FR2187349A1 - Dihydropyridine carboxamides - antihypertensives - Google Patents

Dihydropyridine carboxamides - antihypertensives

Info

Publication number
FR2187349A1
FR2187349A1 FR7321038A FR7321038A FR2187349A1 FR 2187349 A1 FR2187349 A1 FR 2187349A1 FR 7321038 A FR7321038 A FR 7321038A FR 7321038 A FR7321038 A FR 7321038A FR 2187349 A1 FR2187349 A1 FR 2187349A1
Authority
FR
France
Prior art keywords
opt
alkyl
alkoxy
branched
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7321038A
Other languages
French (fr)
Other versions
FR2187349B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2187349A1 publication Critical patent/FR2187349A1/en
Application granted granted Critical
Publication of FR2187349B1 publication Critical patent/FR2187349B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Title cpds. are of formula (I): (where R = H or opt. branched and/or unsatd. hydrocarbyl; R1 and R4 = H or alkyl; R2 and R3 = NR6R7, R6, R7 = H, alkyl or complete a heterocycle opt. contg. additional O, S, NH or Nalkyl; R3 = opt. branched and/or unsatd. hydrocarbyl, alkoxy, alkenoxy, the last 2 opt. branched or cyclic and opt. substd. by 1 or 2 OH and interrupted by 1 or 2 O; R5 = phenyl substd. by up to 3 NO2, CN, N2, alkyl, alkoxy, acetoxy, carbalkoxy, NH2, acetylamino, mono- or di-alkylamino, alkyl(SO)n, n = 0-2, CF3 and/or halo; or is benzyl, styryl, cycloalk(en)yl, or is naphthyl, (iso)quinolyl, pyridyl, pyrimidinyl, thenyl, furyl or pyrryl, opt. substd. by alkyl, alkoxy, nitro or halo) and are prepd. e.g., by reacting R1CO.CH2COR2 with H2NR to give R1C(NHR)=CH.COR2 which is then reacted with R5CH=C(COR3).COR4.
FR7321038A 1972-06-10 1973-06-08 Dihydropyridine carboxamides - antihypertensives Granted FR2187349A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722228377 DE2228377A1 (en) 1972-06-10 1972-06-10 DIHYDROPYRIDINE CARBONIC ACID AMIDES, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT

Publications (2)

Publication Number Publication Date
FR2187349A1 true FR2187349A1 (en) 1974-01-18
FR2187349B1 FR2187349B1 (en) 1977-09-09

Family

ID=5847409

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7321038A Granted FR2187349A1 (en) 1972-06-10 1973-06-08 Dihydropyridine carboxamides - antihypertensives

Country Status (3)

Country Link
BE (1) BE800680A (en)
DE (1) DE2228377A1 (en)
FR (1) FR2187349A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083315A2 (en) * 1981-12-30 1983-07-06 Ciba-Geigy Ag Pyridyl-N-oxides, processes for their preparation and pharmaceutical compositions containing them
EP0111453A1 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Amide derivatives
FR2545826A1 (en) * 1982-03-22 1984-11-16 Bristol Myers Co CYCLIC DIHYDROPYRIDYLIMIDATES, AND THEIR PHARMACOLOGICAL APPLICATION
EP0174131A2 (en) * 1984-09-01 1986-03-12 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
EP0288758A2 (en) * 1987-04-09 1988-11-02 Bayer Ag Dihydropyridinamides, process for their preparation and their use in medicines

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3319956A1 (en) * 1983-06-01 1984-12-06 Bayer Ag, 5090 Leverkusen 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
JPS62174050A (en) * 1985-10-21 1987-07-30 Nippon Shoji Kk 3-aminocarbonyl-1, 4-dihydropyridine-5-carboxylic acid derivative, production thereof and drug composition
DE3601397A1 (en) * 1986-01-18 1987-07-23 Bayer Ag SUBSTITUTED 1,4-DIHYDROPYRIDIN-3-CARBONIC ACID PIPERAZIDES, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
GB8620880D0 (en) * 1986-08-29 1986-10-08 Pfizer Ltd Therapeutic agents
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
DE3833892A1 (en) * 1988-10-05 1990-04-12 Bayer Ag BASIC 4-ARYL-DHP AMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
DE4011695A1 (en) * 1990-04-11 1991-10-17 Bayer Ag USE OF N-ALKYLATED 1,4-DIHYDROPYRIDE INDICARBOXIC ACID ESTERS AS DRUGS, NEW COMPOUNDS AND METHOD FOR THEIR PREPARATION
DE4100125A1 (en) * 1991-01-04 1992-07-09 Bayer Ag NEW DIHYDROPYRIDINAMID, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
EP2311806A3 (en) * 1996-01-29 2011-08-10 The United States of America, Represented by the Secretary, Department of Health and Human Services Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists
US6316423B1 (en) 1996-04-10 2001-11-13 The United States Of America As Represented By The Departmant Of Health And Human Services Method of treating ischemic, hypoxic and anoxic brain damage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
1970 , 35.319V CITE YAKUGAKU ZASSHI 1970 , 90 5 , 606-612 JAPAN .) *
CHEMICAL ABSTRACTS, VOL. 73 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083315A2 (en) * 1981-12-30 1983-07-06 Ciba-Geigy Ag Pyridyl-N-oxides, processes for their preparation and pharmaceutical compositions containing them
EP0083315A3 (en) * 1981-12-30 1983-08-24 Ciba-Geigy Ag Pyridyl-n-oxides, processes for their preparation and pharmaceutical compositions containing them
FR2545826A1 (en) * 1982-03-22 1984-11-16 Bristol Myers Co CYCLIC DIHYDROPYRIDYLIMIDATES, AND THEIR PHARMACOLOGICAL APPLICATION
EP0111453A1 (en) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Amide derivatives
EP0174131A2 (en) * 1984-09-01 1986-03-12 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
EP0288758A2 (en) * 1987-04-09 1988-11-02 Bayer Ag Dihydropyridinamides, process for their preparation and their use in medicines
EP0288758A3 (en) * 1987-04-09 1989-03-01 Bayer Ag Dihydropyridinamides, process for their preparation and their use in medicines

Also Published As

Publication number Publication date
FR2187349B1 (en) 1977-09-09
BE800680A (en) 1973-12-10
DE2228377A1 (en) 1974-01-03

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Legal Events

Date Code Title Description
ST Notification of lapse