BE542827A - - Google Patents

Info

Publication number

BE542827A

BE542827A BE542827DA BE542827A BE 542827 A BE542827 A BE 542827A BE 542827D A BE542827D A BE 542827DA BE 542827 A BE542827 A BE 542827A

Authority

BE

Belgium

Prior art keywords

water

saturated

sep

parts

acid

Prior art date

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 claims description 142
• 229910001868 water Inorganic materials 0.000 claims description 77
• 101710037978 BC_5087 Proteins 0.000 claims description 76
• NSFFHOGKXHRQEW-IYJGLQIGSA-N Thiostrepton Chemical compound C([C@]12C=3SC=C(N=3)C(=O)N[C@H](C(=O)NC(/C=3SCC(N=3)C(=O)N[C@H](C=3SC=C(N=3)C(=O)N[C@H](C=3SC=C(N=3)C1N=1)[C@@H](C)OC(=O)C3=CC(=C4C=CC([C@@H](C4=N3)O)N[C@H](C(N[C@@H](C)C(=O)NC(=C)C(=O)N[C@@H](C)C(=O)N2)=O)[C@@H](C)CC)[C@H](C)O)[C@](C)(O)[C@@H](C)O)=C\C)[C@@H](C)O)CC=1C1=NC(C(=O)NC(=C)C(=O)NC(=C)C(N)=O)=CS1 NSFFHOGKXHRQEW-IYJGLQIGSA-N 0.000 claims description 76
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 69
• HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 66
• 239000000243 solution Substances 0.000 claims description 52
• LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 50
• 239000000126 substance Substances 0.000 claims description 41
• 239000002253 acid Substances 0.000 claims description 36
• 239000000203 mixture Substances 0.000 claims description 34
• 238000000855 fermentation Methods 0.000 claims description 31
• 230000004151 fermentation Effects 0.000 claims description 31
• 239000011780 sodium chloride Substances 0.000 claims description 31
• 238000000034 method Methods 0.000 claims description 29
• 239000002904 solvent Substances 0.000 claims description 27
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 24
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 23
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
• 150000003839 salts Chemical class 0.000 claims description 21
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 20
• 239000007864 aqueous solution Substances 0.000 claims description 19
• CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
• 239000001509 sodium citrate Substances 0.000 claims description 18
• 239000011778 trisodium citrate Substances 0.000 claims description 18
• HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 16
• OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 16
• 150000007513 acids Chemical class 0.000 claims description 15
• 238000004519 manufacturing process Methods 0.000 claims description 15
• DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 14
• 238000001228 spectrum Methods 0.000 claims description 14
• 229910052799 carbon Inorganic materials 0.000 claims description 13
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
• 241000187747 Streptomyces Species 0.000 claims description 12
• 229910052757 nitrogen Inorganic materials 0.000 claims description 12
• OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
• 230000002401 inhibitory effect Effects 0.000 claims description 11
• 235000015097 nutrients Nutrition 0.000 claims description 11
• 238000002360 preparation method Methods 0.000 claims description 11
• 229960000583 Acetic Acid Drugs 0.000 claims description 10
• 230000001747 exhibiting Effects 0.000 claims description 10
• 229910052751 metal Chemical class 0.000 claims description 10
• NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 10
• 239000000284 extract Substances 0.000 claims description 9
• 239000002184 metal Chemical class 0.000 claims description 9
• 229960003067 Cystine Drugs 0.000 claims description 8
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine zwitterion Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims description 8
• POULHZVOKOAJMA-UHFFFAOYSA-N Lauric acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 8
• IOLCXVTUBQKXJR-UHFFFAOYSA-M Potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 8
• 235000001014 amino acid Nutrition 0.000 claims description 8
• 150000001413 amino acids Chemical class 0.000 claims description 8
• 238000000605 extraction Methods 0.000 claims description 8
• 238000002844 melting Methods 0.000 claims description 8
• 150000002739 metals Chemical class 0.000 claims description 8
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 7
• 241000894006 Bacteria Species 0.000 claims description 7
• 239000004471 Glycine Substances 0.000 claims description 7
• 238000010521 absorption reaction Methods 0.000 claims description 7
• 230000015572 biosynthetic process Effects 0.000 claims description 7
• 150000001720 carbohydrates Chemical class 0.000 claims description 7
