BE544260A

BE544260A -

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Publication number: BE544260A
Authority: BE; Belgium
Prior art keywords: medium; fermentation; tetracycline; chloride ions; process according
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French (fr)

Publication of BE544260A publication Critical patent/BE544260A/fr

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238000000855 fermentation Methods 0.000 claims description 85
230000004151 fermentation Effects 0.000 claims description 85
VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 52
OFVLGDICTFRJMM-WESIUVDSSA-N Tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 claims description 49
229960002180 Tetracycline Drugs 0.000 claims description 49
239000004098 Tetracycline Substances 0.000 claims description 49
235000019364 tetracycline Nutrition 0.000 claims description 49
239000000463 material Substances 0.000 claims description 29
235000002017 Zea mays subsp mays Nutrition 0.000 claims description 27
235000005822 corn Nutrition 0.000 claims description 25
235000005824 corn Nutrition 0.000 claims description 25
238000002803 maceration Methods 0.000 claims description 25
238000000034 method Methods 0.000 claims description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
241000186984 Kitasatospora aureofaciens Species 0.000 claims description 13
244000005700 microbiome Species 0.000 claims description 13
239000000126 substance Substances 0.000 claims description 12
238000005342 ion exchange Methods 0.000 claims description 8
235000015097 nutrients Nutrition 0.000 claims description 8
241000187747 Streptomyces Species 0.000 claims description 5
150000001450 anions Chemical class 0.000 claims description 5
-1 phosphate ions Chemical class 0.000 claims description 5
235000021240 caseins Nutrition 0.000 claims description 4
239000010452 phosphate Substances 0.000 claims description 3
102000037197 Anion exchangers Human genes 0.000 claims description 2
108091006437 Anion exchangers Proteins 0.000 claims description 2
150000001768 cations Chemical class 0.000 claims description 2
229940021722 Caseins Drugs 0.000 claims 1
102000011632 Caseins Human genes 0.000 claims 1
108010076119 Caseins Proteins 0.000 claims 1
241000209149 Zea Species 0.000 claims 1
240000008042 Zea mays Species 0.000 description 26
229920005989 resin Polymers 0.000 description 23
239000011347 resin Substances 0.000 description 23
239000000243 solution Substances 0.000 description 22
DHPRQBPJLMKORJ-XRNKAMNCSA-N (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 description 20
230000003115 biocidal Effects 0.000 description 19
239000000203 mixture Substances 0.000 description 19
150000002500 ions Chemical class 0.000 description 14
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 13
239000007788 liquid Substances 0.000 description 12
229920001429 Chelating resin Polymers 0.000 description 11
238000002360 preparation method Methods 0.000 description 11
239000007787 solid Substances 0.000 description 11
HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
125000002091 cationic group Chemical group 0.000 description 7
239000000047 product Substances 0.000 description 7
125000000129 anionic group Chemical group 0.000 description 6
150000001805 chlorine compounds Chemical class 0.000 description 6
239000000470 constituent Substances 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
MUBZPKHOEPUJKR-UHFFFAOYSA-N oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
150000003839 salts Chemical class 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
229960000625 Oxytetracycline Drugs 0.000 description 5
IWVCMVBTMGNXQD-PXOLEDIWSA-N Oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 5
239000004100 Oxytetracycline Substances 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
235000019366 oxytetracycline Nutrition 0.000 description 5
229920001817 Agar Polymers 0.000 description 4
229960003563 Calcium Carbonate Drugs 0.000 description 4
CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
229960004793 Sucrose Drugs 0.000 description 4
239000002253 acid Substances 0.000 description 4
235000010419 agar Nutrition 0.000 description 4
229910052921 ammonium sulfate Inorganic materials 0.000 description 4
235000011130 ammonium sulphate Nutrition 0.000 description 4
239000003242 anti bacterial agent Substances 0.000 description 4
229910000019 calcium carbonate Inorganic materials 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
229910052799 carbon Inorganic materials 0.000 description 4
239000003456 ion exchange resin Substances 0.000 description 4
229920003303 ion-exchange polymer Polymers 0.000 description 4
235000015110 jellies Nutrition 0.000 description 4
LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
229920000768 polyamine Polymers 0.000 description 4
150000003242 quaternary ammonium salts Chemical class 0.000 description 4
239000002904 solvent Substances 0.000 description 4
229940064005 Antibiotic throat preparations Drugs 0.000 description 3
229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 3
229940042052 Antibiotics for systemic use Drugs 0.000 description 3
229940042786 Antitubercular Antibiotics Drugs 0.000 description 3
241000588724 Escherichia coli Species 0.000 description 3
229940093922 Gynecological Antibiotics Drugs 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 3
229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
238000005273 aeration Methods 0.000 description 3
239000003957 anion exchange resin Substances 0.000 description 3
239000002518 antifoaming agent Substances 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000005018 casein Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000012141 concentrate Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000005755 formation reaction Methods 0.000 description 3
229940079866 intestinal antibiotics Drugs 0.000 description 3
239000010699 lard oil Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
229940005935 ophthalmologic Antibiotics Drugs 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
210000004215 spores Anatomy 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
230000001954 sterilising Effects 0.000 description 3
238000004659 sterilization and disinfection Methods 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
