BE2015C066I2 - - Google Patents

Download PDF

Info

Publication number
BE2015C066I2
BE2015C066I2 BE2015C066C BE2015C066C BE2015C066I2 BE 2015C066 I2 BE2015C066 I2 BE 2015C066I2 BE 2015C066 C BE2015C066 C BE 2015C066C BE 2015C066 C BE2015C066 C BE 2015C066C BE 2015C066 I2 BE2015C066 I2 BE 2015C066I2
Authority
BE
Belgium
Application number
BE2015C066C
Other languages
Dutch (nl)
Original Assignee
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme Llc
Publication of BE2015C066I2 publication Critical patent/BE2015C066I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE2015C066C 2004-03-24 2015-12-09 BE2015C066I2 (en, 2012)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55592604P 2004-03-24 2004-03-24

Publications (1)

Publication Number Publication Date
BE2015C066I2 true BE2015C066I2 (en, 2012) 2024-08-08

Family

ID=34964085

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C066C BE2015C066I2 (en, 2012) 2004-03-24 2015-12-09

Country Status (31)

Country Link
US (2) US7700103B2 (en, 2012)
EP (1) EP1730175B1 (en, 2012)
JP (1) JP4833962B2 (en, 2012)
KR (1) KR101203403B1 (en, 2012)
CN (1) CN1934131B (en, 2012)
AR (1) AR048191A1 (en, 2012)
AT (1) ATE466022T1 (en, 2012)
AU (1) AU2005230907C1 (en, 2012)
BE (1) BE2015C066I2 (en, 2012)
BR (1) BRPI0509079B8 (en, 2012)
CA (1) CA2560487C (en, 2012)
CY (2) CY1110349T1 (en, 2012)
DE (1) DE602005020913D1 (en, 2012)
DK (1) DK1730175T3 (en, 2012)
ES (1) ES2343255T3 (en, 2012)
FR (1) FR15C0085I2 (en, 2012)
HU (1) HUS1500062I1 (en, 2012)
IL (1) IL178140A (en, 2012)
LT (2) LTPA2015050I1 (en, 2012)
LU (1) LU92903I2 (en, 2012)
MY (1) MY148656A (en, 2012)
NL (1) NL300777I2 (en, 2012)
NO (3) NO338055B1 (en, 2012)
NZ (1) NZ549898A (en, 2012)
PL (1) PL1730175T3 (en, 2012)
PT (1) PT1730175E (en, 2012)
RU (1) RU2373219C2 (en, 2012)
SI (1) SI1730175T1 (en, 2012)
TW (1) TWI349036B (en, 2012)
WO (1) WO2005097821A1 (en, 2012)
ZA (1) ZA200607575B (en, 2012)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
CN1869215B (zh) * 2006-05-19 2012-07-04 长春百克生物科技股份公司 一种制备人乳头瘤病毒的病毒样颗粒的方法
AU2008226974B2 (en) 2007-03-09 2013-08-15 Merck Sharp & Dohme Llc Papillomavirus vaccine compositions
CN101440371B (zh) * 2007-11-23 2012-09-05 上海泽润生物科技有限公司 一种16型人乳头状瘤病毒主要衣壳蛋白l1基因
EP2479186B1 (en) * 2007-11-23 2015-08-12 Shanghai Zerun Biotechnology Co., Ltd. Genes encoding major capsid protein L1 of human papilloma viruses
MX348113B (es) * 2010-05-14 2017-05-29 Baxalta Inc Genes ospa quimericos, proteinas, y metodos para usar los mismos.
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
DK2589604T3 (en) 2010-07-02 2017-01-16 Univ Xiamen TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
BR112013013377A2 (pt) 2010-12-03 2016-11-22 Ms Technologies Llc molécula de ácido nucléico codificante de uma sintase de ácido 5-enolpiruvil-3-fosfo-chiquímico (epsps), constructo, vetor, célula de planta, planta, método para produzir uma planta tendo
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
RU2445357C1 (ru) * 2011-02-15 2012-03-20 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 16
RU2445358C1 (ru) * 2011-02-15 2012-03-20 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантный штамм дрожжей pichia angusta - продуцент капсидного белка l1 вируса папилломы человека типа 18
CN104120089B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN110592133A (zh) * 2013-05-17 2019-12-20 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
EP3057612B1 (en) 2013-10-16 2020-05-06 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
CN106701796B (zh) * 2015-08-12 2021-11-16 北京康乐卫士生物技术股份有限公司 52型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750049B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒52亚型蛋白表达
CA3166256A1 (en) 2020-02-14 2021-08-19 Marian E. Gindy Human papillomavirus (hpv) virus-like particles (vlps) vaccine
CN114539365B (zh) * 2020-11-26 2023-12-01 中国医学科学院基础医学研究所 一种改造的人乳头瘤病毒52型l1蛋白及其用途
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
AR126708A1 (es) 2021-08-06 2023-11-08 Merck Sharp & Dohme Llc Vacuna para el vph
CA3229064A1 (en) 2021-08-19 2023-02-23 Andrew Bett Thermostable lipid nanoparticle and methods of use thereof
WO2024254226A1 (en) 2023-06-09 2024-12-12 Merck Sharp & Dohme Llc Nanoemulsion adjuvant compositions for human papillomavirus vaccines

