyl -2-oxido)thiomethyl or 5-(2-methylthiadiazolyl)thiomethyl; X = H, acetoxy, alkoxy, substd. thio or tert. ammonium), with arginine or lysine, are prepd. by reacting a cephalosporanic acid (I) with arginine or lysine. Upon injection, the salts do not show side-effects, e.g. pain, swelling, hardening etc. They are more stable and more water-soluble than (I) while retaning the same antibacterial activity.
BE132835A 1972-06-30 1973-06-28 Arginine and lysine salts of cephalosphorin - from cephalosporanic acid with arginine or lysine, have reduced side effects BE801587A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP47066076A JPS4925118A (en) 1972-06-30 1972-06-30

Publications (1)

Publication Number Publication Date
BE801587A true BE801587A (en) 1973-12-28

Family

ID=13305378

Family Applications (1)

Application Number Title Priority Date Filing Date
BE132835A BE801587A (en) 1972-06-30 1973-06-28 Arginine and lysine salts of cephalosphorin - from cephalosporanic acid with arginine or lysine, have reduced side effects

Country Status (3)

Country Link
JP (1) JPS4925118A (en)
BE (1) BE801587A (en)
SE (1) SE402917B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600635B1 (en) * 1986-06-26 1989-09-08 Comalco Alu PROCESS FOR THE PRODUCTION OF USEFUL MATERIALS INCLUDING SYNTHETIC NEPHELIN FROM RED MUD OF THE BAYER PROCESS
AU2017267768A1 (en) * 2016-05-16 2019-01-03 Gb001, Inc. Crystal of quinoline derivative

Also Published As

Publication number Publication date
JPS4925118A (en) 1974-03-06
SE402917B (en) 1978-07-24

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: TAKEDA CHEMICAL INDUSTRIES LTD

Effective date: 19930628