239000011573 trace mineral Substances 0.000 description 3
235000013619 trace mineral Nutrition 0.000 description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N Ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
241000206672 Gelidium Species 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
230000036740 Metabolism Effects 0.000 description 2
SQGYOTSLMSWVJD-UHFFFAOYSA-N Silver nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K Tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
239000008272 agar Substances 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
239000001166 ammonium sulphate Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
235000012970 cakes Nutrition 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
235000012343 cottonseed oil Nutrition 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
235000013312 flour Nutrition 0.000 description 2
239000008103 glucose Substances 0.000 description 2
238000003306 harvesting Methods 0.000 description 2
XKUUMWKWUZRRPD-UHFFFAOYSA-N heptan-2-amine;sulfuric acid Chemical compound [O-]S([O-])(=O)=O.CCCCCC(C)[NH3+].CCCCCC(C)[NH3+] XKUUMWKWUZRRPD-UHFFFAOYSA-N 0.000 description 2
239000012535 impurity Substances 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
239000008274 jelly Substances 0.000 description 2
235000009973 maize Nutrition 0.000 description 2
230000004060 metabolic process Effects 0.000 description 2
230000035786 metabolism Effects 0.000 description 2
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L mgso4 Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
239000002366 mineral element Substances 0.000 description 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
235000006408 oxalic acid Nutrition 0.000 description 2
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Inorganic materials [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000011084 recovery Methods 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
NWXMGUDVXFXRIG-WESIUVDSSA-N (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 1
OSCJJMKLQGAGML-UHFFFAOYSA-N 2-[(2-pyridin-1-ium-1-ylacetyl)amino]ethyl propanoate;chloride Chemical compound [Cl-].CCC(=O)OCCNC(=O)C[N+]1=CC=CC=C1 OSCJJMKLQGAGML-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
VBIXEXWLHSRNKB-UHFFFAOYSA-N Ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 description 1
239000004254 Ammonium phosphate Substances 0.000 description 1
235000017060 Arachis glabrata Nutrition 0.000 description 1
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235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
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229920002261 Corn starch Polymers 0.000 description 1
102000016736 Cyclins Human genes 0.000 description 1
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229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
240000007842 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
241000152160 Ira Species 0.000 description 1
RLLDCOSVEUVGTD-UHFFFAOYSA-N O=C.NC(N)=N.NC1=NC(N)=NC(N)=N1 Chemical compound O=C.NC(N)=N.NC1=NC(N)=NC(N)=N1 RLLDCOSVEUVGTD-UHFFFAOYSA-N 0.000 description 1
241000282320 Panthera leo Species 0.000 description 1
210000000582 Semen Anatomy 0.000 description 1
241000872198 Serjania polyphylla Species 0.000 description 1
HKZLPVFGJNLROG-UHFFFAOYSA-M Silver chloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
244000127759 Spondias lutea Species 0.000 description 1
GLDOVTGHNKAZLK-UHFFFAOYSA-N Stearyl alcohol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
238000000862 absorption spectrum Methods 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
CUXSAAMWQXNZQW-UHFFFAOYSA-N acetic acid;butan-1-ol Chemical compound CC(O)=O.CCCCO CUXSAAMWQXNZQW-UHFFFAOYSA-N 0.000 description 1
238000007792 addition Methods 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
229910000148 ammonium phosphate Inorganic materials 0.000 description 1
235000019289 ammonium phosphates Nutrition 0.000 description 1
230000003042 antagnostic Effects 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
125000004432 carbon atoms Chemical group C* 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
239000011651 chromium Substances 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
229910052803 cobalt Inorganic materials 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000005712 crystallization Effects 0.000 description 1
238000002242 deionisation method Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
230000029087 digestion Effects 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000006073 displacement reaction Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000002255 enzymatic Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000002349 favourable Effects 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
239000011346 highly viscous material Substances 0.000 description 1
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238000007654 immersion Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
229910052500 inorganic mineral Chemical class 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
150000003893 lactate salts Chemical class 0.000 description 1
238000011068 load Methods 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
PWHULOQIROXLJO-UHFFFAOYSA-N manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
238000010907 mechanical stirring Methods 0.000 description 1
239000011707 mineral Chemical class 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000006011 modification reaction Methods 0.000 description 1
239000005445 natural product Substances 0.000 description 1
230000001264 neutralization Effects 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
235000021048 nutrient requirements Nutrition 0.000 description 1
230000000050 nutritive Effects 0.000 description 1
230000003287 optical Effects 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
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229910052573 porcelain Inorganic materials 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
238000009738 saturating Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
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150000008163 sugars Chemical class 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
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HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1