• 235000014633 carbohydrates Nutrition 0.000 claims description 7
• 230000000694 effects Effects 0.000 claims description 7
• 238000005755 formation reaction Methods 0.000 claims description 7
• 229910052739 hydrogen Inorganic materials 0.000 claims description 7
• 229910052760 oxygen Inorganic materials 0.000 claims description 7
• -1 thrponin Chemical compound 0.000 claims description 7
• 241000192125 Firmicutes Species 0.000 claims description 6
• PHTQWCKDNZKARW-UHFFFAOYSA-N Isoamyl alcohol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims description 6
• XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 6
• 238000007792 addition Methods 0.000 claims description 6
• 235000018417 cysteine Nutrition 0.000 claims description 6
• 239000001257 hydrogen Substances 0.000 claims description 6
• 229940043265 methyl isobutyl ketone Drugs 0.000 claims description 6
• 239000001301 oxygen Substances 0.000 claims description 6
• MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 6
• NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 5
• QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
• XNWFRZJHXBZDAG-UHFFFAOYSA-N ethylene glycol monomethyl ether Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims description 5
• 239000012362 glacial acetic acid Substances 0.000 claims description 5
• YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 5
• PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 4
• 239000005639 Lauric acid Substances 0.000 claims description 4
• VWDWKYIASSYTQR-UHFFFAOYSA-N Sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 4
• 150000002500 ions Chemical class 0.000 claims description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
• 159000000000 sodium salts Chemical class 0.000 claims description 4
• 230000000844 anti-bacterial Effects 0.000 claims description 3
• 238000006243 chemical reaction Methods 0.000 claims description 3
• 239000003814 drug Substances 0.000 claims description 3
• 238000010828 elution Methods 0.000 claims description 3
• 239000000049 pigment Substances 0.000 claims description 3
• KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 3
• 239000011734 sodium Substances 0.000 claims description 3
• 229910052708 sodium Inorganic materials 0.000 claims description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
• 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
• 230000003000 nontoxic Effects 0.000 claims description 2
• 231100000252 nontoxic Toxicity 0.000 claims description 2
• 230000003287 optical Effects 0.000 claims description 2
• 239000011591 potassium Substances 0.000 claims description 2
• 229910052700 potassium Inorganic materials 0.000 claims description 2
• 238000001556 precipitation Methods 0.000 claims description 2
• 239000004317 sodium nitrate Substances 0.000 claims description 2
• 235000010344 sodium nitrate Nutrition 0.000 claims description 2
• XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 12
• UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 12
• ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 10
• 238000000926 separation method Methods 0.000 claims 10
• 210000001736 Capillaries Anatomy 0.000 claims 6
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
• 238000005903 acid hydrolysis reaction Methods 0.000 claims 6
• NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 239000011593 sulfur Substances 0.000 claims 6
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 5
• 239000004473 Threonine Substances 0.000 claims 5
• 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 5
• AMQJEAYHLZJPGS-UHFFFAOYSA-N n-pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims 5
• PGMYKACGEOXYJE-UHFFFAOYSA-N Amyl acetate Chemical compound CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims 4
• JOXIMZWYDAKGHI-UHFFFAOYSA-N P-Toluenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 4
• 229940072049 amyl acetate Drugs 0.000 claims 4
• 238000004458 analytical method Methods 0.000 claims 3
• 238000000921 elemental analysis Methods 0.000 claims 3
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
• CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 2
• 159000000007 calcium salts Chemical class 0.000 claims 2
• XTHFKEDIFFGKHM-UHFFFAOYSA-N dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• YHPMRWZVIQTSFZ-UHFFFAOYSA-N 3,5-difluoro-2-(2-fluorophenyl)pyridine Chemical compound FC1=CC(F)=CN=C1C1=CC=CC=C1F YHPMRWZVIQTSFZ-UHFFFAOYSA-N 0.000 claims 1
• 101710032514 ACTI Proteins 0.000 claims 1
• 102000007469 Actins Human genes 0.000 claims 1
• 108010085238 Actins Proteins 0.000 claims 1
