BE799611A - Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation - Google Patents

Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation

Info

Publication number
BE799611A
BE799611A BE131180A BE131180A BE799611A BE 799611 A BE799611 A BE 799611A BE 131180 A BE131180 A BE 131180A BE 131180 A BE131180 A BE 131180A BE 799611 A BE799611 A BE 799611A
Authority
BE
Belgium
Prior art keywords
new
preparation process
amino benzoyl
phenylacetic acids
phenylacetic
Prior art date
Application number
BE131180A
Other languages
English (en)
Inventor
W J Welstead
H W Moran
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of BE799611A publication Critical patent/BE799611A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
BE131180A 1975-08-13 1973-05-16 Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation BE799611A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/604,371 US4045576A (en) 1975-08-13 1975-08-13 Anti-inflammatory methods using 2-amino-3-(5- and 6-)benzoylphenylacetic acids, esters and metal salts thereof and the compounds

Publications (1)

Publication Number Publication Date
BE799611A true BE799611A (fr) 1973-09-17

Family

ID=24419335

Family Applications (2)

Application Number Title Priority Date Filing Date
BE131180A BE799611A (fr) 1975-08-13 1973-05-16 Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation
BE163180A BE837154A (fr) 1975-08-13 1975-12-29 Acides 2-amino-3-(5- et 6-)- benzoyl - phenylacetiques, leurs esters et leurs sels metalliques

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE163180A BE837154A (fr) 1975-08-13 1975-12-29 Acides 2-amino-3-(5- et 6-)- benzoyl - phenylacetiques, leurs esters et leurs sels metalliques

Country Status (15)

