BE486193A - - Google Patents
Info
- Publication number
- BE486193A BE486193A BE486193DA BE486193A BE 486193 A BE486193 A BE 486193A BE 486193D A BE486193D A BE 486193DA BE 486193 A BE486193 A BE 486193A
- Authority
- BE
- Belgium
- Prior art keywords
- lactoflavin
- solution
- vitamin
- gentisic
- water
- Prior art date
Links
- 229960002477 Riboflavin Drugs 0.000 claims description 34
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 34
- 239000002904 solvent Substances 0.000 claims description 17
- WXTMDXOMEHJXQO-UHFFFAOYSA-N Gentisic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 16
- 150000001408 amides Chemical class 0.000 claims description 13
- 229930003451 Vitamin B1 Natural products 0.000 claims description 8
- 229960005219 gentisic acid Drugs 0.000 claims description 8
- 229960003495 thiamine Drugs 0.000 claims description 8
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 8
- 235000010374 vitamin B1 Nutrition 0.000 claims description 8
- 239000011691 vitamin B1 Substances 0.000 claims description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000243 solution Substances 0.000 description 18
- 239000000203 mixture Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 229940029983 VITAMINS Drugs 0.000 description 4
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229930003231 vitamins Natural products 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 3
- 229940068459 SODIUM PANTOTHENATE Drugs 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 150000003700 vitamin C derivatives Chemical class 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N Gallic acid Natural products OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- TYQCGQRIZGCHNB-JLAZNSOCSA-N L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 2
- 229960005055 SODIUM ASCORBATE Drugs 0.000 description 2
- 229940011671 Vitamin B6 Drugs 0.000 description 2
- 229930003629 Vitamin B6 Natural products 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- -1 for example Natural products 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000010378 sodium ascorbate Nutrition 0.000 description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 239000011726 vitamin B6 Substances 0.000 description 2
- 235000019158 vitamin B6 Nutrition 0.000 description 2
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 2
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-Amino-2-propanol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 1
- SYNHCENRCUAUNM-UHFFFAOYSA-N 2-chloro-N-(2-chloroethyl)-N-methylethanamine oxide;hydron;chloride Chemical compound Cl.ClCC[N+]([O-])(C)CCCl SYNHCENRCUAUNM-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229940055726 Pantothenic Acid Drugs 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229940046001 Vitamin B Complex Drugs 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 206010047627 Vitamin deficiency Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000004202 carbamide Chemical class 0.000 description 1
- 125000004432 carbon atoms Chemical group C* 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- WCQOBLXWLRDEQA-UHFFFAOYSA-N ethanimidamide;hydrochloride Chemical compound Cl.CC(N)=N WCQOBLXWLRDEQA-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N ethanolamine Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- GCUPAENRSCPHBM-UHFFFAOYSA-N ethyl 2,5-dihydroxybenzoate Chemical compound CCOC(=O)C1=CC(O)=CC=C1O GCUPAENRSCPHBM-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 230000001771 impaired Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N pantothenic acid Natural products OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE486193A true BE486193A (sv) |
Family
ID=131923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE486193D BE486193A (sv) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE486193A (sv) |
-
0
- BE BE486193D patent/BE486193A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2141704C (fr) | Solutions aqueuses concentrees d'argatroban | |
| CA2102777C (fr) | Nouvelles compositions a base de derives de la classe des taxanes | |
| EP0671912B1 (fr) | Compositions injectables a base de derives des taxanes | |
| CH630260A5 (fr) | Compositions antibiotiques a base d'une tetracycline. | |
| CA2247520C (fr) | Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree | |
| CA2469028C (fr) | Composition pharmaceutique sous forme de gel ou de solution a base de dihydrotestosterone, son procede de preparation et ses utilisations | |
| CH616080A5 (sv) | ||
| FR2948568A1 (fr) | Formulation pharmaceutique | |
| CH646412A5 (fr) | Procede de preparation des produits hydrosolubles a base de (+)-catechine et compositions contenant ces produits. | |
| FR2681863A1 (fr) | Solution de sparfloxacine sa preparation et sel la constituant. | |
| CH644015A5 (fr) | Solution aqueuse injectable a base d'oxytetracycline. | |
| BE486193A (sv) | ||
| LU83363A1 (fr) | Compositions antitumeurs | |
| EP0575481B1 (fr) | Nouvelles compositions liquides a base de derives de la piperidine substitues en 1,4 | |
| CA2454150A1 (fr) | Formulation galenique injectable pour utilisation dans un diagnostic ou une therapie photodynamique et son procede de preparation | |
| FR2609714A1 (fr) | Compositions liquides stables a base de derives antifongiques imidazoles | |
| EP0425362A2 (fr) | Sels de furosémide, procédé de préparation, application comme médicaments et compositions pharmaceutiques les renfermant | |
| FR2739778A1 (fr) | Formulation topique destinee a traiter la maladie de la douve du foie chez l'animal | |
| BE385316A (sv) | ||
| BE558299A (sv) | ||
| BE536866A (sv) | ||
| BE627717A (sv) | ||
| BE499762A (sv) | ||
| BE528966A (sv) | ||
| BE572443A (sv) |