• 241000287523 Ara Species 0.000 claims 1
• 206010060945 Bacterial infection Diseases 0.000 claims 1
• YWGDOWXRIALTES-UHFFFAOYSA-N Bepotastine Chemical compound C1CN(CCCC(=O)O)CCC1OC(C=1N=CC=CC=1)C1=CC=C(Cl)C=C1 YWGDOWXRIALTES-UHFFFAOYSA-N 0.000 claims 1
• 206010011416 Croup infectious Diseases 0.000 claims 1
• 101710013115 HAL Proteins 0.000 claims 1
• 241001298245 Lauria Species 0.000 claims 1
• 101710025856 Rmet_0231 Proteins 0.000 claims 1
• JNYSEDHQJCOWQU-UHFFFAOYSA-N Stepronin Chemical compound OC(=O)CNC(=O)C(C)SC(=O)C1=CC=CS1 JNYSEDHQJCOWQU-UHFFFAOYSA-N 0.000 claims 1
• 241000534944 Thia Species 0.000 claims 1
• 241001367079 Una Species 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• IKHGUXGNUITLKF-UHFFFAOYSA-N acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 1
• 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
• 239000003463 adsorbent Substances 0.000 claims 1
• 230000001580 bacterial Effects 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 201000010549 croup Diseases 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 239000003960 organic solvent Substances 0.000 claims 1
• KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
• 230000001105 regulatory Effects 0.000 claims 1
• 238000005070 sampling Methods 0.000 claims 1
• STECJAGHUSJQJN-USLFZFAMSA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 claims 1
• 239000011800 void material Substances 0.000 claims 1
• 235000010633 broth Nutrition 0.000 description 30
• 239000002609 media Substances 0.000 description 29
• 230000003115 biocidal Effects 0.000 description 21
• 229920001817 Agar Polymers 0.000 description 19
• 239000008272 agar Substances 0.000 description 19
• FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 17
• GUBGYTABKSRVRQ-YOLKTULGSA-N Maltose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@H]1CO)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 GUBGYTABKSRVRQ-YOLKTULGSA-N 0.000 description 14
• 239000007787 solid Substances 0.000 description 13
• 238000001914 filtration Methods 0.000 description 9
• HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
• 239000001963 growth media Substances 0.000 description 8
• 239000000463 material Substances 0.000 description 7
• 239000000725 suspension Substances 0.000 description 7
• 239000007788 liquid Substances 0.000 description 6
• 238000002803 maceration Methods 0.000 description 6
• 210000004215 spores Anatomy 0.000 description 6
• 238000005273 aeration Methods 0.000 description 5
• 235000015278 beef Nutrition 0.000 description 5
• 239000012141 concentrate Substances 0.000 description 5
• 238000004821 distillation Methods 0.000 description 5
• 235000013312 flour Nutrition 0.000 description 5
• 239000002054 inoculum Substances 0.000 description 5
• UCSJYZPVAKXKNQ-HZYVHMACSA-N 1-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
• 229920001353 Dextrin Polymers 0.000 description 4
• 239000004375 Dextrin Substances 0.000 description 4
• 241000209149 Zea Species 0.000 description 4
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
• 229910000019 calcium carbonate Inorganic materials 0.000 description 4
• 235000005822 corn Nutrition 0.000 description 4
• 235000005824 corn Nutrition 0.000 description 4
• 235000019425 dextrin Nutrition 0.000 description 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• 238000010438 heat treatment Methods 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 238000003756 stirring Methods 0.000 description 4
• 229940041514 Candida albicans extract Drugs 0.000 description 3
• CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
• 229960001031 Glucose Drugs 0.000 description 3
• 108010068370 Glutens Proteins 0.000 description 3
• GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 3
• 239000001888 Peptone Substances 0.000 description 3
• 108010080698 Peptones Proteins 0.000 description 3
• 102100014816 SLIRP Human genes 0.000 description 3
• 101700045779 SLIRP Proteins 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
• 229920002472 Starch Polymers 0.000 description 3
• CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 3
• 229960004793 Sucrose Drugs 0.000 description 3
• 240000008529 Triticum aestivum Species 0.000 description 3
• 239000007900 aqueous suspension Substances 0.000 description 3
• 239000007613 bennett's agar Substances 0.000 description 3
• UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
• 229960004106 citric acid Drugs 0.000 description 3
• 238000001816 cooling Methods 0.000 description 3
• 201000009910 diseases by infectious agent Diseases 0.000 description 3