Country Link
US (3) US4045576A (fr)
JP (3) JPS523381B2 (fr)
AT (2) AT329542B (fr)
AU (1) AU530940B2 (fr)
BE (2) BE799611A (fr)
CA (2) CA1012979A (fr)
CH (1) CH577461A5 (fr)
DE (2) DE2324768C2 (fr)
ES (1) ES446625A1 (fr)
FR (1) FR2184934B1 (fr)
GB (2) GB1432576A (fr)
MX (1) MX4035E (fr)
NL (1) NL183722C (fr)
PH (2) PH12656A (fr)
SE (1) SE400966B (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror
FR2366015A1 (fr) * 1975-11-05 1978-04-28 Robins Co Inc A H Nouveaux acides amino-2 benzoyl-3 (5 et 6) phenylacetiques et leurs esters et sels de metaux alcalins, utiles notamment comme anti-inflammatoires, et leur procede de preparation
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones
EP0089426B1 (fr) * 1979-07-12 1986-06-11 A.H. Robins Company, Incorporated Acides 2-amino-6-biphénylacétiques
IL60444A (en) * 1979-08-01 1985-03-31 Robins Co Inc A H 2-amino-3-(alkylthiobenzoyl)-phenylacetic acid derivatives and pharmaceutical compositions containing them
US4313949A (en) * 1979-09-26 1982-02-02 A. H. Robins Company, Inc. Method of producing an inhibitory effect on blood platelet aggregation
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
US4254146A (en) * 1979-10-18 1981-03-03 A. H. Robins Company, Inc. 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US4503073A (en) * 1981-01-07 1985-03-05 A. H. Robins Company, Incorporated 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
JPS6019753A (ja) * 1983-07-13 1985-01-31 Shionogi & Co Ltd オルト−（モノ置換アミノ）フエニルイミン類およびその製造法
JPS6026586U (ja) * 1983-07-29 1985-02-22 日本軽金属株式会社 改装サッシ窓における隙間閉塞装置
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US4782089A (en) * 1986-08-26 1988-11-01 A. H. Robins Company, Incorporated 2-amino-3-aroyl-gamma-oxobenzenebutanoic acids and esters
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
US4910225A (en) * 1988-01-27 1990-03-20 Senju Pharmaceutical Co., Ltd. Locally administrable therapeutic composition for inflammatory disease
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
AU659106B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
CA2288125A1 (fr) * 1997-04-28 1998-11-05 Medical Information Services, Inc. Procede servant a preparer ketoprofene et 5-benzoyle-3-methyle-2-indolinone
AR030346A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
US7186745B2 (en) * 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
US6646003B2 (en) 2001-04-02 2003-11-11 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
US6692772B2 (en) 2001-07-18 2004-02-17 Cedars-Sinai Medical Center Prevention of in-stent thrombosis and complications after arterial angioplasty with stent placement using magnesium
JP2005525408A (ja) * 2002-05-03 2005-08-25 アルコン，インコーポレイテッド アンフェナクまたはネパフェナクを用いる血管内皮増殖因子媒介性血管障害の処置方法
CN100341498C (zh) 2003-01-21 2007-10-10 千寿制药株式会社 含有2－氨基－3－(4－溴苯甲酰基)苯乙酸的水成液制剂
US20030187072A1 (en) * 2003-02-14 2003-10-02 Kapin Michael A. Method of treating angiogenesis-related disorders
TWI358290B (en) * 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
TW200812575A (en) * 2006-04-28 2008-03-16 Alcon Inc Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye
WO2008046049A1 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Dérivés de spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one et composés connexes utilisables pour traiter des maladies dont la médiation est assurée par les canaux sodiques, comme la douleur
WO2008060789A2 (fr) * 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Utilisation de composés de spiro-oxindole comme agents thérapeutiques
WO2008046083A2 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Utilisation de composés oxindole comme agents thérapeutiques
MX2009003874A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos.
WO2008080110A1 (fr) * 2006-12-21 2008-07-03 Alcon, Inc. Méthodes de traitement d'un oedème maculaire et d'une angiogenèse oculaire pathologique à l'aide d'un agent neuroprotecteur et d'un inhibiteur de tyrosine kinases réceptrices
US20090105245A1 (en) * 2006-12-21 2009-04-23 Bingaman David P Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor
US20080153818A1 (en) * 2006-12-21 2008-06-26 Bingaman David P Methods for preventing inflammation during surgery
US20090076150A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched bromfenac
BRPI0908502A2 (pt) * 2008-02-21 2017-05-23 Ista Pharmaceuticals aines oftálmicos como adjuvantes
SG10201703086VA (en) 2008-10-17 2017-05-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their use as therapeutic agents
EP2350091B1 (fr) * 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Composés spiro-oxindole et leur utilisation comme agents thérapeutiques
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
RU2544852C2 (ru) * 2009-10-14 2015-03-20 Ксенон Фармасьютикалз Инк. Способы синтеза спиро-оксиндольных соединений
WO2011047173A2 (fr) * 2009-10-14 2011-04-21 Xenon Pharmaceuticals Inc. Compositions pharmaceutiques à usage oral
GB2484843A (en) * 2009-10-15 2012-04-25 Johnson Matthey Plc Polymorphs of Bromfenac sodium
US8299295B2 (en) 2009-10-15 2012-10-30 Johnson Matthey Public Limited Company Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
GB0919757D0 (en) * 2009-11-12 2009-12-30 Johnson Matthey Plc Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
US9504671B2 (en) 2010-02-26 2016-11-29 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
EP2377850A1 (fr) * 2010-03-30 2011-10-19 Pharmeste S.r.l. Antagonistes de récepteur vanilloïde TRPV1 avec portion bicyclique
CN103380126B (zh) * 2010-12-21 2016-01-20 拜耳知识产权有限责任公司 2-(三嗪基羰基)磺酰苯胺的制备方法
MX358604B (es) 2012-11-19 2018-08-28 Bausch & Lomb Composicion liquida acuosa que contiene acido 2-amino-3-(4-bromobenzoil) fenilacetico.
JP2016522257A (ja) 2013-06-19 2016-07-28 センティス リサーチ センター 安定なブロムフェナク溶液
US20170000889A1 (en) 2013-12-12 2017-01-05 Sentiss Pharma Private Limited Stable bromfenac ophthalmic solution
CN104974057B (zh) * 2014-04-08 2018-05-18 天津金耀集团有限公司 一种溴芬酸钠的制备方法和重要中间体
CN104151182B (zh) * 2014-06-16 2016-03-30 广东众生药业股份有限公司 一种溴芬酸钠倍半水合物的制备方法
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
CN104693019B (zh) * 2015-02-06 2017-02-01 宁波九胜创新医药科技有限公司 一种2,5‑二溴苯乙酸的制备方法
CN106278917B (zh) * 2016-08-12 2018-05-08 合肥久诺医药科技有限公司 一种溴芬酸钠降解杂质标准品的合成方法
CN106278918B (zh) * 2016-08-12 2018-05-11 合肥久诺医药科技有限公司 一种溴芬酸钠杂质标准品2-氨基-3-(4-溴苯甲酰基)苯甲酸的合成方法
JP7015834B2 (ja) 2017-06-30 2022-02-15 株式会社クラレ 変性ポリビニルアルコール樹脂の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (fr) * 1967-07-31 1971-03-24
US3899529A (en) * 1973-02-22 1975-08-12 Merck & Co Inc Aroyl substituted naphthalene acetic acids
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror

