ATE120800T1 - ANTIGEN PROTEIN OF THE SPOROZOITE AND HEPATIC PHASE OF P. FALCIPARUM. - Google Patents

ANTIGEN PROTEIN OF THE SPOROZOITE AND HEPATIC PHASE OF P. FALCIPARUM.

Info

Publication number
ATE120800T1
ATE120800T1 AT90400985T AT90400985T ATE120800T1 AT E120800 T1 ATE120800 T1 AT E120800T1 AT 90400985 T AT90400985 T AT 90400985T AT 90400985 T AT90400985 T AT 90400985T AT E120800 T1 ATE120800 T1 AT E120800T1
Authority
AT
Austria
Prior art keywords
glu
lys
ser
asp
gly
Prior art date
Application number
AT90400985T
Other languages
German (de)
Inventor
Pierre Druilhe
Claudine Guerin-Marchand
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE120800T1 publication Critical patent/ATE120800T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to a polypeptide which contains at least one peptide sequence carrying one, or more, epitope(s) characteristic of a protein produced at the sporozoite stage and in hepatocytes infected with P. falciparum, this sequence comprising a succession of 10 amino acids to the maximum number of amino acids of the following peptide arrangement; Glu-Phe-Arg-Val-Ser-Thr-Ser-Asp-Thr-Pro-Gly-Gly-Asn-Glu-Ser-Ser-Ser- Ala-Phe-Pro-Gln-Phe-Ile-Trp-Ser-Ala-Glu-Lys-Lys-Asp-Glu-Lys-Glu-Ala- Ser-Glu-Gln-Gly-Glu-Glu-Ser-His-Lys-Lys-Glu-Asn-Ser-Gln-Glu-Ser-Ala- Asn-Gly-Lys-Asp-Asp-Val-Lys-Glu-Glu-Lys-Lys-Thr-Asn-Glu-Lys-Lys-Asp- Asp-Gly-Lys-Thr-Asp-Lys-Val-Gln-Glu-Lys-Val-Leu-Glu-Lys-Ser-Pro-Lys- Glu-Phe. It also relates to the use of these polypeptides, as well as of the nucleotide sequences coding for these polypeptides, in methods for in vitro diagnosis of malaria on a biological sample originating from the individual in whom the disease is to be detected.
AT90400985T 1989-04-12 1990-04-10 ANTIGEN PROTEIN OF THE SPOROZOITE AND HEPATIC PHASE OF P. FALCIPARUM. ATE120800T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8904847A FR2645877B1 (en) 1989-04-12 1989-04-12 MOLECULES COMPRISING AT LEAST ONE PEPTIDE SEQUENCE CARRYING ONE, OR SEVERAL, CHARACTERISTIC EPITOPE OF A PROTEIN PRODUCED BY P. FALCIPARUM AT THE SPOROZOITE STAGE AND IN THE HEPATOCYTES

Publications (1)

Publication Number Publication Date
ATE120800T1 true ATE120800T1 (en) 1995-04-15

Family

ID=9380650

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90400985T ATE120800T1 (en) 1989-04-12 1990-04-10 ANTIGEN PROTEIN OF THE SPOROZOITE AND HEPATIC PHASE OF P. FALCIPARUM.

Country Status (9)

Country Link
US (2) US5690941A (en)
EP (1) EP0407230B1 (en)
AT (1) ATE120800T1 (en)
AU (1) AU640923B2 (en)
DE (1) DE69018325D1 (en)
FR (1) FR2645877B1 (en)
NZ (1) NZ233328A (en)
PT (1) PT93764B (en)
ZA (1) ZA902831B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672290B1 (en) 1991-02-05 1995-04-21 Pasteur Institut SPECIFIC PEPTIDE SEQUENCES OF THE HEPATIC STAGES OF P. FALCIPARUM CARRIERS OF EPITOPES CAPABLE OF STIMULATING T-LYMPHOCYTES
US6270771B1 (en) 1988-10-06 2001-08-07 Institut Pasteur Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
CA2037151A1 (en) * 1990-03-23 1991-09-24 F. Hoffmann-La Roche Ag Plasmodium sporozoite antigen
FR2697022B1 (en) * 1992-10-19 1994-12-16 Pasteur Institut Plasmodium falciparum antigens capable of inducing protective antibodies with broad spectrum - Application to vaccination.
US20030161840A1 (en) * 1992-10-19 2003-08-28 Institut Pasteur Plasmodium falciparum antigens inducing protective antibodies
FR2744724B1 (en) * 1996-02-14 2002-08-02 Pasteur Institut RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PROTEIN MSP-1 OF A PLASMODIUM INFECTIOUS TO MAN FOR THE PRODUCTION OF ANTI-MALARIA VACCINES
US20030104003A1 (en) * 2001-05-25 2003-06-05 James Anthony A. Novel surface protein of the malaria parasite plasmodium falciparum

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535058A (en) * 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4584268A (en) * 1981-10-13 1986-04-22 Ceriani Roberto Luis Method and compositions for carcinoma diagnosis
US4666845A (en) * 1983-12-16 1987-05-19 Sloan-Kettering Institute Monoclonal antibodies to ovarian, cervical and uterine human cancers and method of diagnosis
US4687734A (en) * 1984-06-07 1987-08-18 Chester Samuel J Immunoassay for the detection of human colon cancer using a polyclonal antibody derived from a capillary culture of tumor cells
US4708930A (en) * 1984-11-09 1987-11-24 Coulter Corporation Monoclonal antibody to a human carcinoma tumor associated antigen
IS1355B6 (en) * 1984-11-12 1989-04-19 Lister Institute Of Preventive Medicine Multicolor explores
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5188967A (en) * 1985-05-02 1993-02-23 Institut Pasteur Agents for the in vitro diagnosis of malignant cells originating in the digestive tract
EP0206849B1 (en) * 1985-05-02 1993-09-29 Institut Pasteur Method for the diagnosis in vitro of malignant cells originating from the digestive duct
US4725538A (en) * 1985-10-25 1988-02-16 The Beth Israel Hospital Association Method of assaying the presence of cancer cells
US5112749A (en) * 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein

Also Published As

Publication number Publication date
NZ233328A (en) 1993-01-27
US6100067A (en) 2000-08-08
FR2645877B1 (en) 1991-07-05
FR2645877A1 (en) 1990-10-19
EP0407230A1 (en) 1991-01-09
AU640923B2 (en) 1993-09-09
DE69018325D1 (en) 1995-05-11
PT93764A (en) 1990-11-20
ZA902831B (en) 1991-02-27
US5690941A (en) 1997-11-25
EP0407230B1 (en) 1995-04-05
AU5315790A (en) 1990-10-18
PT93764B (en) 1996-08-30

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