• 239000012153 distilled water Substances 0.000 description 3
• 239000000706 filtrate Substances 0.000 description 3
• 235000021312 gluten Nutrition 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 229910052500 inorganic mineral Inorganic materials 0.000 description 3
• 239000008101 lactose Substances 0.000 description 3
• GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
• 235000010755 mineral Nutrition 0.000 description 3
• 239000011707 mineral Substances 0.000 description 3
• 235000019319 peptone Nutrition 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
• 239000008107 starch Substances 0.000 description 3
• 235000019698 starch Nutrition 0.000 description 3
• 239000005720 sucrose Substances 0.000 description 3
• DKGAVHZHDRPRBM-UHFFFAOYSA-N t-BuOH Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
• 101700082413 tant Proteins 0.000 description 3
• 235000021307 wheat Nutrition 0.000 description 3
• 239000012138 yeast extract Substances 0.000 description 3
• WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
• DHPRQBPJLMKORJ-XRNKAMNCSA-N (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 description 2
• 235000014469 Bacillus subtilis Nutrition 0.000 description 2
• 229940077731 Carbohydrate nutrients Drugs 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• 210000004276 Hyalin Anatomy 0.000 description 2
• 229920001202 Inulin Polymers 0.000 description 2
• 229940029339 Inulin Drugs 0.000 description 2
• JYJIGFIDKWBXDU-MNNPPOADSA-N Inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
• 239000007836 KH2PO4 Substances 0.000 description 2
• GLFNIEUTAYBVOC-UHFFFAOYSA-L MANGANESE CHLORIDE Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• 229910021380 MnCl2 Inorganic materials 0.000 description 2
• GNSKLFRGEWLPPA-UHFFFAOYSA-M Monopotassium phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
• 229960000625 Oxytetracycline Drugs 0.000 description 2
• IWVCMVBTMGNXQD-PXOLEDIWSA-N Oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 2
• 229940049954 Penicillin Drugs 0.000 description 2
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
• 229940083542 Sodium Drugs 0.000 description 2
• 241000193998 Streptococcus pneumoniae Species 0.000 description 2
• 229960005322 Streptomycin Drugs 0.000 description 2
• SRBFZHDQGSBBOR-SQOUGZDYSA-N Xylose Natural products O[C@@H]1CO[C@@H](O)[C@@H](O)[C@@H]1O SRBFZHDQGSBBOR-SQOUGZDYSA-N 0.000 description 2
• 238000009632 agar plate Methods 0.000 description 2
• 150000001479 arabinose derivatives Chemical class 0.000 description 2
• 235000020127 ayran Nutrition 0.000 description 2
• 229960000626 benzylpenicillin Drugs 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 235000013339 cereals Nutrition 0.000 description 2
• 239000007979 citrate buffer Substances 0.000 description 2
• 235000012343 cottonseed oil Nutrition 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 239000008121 dextrose Substances 0.000 description 2
• 229940079593 drugs Drugs 0.000 description 2
• 238000001704 evaporation Methods 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 238000002347 injection Methods 0.000 description 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
• 235000005772 leucine Nutrition 0.000 description 2
• 150000002614 leucines Chemical class 0.000 description 2
• 239000011565 manganese chloride Substances 0.000 description 2
• 235000002867 manganese chloride Nutrition 0.000 description 2
• 235000013372 meat Nutrition 0.000 description 2
• CSNNHWWHGAXBCP-UHFFFAOYSA-L mgso4 Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
• 235000019796 monopotassium phosphate Nutrition 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 239000002244 precipitate Substances 0.000 description 2
• 229910001220 stainless steel Inorganic materials 0.000 description 2
• 239000010935 stainless steel Substances 0.000 description 2
• 230000001988 toxicity Effects 0.000 description 2
• 231100000419 toxicity Toxicity 0.000 description 2
• 238000005292 vacuum distillation Methods 0.000 description 2
• PJVXUVWGSCCGHT-ZPYZYFCMSA-N (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal;(3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO PJVXUVWGSCCGHT-ZPYZYFCMSA-N 0.000 description 1
• ZWDDDMUEPPWHCK-UHFFFAOYSA-N 6-[3-octadec-9-ynoyloxy-2-(1-oxidoethenyloxoniumylidene)propyl]oxoniumylidene-2-(oxidomethyl)-4,5-dioxopyran-3-olate Chemical compound [CH2+]CCCCCCCC#CCCCCCCCC(=O)OCC(=[O+]C([O-])=C)C[O+]=C1OC(C[O-])=C([O-])C(=O)C1=O ZWDDDMUEPPWHCK-UHFFFAOYSA-N 0.000 description 1
• 229960004543 Anhydrous Citric Acid Drugs 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 240000008371 Bacillus subtilis Species 0.000 description 1
