BE1000729A4 - POLYPEPTIDE FOR USE IN THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KIT FOR THE DETECTION OF MALARIAN CONDITIONS, METHOD FOR THE PREPARATION THEREOF AND THE USE THEREOF. - Google Patents
POLYPEPTIDE FOR USE IN THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KIT FOR THE DETECTION OF MALARIAN CONDITIONS, METHOD FOR THE PREPARATION THEREOF AND THE USE THEREOF. Download PDFInfo
- Publication number
- BE1000729A4 BE1000729A4 BE8700769A BE8700769A BE1000729A4 BE 1000729 A4 BE1000729 A4 BE 1000729A4 BE 8700769 A BE8700769 A BE 8700769A BE 8700769 A BE8700769 A BE 8700769A BE 1000729 A4 BE1000729 A4 BE 1000729A4
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- detection
- polypeptide
- malarian
- conditions
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000009007 Diagnostic Kit Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 201000004792 malaria Diseases 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003252 repetitive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Polypeptide utilisable pour la préparation de vaccins antipaludéens et de nécessaires de diagnostic pour la détection d'anticorps antisporozoites dans des échantillons cliniques prélevés sur des sujets atteints de paludisme, constitué d'un peptide synthétique qui répète la Région I de P. falciparum et d'un ensemble formé par un nombre variable d'unités tétra peptidiques répétitives de protéine CS de P. falciuparum, liés l'un à l'autre par une liaison amide entre l'extrémité proline de la Région I et l'asparagine de tete du premier tétrapeptide.Polypeptide usable for the preparation of antimalarial vaccines and diagnostic kits for the detection of antisporozoite antibodies in clinical samples taken from subjects suffering from malaria, consisting of a synthetic peptide which repeats Region I of P. falciparum and a set formed by a variable number of repetitive tetra peptide units of P. falciuparum CS protein, linked to each other by an amide bond between the proline end of Region I and the head asparagine of the first tetrapeptide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21144/86A IT1196501B (en) | 1986-07-16 | 1986-07-16 | POLYPEPTIDE USEFUL FOR THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KITS FOR THE DETERMINATION OF MALARIC DISEASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1000729A4 true BE1000729A4 (en) | 1989-03-21 |
Family
ID=11177390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE8700769A BE1000729A4 (en) | 1986-07-16 | 1987-07-13 | POLYPEPTIDE FOR USE IN THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KIT FOR THE DETECTION OF MALARIAN CONDITIONS, METHOD FOR THE PREPARATION THEREOF AND THE USE THEREOF. |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | ATA179087A (en) |
| BE (1) | BE1000729A4 (en) |
| CH (1) | CH673461A5 (en) |
| DE (1) | DE3723583A1 (en) |
| ES (1) | ES2008151A6 (en) |
| FR (1) | FR2601590B1 (en) |
| GB (1) | GB2193215B (en) |
| GR (1) | GR871021B (en) |
| IT (1) | IT1196501B (en) |
| NL (1) | NL8701686A (en) |
| OA (1) | OA08626A (en) |
| SE (1) | SE468393B (en) |
| ZA (1) | ZA874778B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68907045T2 (en) * | 1989-01-17 | 1993-12-02 | Eniricerche Spa | Synthetic peptides and their use as general carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines. |
| CA2031468A1 (en) * | 1989-12-08 | 1991-06-09 | Mitchell S. Gross | Malaria vaccine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0166410A2 (en) * | 1984-06-26 | 1986-01-02 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
| WO1986005790A1 (en) * | 1985-03-28 | 1986-10-09 | New York University | Immunogenic antigen-carrier protein conjugate for use in a vaccine against malaria |
| EP0209643A2 (en) * | 1985-07-25 | 1987-01-28 | ENIRICERCHE S.p.A. | Peptide composition useful for the malaria vaccine manufacture as well as for the preparation of diagnostic kits for the detection of malarial diseases |
-
1986
- 1986-07-16 IT IT21144/86A patent/IT1196501B/en active
-
1987
- 1987-06-30 GR GR871021A patent/GR871021B/en unknown
- 1987-06-30 SE SE8702698A patent/SE468393B/en not_active IP Right Cessation
- 1987-07-01 ZA ZA874778A patent/ZA874778B/en unknown
- 1987-07-02 CH CH2506/87A patent/CH673461A5/it not_active IP Right Cessation
- 1987-07-03 GB GB8715737A patent/GB2193215B/en not_active Expired - Lifetime
- 1987-07-03 OA OA59154A patent/OA08626A/en unknown
- 1987-07-13 BE BE8700769A patent/BE1000729A4/en not_active IP Right Cessation
- 1987-07-14 ES ES8702234A patent/ES2008151A6/en not_active Expired
- 1987-07-15 FR FR878709960A patent/FR2601590B1/en not_active Expired - Lifetime
- 1987-07-15 AT AT0179087A patent/ATA179087A/en not_active IP Right Cessation
- 1987-07-16 DE DE19873723583 patent/DE3723583A1/en active Granted
- 1987-07-16 NL NL8701686A patent/NL8701686A/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0166410A2 (en) * | 1984-06-26 | 1986-01-02 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor |
| WO1986005790A1 (en) * | 1985-03-28 | 1986-10-09 | New York University | Immunogenic antigen-carrier protein conjugate for use in a vaccine against malaria |
| EP0209643A2 (en) * | 1985-07-25 | 1987-01-28 | ENIRICERCHE S.p.A. | Peptide composition useful for the malaria vaccine manufacture as well as for the preparation of diagnostic kits for the detection of malarial diseases |
Non-Patent Citations (2)
| Title |
|---|
| JOURNAL OF THE CHEMICAL SOCIETY, Chemical Communications, vol. 1, 1978, pages 537-539; E. ATHERTON et al.: "A mild procedure for solid phase peptide synthesis: use of fluorenylmethoxycarbonylamino-acids" * |
| PERSPECTIVE IN PEPTIDE CHEMISTRY, 1981, pages 101-117, Karger, Bâle, CH; E. ATHERTON et al.: "The solid phase in solid-phase synthesis" * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2601590A1 (en) | 1988-01-22 |
| DE3723583A1 (en) | 1988-01-28 |
| SE8702698D0 (en) | 1987-06-30 |
| ATA179087A (en) | 1996-07-15 |
| ZA874778B (en) | 1988-01-13 |
| NL8701686A (en) | 1988-02-16 |
| GB2193215B (en) | 1990-03-07 |
| IT8621144A0 (en) | 1986-07-16 |
| OA08626A (en) | 1988-11-30 |
| ES2008151A6 (en) | 1989-07-16 |
| DE3723583C2 (en) | 1991-06-13 |
| GB8715737D0 (en) | 1987-08-12 |
| IT1196501B (en) | 1988-11-16 |
| SE468393B (en) | 1993-01-11 |
| GR871021B (en) | 1987-11-13 |
| GB2193215A (en) | 1988-02-03 |
| FR2601590B1 (en) | 1990-05-18 |
| CH673461A5 (en) | 1990-03-15 |
| SE8702698L (en) | 1988-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: ENIRICERCHE S.P.A. Effective date: 19950731 |