BE518622A - - Google Patents
Info
- Publication number
- BE518622A BE518622A BE518622DA BE518622A BE 518622 A BE518622 A BE 518622A BE 518622D A BE518622D A BE 518622DA BE 518622 A BE518622 A BE 518622A
- Authority
- BE
- Belgium
- Prior art keywords
- amino
- lower alkyl
- general formula
- radical
- halogen
- Prior art date
Links
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims description 2
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims description 2
- 241001182492 Nes Species 0.000 claims 1
- 150000002357 guanidines Chemical class 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000002844 melting Methods 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N Amino radical Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 description 2
- 241000192132 Leuconostoc Species 0.000 description 2
- VVIAGPKUTFNRDU-ZGTCLIOFSA-N Pteroyl-D-glutamic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ZGTCLIOFSA-N 0.000 description 2
- 229940083082 Pyrimidine derivatives acting on arteriolar smooth muscle Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 150000003230 pyrimidines Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- SWXXKWPYNMZFTE-UHFFFAOYSA-N (C-ethylsulfanylcarbonimidoyl)azanium;bromide Chemical compound Br.CCSC(N)=N SWXXKWPYNMZFTE-UHFFFAOYSA-N 0.000 description 1
- NKRGJBDEEGULAN-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-oxopentanenitrile Chemical compound CCC(=O)C(C#N)C1=CC=C(Cl)C=C1 NKRGJBDEEGULAN-UHFFFAOYSA-N 0.000 description 1
- -1 3, 4-dichlorphenyl Chemical group 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001024304 Mino Species 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000078 anti-malarial Effects 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE518622A true BE518622A (pt) |
Family
ID=155115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE518622D BE518622A (pt) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE518622A (pt) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0251083A2 (de) * | 1986-06-21 | 1988-01-07 | BASF Aktiengesellschaft | 4-Aminopyrimidinderivate |
| EP0459819A2 (en) * | 1990-06-01 | 1991-12-04 | The Wellcome Foundation Limited | Pharmacologically active CNS compound |
| WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| US5459158A (en) * | 1992-12-18 | 1995-10-17 | Burroughs Wellcome Co. | Pharmaceutical compositions of indazoles and methods of use thereof |
| US5597828A (en) * | 1988-12-07 | 1997-01-28 | Glaxo Wellcome Inc. | Certain 2,4-diamino-5-(2,3-dihalophenyl)-6-substituted pyrimidines which are pharmacologically active CNS compounds |
| WO2002074753A3 (de) * | 2001-03-15 | 2002-12-27 | Basf Ag | 5-phenylpyrimidine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von schadpilzen |
-
0
- BE BE518622D patent/BE518622A/fr unknown
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0251083A2 (de) * | 1986-06-21 | 1988-01-07 | BASF Aktiengesellschaft | 4-Aminopyrimidinderivate |
| EP0251083A3 (en) * | 1986-06-21 | 1988-03-23 | Basf Aktiengesellschaft | 4-amino-pyrimidine derivatives |
| US5597828A (en) * | 1988-12-07 | 1997-01-28 | Glaxo Wellcome Inc. | Certain 2,4-diamino-5-(2,3-dihalophenyl)-6-substituted pyrimidines which are pharmacologically active CNS compounds |
| US5684005A (en) * | 1988-12-07 | 1997-11-04 | Glaxo Wellcome Inc. | Pharmacologically active CNS compounds |
| EP0459819A2 (en) * | 1990-06-01 | 1991-12-04 | The Wellcome Foundation Limited | Pharmacologically active CNS compound |
| EP0459819A3 (en) * | 1990-06-01 | 1992-03-11 | The Wellcome Foundation Limited | Pharmacologically active cns compounds |
| WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| US5459158A (en) * | 1992-12-18 | 1995-10-17 | Burroughs Wellcome Co. | Pharmaceutical compositions of indazoles and methods of use thereof |
| WO2002074753A3 (de) * | 2001-03-15 | 2002-12-27 | Basf Ag | 5-phenylpyrimidine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von schadpilzen |
| US7153860B2 (en) | 2001-03-15 | 2006-12-26 | Basf Aktiengesellschaft | 5-Phenylpyrimidines, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi |
| EA007719B1 (ru) * | 2001-03-15 | 2006-12-29 | Басф Акциенгезельшафт | 5-фенилпиримидины, способ и промежуточные продукты для их получения и их применение для борьбы с фитопатогенными грибами |
| US7709637B2 (en) | 2001-03-15 | 2010-05-04 | Basf Se | 5-phenylpyrimidines, their preparation, intermediates for their preparation, and their use for controlling harmful fungi |
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