• 229940075615 Bacillus subtilis Drugs 0.000 description 1
• 229960003071 Bacitracin Drugs 0.000 description 1
• 108010001478 Bacitracin Proteins 0.000 description 1
• 210000004369 Blood Anatomy 0.000 description 1
• 229960003563 Calcium Carbonate Drugs 0.000 description 1
• 229940016114 Calcium Malate Drugs 0.000 description 1
• OLOZVPHKXALCRI-UHFFFAOYSA-L Calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
• 239000004215 Carbon black (E152) Substances 0.000 description 1
• 229960004475 Chlortetracycline Drugs 0.000 description 1
• 229940001468 Citrate Drugs 0.000 description 1
• ARUVKPQLZAKDPS-UHFFFAOYSA-L Copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 101710007289 Cyan7425_0465 Proteins 0.000 description 1
• 240000008893 Cynodon dactylon Species 0.000 description 1
• GZCGUPFRVQAUEE-KCDKBNATSA-N D-(+)-Galactose Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-KCDKBNATSA-N 0.000 description 1
• GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• 241000091890 Dactylogyrus subtilis Species 0.000 description 1
• WQABCVAJNWAXTE-UHFFFAOYSA-N Dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 description 1
• 235000019733 Fish meal Nutrition 0.000 description 1
• 229960002737 Fructose Drugs 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• FBPFZTCFMRRESA-GUCUJZIJSA-N Galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• 229940093915 Gynecological Organic acids Drugs 0.000 description 1
• CDAISMWEOUEBRE-GPIVLXJGSA-N Inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
• 229960000367 Inositol Drugs 0.000 description 1
• DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• 102000004407 Lactalbumin Human genes 0.000 description 1
• 108090000942 Lactalbumin Proteins 0.000 description 1
• 241000283986 Lepus Species 0.000 description 1
• 210000004185 Liver Anatomy 0.000 description 1
• 241000005139 Lycium andersonii Species 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 241000192041 Micrococcus Species 0.000 description 1
• 210000004080 Milk Anatomy 0.000 description 1
• FEMOMIGRRWSMCU-UHFFFAOYSA-N Ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
• 241000207836 Olea <angiosperm> Species 0.000 description 1
• 239000004100 Oxytetracycline Substances 0.000 description 1
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N Raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
• PNNNRSAQSRJVSB-BXKVDMCESA-N Rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 description 1
• 108091006544 SLC13A2 Proteins 0.000 description 1
• 210000002966 Serum Anatomy 0.000 description 1
• 229960004249 Sodium Acetate Drugs 0.000 description 1
• 229940039790 Sodium Oxalate Drugs 0.000 description 1
• ZNCPFRVNHGOPAG-UHFFFAOYSA-L Sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
• 229940074404 Sodium succinate Drugs 0.000 description 1
• 229940091252 Sodium supplements Drugs 0.000 description 1
• HELHAJAZNSDZJO-UHFFFAOYSA-L Sodium tartrate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)C(O)C([O-])=O HELHAJAZNSDZJO-UHFFFAOYSA-L 0.000 description 1
• 229960002167 Sodium tartrate Drugs 0.000 description 1
• 235000019764 Soybean Meal Nutrition 0.000 description 1
• 229910000831 Steel Inorganic materials 0.000 description 1
• WPLOVIFNBMNBPD-ATHMIXSHSA-N Subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
• 229940063650 Terramycin Drugs 0.000 description 1
• 241001125862 Tinca tinca Species 0.000 description 1
• 241001106462 Ulmus Species 0.000 description 1
• 240000004767 Urtica dioica Species 0.000 description 1
• 235000009108 Urtica dioica Nutrition 0.000 description 1
• 239000005862 Whey Substances 0.000 description 1
• 229960003487 Xylose Drugs 0.000 description 1
• NWONKYPBYAMBJT-UHFFFAOYSA-L Zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
• JPXZQMKKFWMMGK-KQYNXXCUSA-N [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 JPXZQMKKFWMMGK-KQYNXXCUSA-N 0.000 description 1
• 238000000862 absorption spectrum Methods 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 239000002518 antifoaming agent Substances 0.000 description 1
• CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
• 239000002585 base Substances 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 239000006161 blood agar Substances 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 101700059128 bre-3 Proteins 0.000 description 1
• 239000001058 brown pigment Substances 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 235000012970 cakes Nutrition 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 239000001362 calcium malate Substances 0.000 description 1
