BE696952A - - Google Patents

Info

Publication number
BE696952A
BE696952A BE696952DA BE696952A BE 696952 A BE696952 A BE 696952A BE 696952D A BE696952D A BE 696952DA BE 696952 A BE696952 A BE 696952A
Authority
BE
Belgium
Application number
Inventor
R Duschinsky
W Tautz
A Beaman
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BE696952A publication Critical patent/BE696952A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fats And Perfumes (AREA)
BE696952D 1966-04-18 1967-04-13 BE696952A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54306666A 1966-04-18 1966-04-18
US85755669A 1969-09-12 1969-09-12

Publications (1)

Publication Number Publication Date
BE696952A true BE696952A (de) 1967-10-13

Family

ID=27067226

Family Applications (1)

Application Number Title Priority Date Filing Date
BE696952D BE696952A (de) 1966-04-18 1967-04-13

Country Status (14)

Country Link
US (2) US3505349A (de)
BE (1) BE696952A (de)
CH (3) CH561698A5 (de)
DE (1) DE1695186B2 (de)
DK (1) DK137854B (de)
ES (1) ES339419A1 (de)
FI (1) FI49037C (de)
FR (1) FR6767M (de)
GB (1) GB1138529A (de)
IL (1) IL27805A (de)
NL (1) NL150787B (de)
NO (1) NO124072B (de)
PH (1) PH9423A (de)
SE (1) SE346001B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1079275B (de) * 1958-09-05 1960-04-07 Praemeta Praez Smetall Und Kun Schnepper, insbesondere zur Blutentnahme
FR2054504B1 (de) * 1969-07-18 1973-06-08 Rhone Poulenc Sa
DE2022206C3 (de) * 1970-05-06 1979-01-25 Bayer Ag, 5090 Leverkusen Basisch substituierte Diphenylazolyl-essigsäureester, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US3940484A (en) * 1971-12-07 1976-02-24 The Boots Company Limited Insecticidal compositions and methods of combatting insects using substituted imidazoles
DE2306495A1 (de) * 1973-02-09 1974-08-15 Bayer Ag Fungizide mittel
DE2553021A1 (de) * 1974-12-06 1976-06-10 Sandoz Ag Organische verbindungen, ihre verwendung und herstellung
IE47132B1 (en) * 1977-08-19 1983-12-28 Roche Products Ltd Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture
EP0024023B2 (de) * 1979-08-11 1992-11-11 Bayer Ag Antimykotische Mittel mit höherer Freisetzung der Wirkstoffe
US4371540A (en) * 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US5192784A (en) * 1991-06-03 1993-03-09 Du Pont Merck Pharmaceutical Company Etanidazole injectable solution
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
DE69332741T2 (de) * 1992-11-19 2003-10-02 The University Of Rochester, Rochester Nachweis von hypoxia
US6252087B1 (en) * 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US5721265A (en) * 1994-08-05 1998-02-24 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US7230115B1 (en) 1999-07-21 2007-06-12 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
ATE453627T1 (de) * 1999-07-21 2010-01-15 Univ Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
CN101466676B (zh) * 2006-04-12 2012-07-18 默沙东公司 吡啶基酰胺类t-型钙通道拮抗剂
CA2702126A1 (en) * 2007-10-24 2009-04-30 Merck Sharp & Dohme Corp. Heterocycle amide t-type calcium channel antagonists
WO2009054984A1 (en) * 2007-10-24 2009-04-30 Merck & Co., Inc. Heterocycle phenyl amide t-type calcium channel antagonists
US9655975B2 (en) 2012-02-13 2017-05-23 University Of Tsukuba Prodrug using nitroimidazole
SV2013004584A (es) * 2013-11-19 2015-09-07 Mini De Educacion Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida
WO2017205622A1 (en) * 2016-05-25 2017-11-30 Savant Neglected Diseases, Llc Method of making benznidazole
WO2019240671A1 (es) * 2018-06-11 2019-12-19 Ministerio De Educación, Ciencia Y Tecnología Método de manufactura para la producción de benznidazol y su escalado industrial

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065133A (en) * 1956-09-28 1962-11-20 Rhone Poulenc Sa Imidazoles for the control of histomoniasis
US3037909A (en) * 1960-06-29 1962-06-05 Merck & Co Inc 1-methyl-5-nitroimidazole for enterohepatitis
NL299109A (de) * 1962-11-05

Also Published As

Publication number Publication date
PH9423A (en) 1975-11-14
FI49037C (fi) 1975-03-10
ES339419A1 (es) 1968-05-16
CH565771A5 (de) 1975-08-29
FR6767M (de) 1969-03-10
NL6705439A (de) 1967-10-19
DE1695186A1 (de) 1971-04-08
GB1138529A (en) 1969-01-01
FI49037B (de) 1974-12-02
IL27805A (en) 1972-04-27
DE1695186B2 (de) 1976-12-02
CH553787A (de) 1974-09-13
US3679698A (en) 1972-07-25
CH561698A5 (de) 1975-05-15
SE346001B (de) 1972-06-19
DK137854B (da) 1978-05-22
US3505349A (en) 1970-04-07
NO124072B (de) 1972-02-28
DK137854C (de) 1978-10-23
NL150787B (nl) 1976-09-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: F. HOFFMANN-LA ROCHE & CIE S.A.

Effective date: 19860430