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339729C (en) * 1988-10-26 1998-03-17 Wayne D. Lancaster Human papillomavirus type 52 dna sequences and methods for employing thesame
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US5821087A (en) * 1995-03-30 1998-10-13 Merck & Co., Inc. Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
JP2001512308A (ja) 1997-02-07 2001-08-21 メルク エンド カンパニー インコーポレーテッド 合成ｈｉｖ ｇａｇ遺伝子
CA2296067C (en) 1997-07-09 2008-10-07 The University Of Queensland Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
SI1105466T1 (sl) * 1998-08-14 2006-08-31 Merck & Co Inc Postopek za ciscenje virusu podobnih delcev humanega papilomskega virusa
AU753391B2 (en) 1998-08-14 2002-10-17 Merck Sharp & Dohme Corp. Protein delivery system using human papillomavirus virus-like particles
SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
DE60016765T2 (de) 1999-08-25 2005-11-24 Merck & Co., Inc. Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind
US6436402B1 (en) 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
JP2004504057A (ja) 2000-07-21 2004-02-12 グラクソ　グループ　リミテッド コドン最適化されたパピローマウイルス配列
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
NZ542246A (en) * 2003-03-24 2007-12-21 Merck & Co Inc Optimized expression of HPV 31 L1 yeast
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast

Also Published As

Publication number Publication date
NL300777I1 (en, 2012) 2015-12-29
FR15C0085I2 (fr) 2016-11-25
KR101203403B1 (ko) 2012-11-21
US7700103B2 (en) 2010-04-20
HUS1500062I1 (hu) 2017-07-28
CY1110349T1 (el) 2015-04-29
LU92903I2 (fr) 2016-03-08
ZA200607575B (en) 2008-08-27
AU2005230907C1 (en) 2016-07-28
CY2015052I1 (el) 2016-06-22
BRPI0509079B8 (pt) 2021-07-06
CN1934131B (zh) 2010-12-29
DK1730175T3 (da) 2010-08-23
PT1730175E (pt) 2010-06-25
RU2006137363A (ru) 2008-04-27
US7744892B2 (en) 2010-06-29
BRPI0509079A (pt) 2007-08-21
IL178140A0 (en) 2006-12-31
NL300777I2 (en, 2012) 2015-12-29
FR15C0085I1 (en, 2012) 2016-08-01
DE602005020913D1 (de) 2010-06-10
IL178140A (en) 2010-11-30
LTC1730175I2 (lt) 2017-05-10
LTPA2015050I1 (lt) 2016-01-11
NO2022050I1 (no) 2022-11-30
EP1730175A1 (en) 2006-12-13
ES2343255T3 (es) 2010-07-27
BRPI0509079B1 (pt) 2020-05-19
CA2560487A1 (en) 2005-10-20
JP4833962B2 (ja) 2011-12-07
PL1730175T3 (pl) 2010-09-30
AR048191A1 (es) 2006-04-05
AU2005230907A1 (en) 2005-10-20
ATE466022T1 (de) 2010-05-15
WO2005097821A1 (en) 2005-10-20
RU2373219C2 (ru) 2009-11-20
EP1730175B1 (en) 2010-04-28
CA2560487C (en) 2013-01-29
NO20064815L (no) 2006-10-23
CY2015052I2 (el) 2016-06-22
JP2007530040A (ja) 2007-11-01
MY148656A (en) 2013-05-15
KR20060134120A (ko) 2006-12-27
AU2005230907B2 (en) 2011-05-19
NO2017005I1 (no) 2017-01-20
TW200602490A (en) 2006-01-16
US20100035818A1 (en) 2010-02-11
NZ549898A (en) 2009-06-26
TWI349036B (en) 2011-09-21
SI1730175T1 (sl) 2010-08-31
US20080226660A1 (en) 2008-09-18
CN1934131A (zh) 2007-03-21
NO338055B1 (no) 2016-07-25

Similar Documents

Publication Publication Date Title
BE2024C508I2 (en, 2012)
BE2022C549I2 (en, 2012)
BE2023C542I2 (en, 2012)
BE2021C001I2 (en, 2012)
BE2020C513I2 (en, 2012)
BE2020C517I2 (en, 2012)
BE2019C540I2 (en, 2012)
BE2019C523I2 (en, 2012)
BE2019C506I2 (en, 2012)
BE2019C548I2 (en, 2012)
BE2018C045I2 (en, 2012)
BE2017C063I2 (en, 2012)
BE2020C525I2 (en, 2012)
BE2017C027I2 (en, 2012)
BE2017C023I2 (en, 2012)
BE2017C002I2 (en, 2012)
BE2016C067I2 (en, 2012)
BE2016C014I2 (en, 2012)
BE2015C066I2 (en, 2012)
BE2019C535I2 (en, 2012)
JP2004332738A5 (en, 2012)
JP2004254308A5 (en, 2012)
BE2016C042I2 (en, 2012)
BE2016C035I2 (en, 2012)
JP2004332731A5 (en, 2012)