Also Published As

Publication number Publication date
ES446625A1 (es) 1977-06-01
AU530940B2 (en) 1983-08-04
JPS4941349A (fr) 1974-04-18
DE2636582C2 (de) 1986-03-27
AT347433B (de) 1978-12-27
NL183722B (nl) 1988-08-01
PH12656A (en) 1979-07-11
FR2184934A1 (fr) 1973-12-28
PH15112A (en) 1982-08-10
DE2636582A1 (de) 1977-02-24
AU5584673A (en) 1974-11-21
CH577461A5 (fr) 1976-07-15
GB1432576A (en) 1976-04-22
DE2324768C2 (de) 1985-08-14
JPS523381B2 (fr) 1977-01-27
GB1521097A (en) 1978-08-09
FR2184934B1 (fr) 1976-11-05
NL183722C (nl) 1989-01-02
AT329542B (de) 1976-05-10
CA1087205A (fr) 1980-10-07
JPS5726585B2 (fr) 1982-06-05
BE837154A (fr) 1976-04-16
DE2324768A1 (de) 1973-11-29
US4182774A (en) 1980-01-08
NL7306833A (fr) 1973-11-20
JPS55349A (en) 1980-01-05
MX4035E (es) 1981-11-18
CA1012979A (en) 1977-06-28
ATA429873A (de) 1975-08-15
SE400966B (sv) 1978-04-17
AU6181480A (en) 1981-01-08
ATA977475A (de) 1978-05-15
US4126635A (en) 1978-11-21
JPS5223052A (en) 1977-02-21
US4045576A (en) 1977-08-30

Similar Documents

Publication Publication Date Title
BE799611A (fr) Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation
BE819189A (fr) Nouveaux acides azacycloalcane-2,2-diphosphoniques et leur procede de preparation
BE819187A (fr) Nouveaux acides pyrrolidone-5,5-diphosphoniques et leur procede de preparation
FR2275451A1 (fr) Nouveaux derives d'acides arylthioalcanoiques, et leur procede de preparation
FR2288089A1 (fr) Nouveaux herbicides et procede de leur preparation
BE819188A (fr) Nouveaux acides aminophosphoniqes cycliques et leur procede de preparation
BE845551A (fr) Acides heteroarylbenzoxepine-acetiques, leur procede de preparation et leur application
FR2285389A1 (fr) Nouveaux multiheteromacrocycles et leur procede de preparation
FR2279709A1 (fr) Nouveaux bicyclooctadienes et leur procede de preparation
FR2303803A1 (fr) Acides sulfothiophene-carboxyliques et leur procede de preparation
BE823973A (fr) Beta-aminoethylsilanes et leur procede de preparation
BE818975A (fr) Derives d'acides phenoxypropioniques et leur procede de preparation
FR2296631A1 (fr) Derives de cyclopentane et leur procede de preparation
BE818055A (fr) Derives de dibenzoxepine et leur procede de preparation
FR2328461A1 (fr) Nouveaux acides phenoxyalcanecarboxyliques et leur procede de preparation
BE823682A (fr) Nouveaux derives de 21-acide de pregnane et leur procede de preparation
BE820385A (fr) D-homo-steroides et leur procede de preparation
FR2313353A1 (fr) Acides omega-amino alcenoiques leur procede de preparation et applications de ces acides
BE782214R (fr) Acides aminomethylenephosphoniques et leur procede de preparation
BE819321A (fr) Nouveaux 2,3-dihydrobenzofuranyl-7-n-methyl-carbamates n-sulfenyles, leur procede de preparation et leur application
BE811370A (fr) Nouveaux antibiotiques et leur procede de preparation
BE826017R (fr) Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
BE814118A (fr) Phenylmethanols et phenylcetones aza-2 cycloalkylmethyl-substitues et leur procede de preparation
BE844977A (fr) Nouveaux nitriles et leur procede de preparation
BE815979A (fr) Nouveaux derives d'acides 15-hydroxyprostanoiques et leur procede de preparation.

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: A.H. ROBINS CY INC. (ETAT DE DELAWARE)

Effective date: 19930516