IE39373L - 3-(substituted-ethyl)-cephalosporin derivatives - Google Patents
3-(substituted-ethyl)-cephalosporin derivativesInfo
- Publication number
- IE39373L IE39373L IE84174A IE84174A IE39373L IE 39373 L IE39373 L IE 39373L IE 84174 A IE84174 A IE 84174A IE 84174 A IE84174 A IE 84174A IE 39373 L IE39373 L IE 39373L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- denotes
- thiourea
- substituted
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cephem compounds of the accompanying formula I are prepared. In this formula R<1> denotes a free or protected amino group, preferably an acylamido group; and Y denotes the radical of a thiourea bonded via sulphur, which thiourea can be substituted, or denotes thioamide, thiol or thiophenol. The compounds can additionally carry further substituents in the 2- or 7-position. These compounds are distinguished by an antibiotic activity and can be employed in human and veterinary medicine. Of these compounds, those in which R<1> denotes an acylamido group and Y corresponds to a pyrid-2-ylthio radical are preferred on account of their activity against a multiplicity of Gram-positive and Gram-negative organisms. The compounds of the formula I are prepared by reaction of the corresponding 3-vinyl compound with a thiourea, substituted thiourea, thioamide, thiol or thiophenol. <IMAGE>
[GB1463077A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1908073A GB1463077A (en) | 1973-04-19 | 1973-04-19 | 7-substituted-ethyl-cephalosporin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39373L true IE39373L (en) | 1974-10-19 |
| IE39373B1 IE39373B1 (en) | 1978-09-27 |
Family
ID=10123445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE84174A IE39373B1 (en) | 1973-04-19 | 1974-04-18 | 3-substituted ethyl-cephalosporin compounds |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5030900A (en) |
| BE (1) | BE813892A (en) |
| CH (1) | CH615186A5 (en) |
| DE (1) | DE2418768A1 (en) |
| FR (1) | FR2226406B1 (en) |
| GB (1) | GB1463077A (en) |
| IE (1) | IE39373B1 (en) |
| LU (1) | LU69884A1 (en) |
| NL (1) | NL7405257A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4954253U (en) * | 1972-08-22 | 1974-05-14 | ||
| FR2457296A1 (en) * | 1979-05-23 | 1980-12-19 | Rhone Poulenc Ind | NOVEL VINYL-3 CEPHALOSPORINS DERIVATIVES AND THEIR PREPARATION |
| PT71654B (en) * | 1979-08-15 | 1982-01-22 | Merck & Co Inc | Process for preparing allylsulfoxide enzyme inhibitor |
| US4342758A (en) | 1979-08-15 | 1982-08-03 | Merck & Co., Inc. | Allylsulfoxide enzyme inhibitors |
-
1973
- 1973-04-19 GB GB1908073A patent/GB1463077A/en not_active Expired
-
1974
- 1974-04-18 NL NL7405257A patent/NL7405257A/xx unknown
- 1974-04-18 IE IE84174A patent/IE39373B1/en unknown
- 1974-04-18 LU LU69884A patent/LU69884A1/xx unknown
- 1974-04-18 CH CH539074A patent/CH615186A5/en not_active IP Right Cessation
- 1974-04-18 JP JP4385274A patent/JPS5030900A/ja active Pending
- 1974-04-18 BE BE143354A patent/BE813892A/en not_active IP Right Cessation
- 1974-04-18 DE DE19742418768 patent/DE2418768A1/en not_active Withdrawn
- 1974-04-19 FR FR7413830A patent/FR2226406B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2226406A1 (en) | 1974-11-15 |
| CH615186A5 (en) | 1980-01-15 |
| JPS5030900A (en) | 1975-03-27 |
| LU69884A1 (en) | 1974-07-18 |
| FR2226406B1 (en) | 1978-08-11 |
| DE2418768A1 (en) | 1974-10-31 |
| BE813892A (en) | 1974-10-18 |
| NL7405257A (en) | 1974-10-22 |
| IE39373B1 (en) | 1978-09-27 |
| GB1463077A (en) | 1977-02-02 |
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