• 235000013962 calcium malate Nutrition 0.000 description 1
• 150000001721 carbon Chemical class 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 239000003610 charcoal Substances 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 230000000973 chemotherapeutic Effects 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 235000019365 chlortetracycline Nutrition 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 231100000160 chronic toxicity Toxicity 0.000 description 1
• 230000015271 coagulation Effects 0.000 description 1
• 238000005345 coagulation Methods 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
• 239000012045 crude solution Substances 0.000 description 1
• 239000012531 culture fluid Substances 0.000 description 1
• 230000002478 diastatic Effects 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 238000007865 diluting Methods 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 238000003113 dilution method Methods 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• ZDQYSKICYIVCPN-UHFFFAOYSA-L disodium butanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
• 238000006073 displacement reaction Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 239000004467 fishmeal Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 239000001056 green pigment Substances 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 229910052736 halogen Inorganic materials 0.000 description 1
• 150000002367 halogens Chemical class 0.000 description 1
• 235000019534 high fructose corn syrup Nutrition 0.000 description 1
• 150000002430 hydrocarbons Chemical class 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxyl anion Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 238000007689 inspection Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
• 235000019341 magnesium sulphate Nutrition 0.000 description 1
• 229940049920 malate Drugs 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 1
• 229960001855 mannitol Drugs 0.000 description 1
• 235000012054 meals Nutrition 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000002503 metabolic Effects 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
• IOVCWXUNBOPUCH-UHFFFAOYSA-M nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
• 231100000956 nontoxicity Toxicity 0.000 description 1
• 239000006877 oatmeal agar Substances 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 210000000056 organs Anatomy 0.000 description 1
• 235000019366 oxytetracycline Nutrition 0.000 description 1
• 230000001717 pathogenic Effects 0.000 description 1
• OFBQJSOFQDEBGM-UHFFFAOYSA-N pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011574 phosphorus Substances 0.000 description 1
• 235000021395 porridge Nutrition 0.000 description 1
• 239000001965 potato dextrose agar Substances 0.000 description 1
• 238000010298 pulverizing process Methods 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 239000002002 slurry Substances 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 239000001433 sodium tartrate Substances 0.000 description 1
• 235000011004 sodium tartrates Nutrition 0.000 description 1
• 239000008279 sol Substances 0.000 description 1
• 239000011343 solid material Substances 0.000 description 1
• 238000007711 solidification Methods 0.000 description 1
• 239000004455 soybean meal Substances 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 230000028070 sporulation Effects 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000010959 steel Substances 0.000 description 1
• 230000001954 sterilising Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 108010082567 subtilin Proteins 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
• 235000020275 sunflower milk Nutrition 0.000 description 1
• 230000001225 therapeutic Effects 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 229910052718 tin Inorganic materials 0.000 description 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N tin hydride Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
• NRTOMJZYCJJWKI-UHFFFAOYSA-N titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
• 235000015193 tomato juice Nutrition 0.000 description 1
• 239000012137 tryptone Substances 0.000 description 1
• 201000008827 tuberculosis Diseases 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 239000012224 working solution Substances 0.000 description 1
• 229910000368 zinc sulfate Inorganic materials 0.000 description 1
• 239000011686 zinc sulphate Substances 0.000 description 1
• 235000009529 zinc sulphate Nutrition 0.000 description 1