BE734479A - - Google Patents
Info
- Publication number
- BE734479A BE734479A BE734479DA BE734479A BE 734479 A BE734479 A BE 734479A BE 734479D A BE734479D A BE 734479DA BE 734479 A BE734479 A BE 734479A
- Authority
- BE
- Belgium
- Prior art keywords
- acid
- composition according
- therapeutic composition
- naphthoxy
- isobutyryl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 11
- 230000001225 therapeutic effect Effects 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000829 suppository Substances 0.000 claims description 4
- 239000006188 syrup Substances 0.000 claims description 4
- 235000020357 syrup Nutrition 0.000 claims description 4
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 claims description 2
- 150000007529 inorganic bases Chemical class 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- 239000004552 water soluble powder Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940102223 injectable solution Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000047 product Substances 0.000 description 10
- 241000700159 Rattus Species 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 229960002684 aminocaproic acid Drugs 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000002484 anti-cholesterolemic effect Effects 0.000 description 3
- 230000001989 choleretic effect Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000731 choleretic agent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- -1 naphthoxy-isobutyryl6-aminohexanoic acid Chemical compound 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 231100000027 toxicology Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 description 1
- SUTWPJHCRAITLU-UHFFFAOYSA-N 6-aminohexan-1-ol Chemical compound NCCCCCCO SUTWPJHCRAITLU-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000000713 anti-steatotic effect Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 239000003809 bile pigment Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000035603 choleresis Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 231100000132 chronic toxicity testing Toxicity 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 229960002997 dehydrocholic acid Drugs 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000012495 positive regulation of renal sodium excretion Effects 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE734479 | 1969-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE734479A true BE734479A (d) | 1969-11-17 |
Family
ID=3854896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE734479D BE734479A (d) | 1969-06-12 | 1969-06-12 |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE734479A (d) |
-
1969
- 1969-06-12 BE BE734479D patent/BE734479A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH628344A5 (fr) | Procede de preparation de nouveaux derives du piperidyl-indole et de leurs sels. | |
| CH469659A (fr) | Procédé d'obtention de dérivés du tri-hydroxy-méthyl-aminométhane | |
| CH639369A5 (fr) | Benzamides heterocycliques substitues et leurs procedes de preparation. | |
| EP0349432B1 (fr) | Sel de strontium, son procédé de préparation et les compositions pharmaceutiques le renfermant | |
| CA2112866C (fr) | Nouveaux derives 2-cyano 3-hydroxy propenamides, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant | |
| CA1181340A (fr) | Compositions pharmaceutiques renfermant des derives de l'acide 4-phenyl-4-oxo 2-butenoique | |
| BE897617A (fr) | Thioesters d'acide acetylsalicylique procede pour les preparer et compositions pharmaceutiques qui en renferment | |
| CH631157A5 (fr) | Derives d'acide benzoique, leur procede de preparation et leur application therapeutique. | |
| BE734479A (d) | ||
| CH653332A5 (fr) | Derives du tetrahydropyridin-4-yl indole et leurs sels, leur preparation et les medicaments les renfermant. | |
| CH645115A5 (fr) | Procede pour preparer la chloro-7 methyl-2 dihydro-3,3a 2h,9h-isoxazolo(3,2-b)(benzoxazine-1,3)one-9. | |
| CA1099290A (fr) | Procede de preparation du 7-amino 6,7 dihydro (5h) benzocycloheptene | |
| CH529153A (fr) | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones | |
| EP0005422B1 (fr) | Dérivés d'acides oméga-dialkylalkanoiques, leurs procédés de préparation ainsi que leur utilisation en thérapeutique | |
| CA1123830A (fr) | Procede de preparation de nouveaux esters du methyl-1 piperidinol-4 | |
| FR2332M (d) | ||
| BE897217A (fr) | NOUVEAU MEDICAMENT ANTI-INFLAMMATOIRE, ANALGESIQUE ET ANTIPYRETIQUE A BASE DE (P-CHLOROBENZOYL-1, METHYL- 2- Methoxy-5) Indole-3 Acetate de P-Acetamidophenol | |
| EP0022737B1 (fr) | Imines dérivées de l'amino-5 benzodioxole-1,3 utiles comme médicaments et leur préparation | |
| FR2581996A1 (fr) | Nouveaux derives 6-substitues de 6h-dibenzo(b, d)thiopyranne utiles notamment immunomodulateurs et antiviraux et leur preparation | |
| CH510641A (fr) | Procédé de préparation d'un nouveau dérivé de l'acide a-naphtoxy-isobutyrique | |
| BE884978A (fr) | Nouveaux esters de l'acide benzoique substitue | |
| WO1984001384A1 (fr) | Nouveaux derives carbothio hydroximiques, leurs procedes de preparation et les compositions en renfermant | |
| LU84067A1 (fr) | Nouveau derive de la 2,4-dioxacyclohexanone,procede de sa preparation et medicaments le contenant | |
| LU81891A1 (fr) | Derives d'amino-3 dioxo-2,4(1h,3h)quinazolines,leur procede de preparation et composition therapeutique les contenant | |
| FR2498449A1 (fr) | Acides halogeno biphenyl carboxyliques et leurs sels utiles en therapeutique |