BE558454A - - Google Patents
Info
- Publication number
- BE558454A BE558454A BE558454DA BE558454A BE 558454 A BE558454 A BE 558454A BE 558454D A BE558454D A BE 558454DA BE 558454 A BE558454 A BE 558454A
- Authority
- BE
- Belgium
- Prior art keywords
- solution
- monosodium
- enantiomorph
- glutamate
- optically active
- Prior art date
Links
- 239000000243 solution Substances 0.000 claims description 88
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 54
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 43
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 25
- 239000013078 crystal Substances 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 20
- 235000013922 glutamic acid Nutrition 0.000 claims description 20
- 239000004220 glutamic acid Substances 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 17
- 238000000926 separation method Methods 0.000 claims description 14
- 239000002002 slurry Substances 0.000 claims description 13
- 239000007790 solid phase Substances 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 11
- LPUQAYUQRXPFSQ-AENDTGMFSA-M monosodium D-glutamate Chemical compound [Na+].[O-]C(=O)[C@H]([NH3+])CCC([O-])=O LPUQAYUQRXPFSQ-AENDTGMFSA-M 0.000 claims description 10
- 239000004223 monosodium glutamate Substances 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 229930195714 L-glutamate Natural products 0.000 claims description 8
- PHKGGXPMPXXISP-DFWYDOINSA-N azanium;(4s)-4-amino-5-hydroxy-5-oxopentanoate Chemical class [NH4+].[O-]C(=O)[C@@H]([NH3+])CCC([O-])=O PHKGGXPMPXXISP-DFWYDOINSA-N 0.000 claims description 6
- 150000002307 glutamic acids Chemical class 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 238000001640 fractional crystallisation Methods 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 150000007514 bases Chemical class 0.000 claims 1
- 229960002989 glutamic acid Drugs 0.000 description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 14
- 239000000706 filtrate Substances 0.000 description 14
- 239000002253 acid Substances 0.000 description 10
- 229930182847 D-glutamic acid Natural products 0.000 description 9
- 238000002425 crystallisation Methods 0.000 description 9
- 230000008025 crystallization Effects 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 description 7
- 239000007858 starting material Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000010956 selective crystallization Methods 0.000 description 6
- 235000011121 sodium hydroxide Nutrition 0.000 description 6
- 229930195713 D-glutamate Natural products 0.000 description 5
- GJBHGUUFMNITCI-QTNFYWBSSA-M sodium;(2s)-2-aminopentanedioate;hydron;hydrate Chemical compound O.[Na+].OC(=O)[C@@H](N)CCC([O-])=O GJBHGUUFMNITCI-QTNFYWBSSA-M 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 229940049906 glutamate Drugs 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- RPAJSBKBKSSMLJ-AENDTGMFSA-N (2r)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@H](N)CCC(O)=O RPAJSBKBKSSMLJ-AENDTGMFSA-N 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 229930195712 glutamate Natural products 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 150000004682 monohydrates Chemical class 0.000 description 3
- LPUQAYUQRXPFSQ-UHFFFAOYSA-M monosodium glutamate Chemical compound [Na+].[O-]C(=O)C(N)CCC(O)=O LPUQAYUQRXPFSQ-UHFFFAOYSA-M 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- ZMCBEVWKPOJRPQ-QTNFYWBSSA-N (2s)-2-aminopentanedioic acid;azane;hydrate Chemical compound [NH4+].O.OC(=O)[C@@H](N)CCC([O-])=O ZMCBEVWKPOJRPQ-QTNFYWBSSA-N 0.000 description 2
- RPAJSBKBKSSMLJ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCC(O)=O RPAJSBKBKSSMLJ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-M L-glutamate(1-) Chemical compound [O-]C(=O)[C@@H]([NH3+])CCC([O-])=O WHUUTDBJXJRKMK-VKHMYHEASA-M 0.000 description 1
- 150000008539 L-glutamic acids Chemical class 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 229960003707 glutamic acid hydrochloride Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- WZWGGYFEOBVNLA-UHFFFAOYSA-N sodium;dihydrate Chemical compound O.O.[Na] WZWGGYFEOBVNLA-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE558454A true BE558454A (d) |
Family
ID=181510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE558454D BE558454A (d) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE558454A (d) |
-
0
- BE BE558454D patent/BE558454A/fr unknown
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