AU784314B2 - Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials - Google Patents
Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials Download PDFInfo
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- AU784314B2 AU784314B2 AU22617/01A AU2261701A AU784314B2 AU 784314 B2 AU784314 B2 AU 784314B2 AU 22617/01 A AU22617/01 A AU 22617/01A AU 2261701 A AU2261701 A AU 2261701A AU 784314 B2 AU784314 B2 AU 784314B2
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- -1 Piperidinyloxy Chemical group 0.000 title claims description 60
- 230000000844 anti-bacterial effect Effects 0.000 title description 6
- 229940088710 antibiotic agent Drugs 0.000 title description 3
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 48
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 16
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- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
- UIJXHKXIOCDSEB-UHFFFAOYSA-N tert-butyl 3-hydroxypiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(O)C1 UIJXHKXIOCDSEB-UHFFFAOYSA-N 0.000 description 1
- UIYOVVYZPVVUMJ-UHFFFAOYSA-N tert-butyl carbamoyl carbonate Chemical compound CC(C)(C)OC(=O)OC(N)=O UIYOVVYZPVVUMJ-UHFFFAOYSA-N 0.000 description 1
- RUPAXCPQAAOIPB-UHFFFAOYSA-N tert-butyl formate Chemical compound CC(C)(C)OC=O RUPAXCPQAAOIPB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17292399P | 1999-12-21 | 1999-12-21 | |
| US60/172923 | 1999-12-21 | ||
| PCT/US2000/033835 WO2001046164A1 (en) | 1999-12-21 | 2000-12-14 | Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2261701A AU2261701A (en) | 2001-07-03 |
| AU784314B2 true AU784314B2 (en) | 2006-03-09 |
Family
ID=22629768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU22617/01A Ceased AU784314B2 (en) | 1999-12-21 | 2000-12-14 | Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6518285B2 (enExample) |
| EP (1) | EP1246810B1 (enExample) |
| JP (1) | JP2003518106A (enExample) |
| CN (1) | CN1227238C (enExample) |
| AR (1) | AR029420A1 (enExample) |
| AT (1) | ATE326452T1 (enExample) |
| AU (1) | AU784314B2 (enExample) |
| CA (1) | CA2395204C (enExample) |
| CO (1) | CO5280081A1 (enExample) |
| CY (1) | CY1106124T1 (enExample) |
| DE (1) | DE60028085T2 (enExample) |
| DK (1) | DK1246810T3 (enExample) |
| ES (1) | ES2265365T3 (enExample) |
| MX (1) | MXPA02006323A (enExample) |
| MY (1) | MY127677A (enExample) |
| PT (1) | PT1246810E (enExample) |
| WO (1) | WO2001046164A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| WO2003031443A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| US6940748B2 (en) | 2002-05-16 | 2005-09-06 | Micron Technology, Inc. | Stacked 1T-nMTJ MRAM structure |
| AU2003202753A1 (en) * | 2003-02-07 | 2004-08-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| EP1620098B1 (en) | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| AU2004299278C9 (en) | 2003-12-18 | 2013-10-24 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| AR051093A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa desaturasa |
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| JP5209254B2 (ja) * | 2007-08-30 | 2013-06-12 | 日本曹達株式会社 | 置換フェノキシアザビシクロオクタン誘導体の製造方法 |
| CN108785728A (zh) * | 2017-05-05 | 2018-11-13 | 国家纳米科学中心 | 含药物中间体修饰的纳米金的抗菌敷料、其制备方法及应用 |
| CN109503569B (zh) * | 2019-01-03 | 2021-01-15 | 山东大学 | 噻唑类衍生物及其制备方法和应用 |
| TW202315624A (zh) * | 2021-10-12 | 2023-04-16 | 瑞士商赫孚孟拉羅股份公司 | 用於治療細菌感染的磺醯基哌𠯤基化合物 |
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| AU1177300A (en) * | 1998-11-11 | 2000-05-29 | Hokuriku Seiyaku Co. Ltd | Thiocarbamic acid derivatives |
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| ES8506659A1 (es) | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| ZA844265B (en) * | 1983-06-07 | 1986-01-29 | Du Pont | Aminomethyl oxooxazolidinyl benzene derivatives useful as antinbacterial agents |
| US4705799A (en) | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
| CA2119556C (en) | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| ATE233766T1 (de) | 1994-11-15 | 2003-03-15 | Upjohn Co | Antibakterielle bizyklische oxazin und thiazin- oxazolidinone |
| US6124334A (en) | 1995-02-03 | 2000-09-26 | Pharmacia & Upjohn Company | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
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| FI974180A0 (fi) | 1995-05-11 | 1997-11-10 | Upjohn Co | Spirosyklisiä ja bisyklisiä diatsinyyli- ja karbatsinyylioksatsolidinoneja |
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- 2000-12-05 US US09/729,342 patent/US6518285B2/en not_active Expired - Lifetime
- 2000-12-14 EP EP00986365A patent/EP1246810B1/en not_active Expired - Lifetime
- 2000-12-14 WO PCT/US2000/033835 patent/WO2001046164A1/en not_active Ceased
- 2000-12-14 PT PT00986365T patent/PT1246810E/pt unknown
- 2000-12-14 MX MXPA02006323A patent/MXPA02006323A/es active IP Right Grant
- 2000-12-14 ES ES00986365T patent/ES2265365T3/es not_active Expired - Lifetime
- 2000-12-14 CN CNB008189803A patent/CN1227238C/zh not_active Expired - Fee Related
- 2000-12-14 AU AU22617/01A patent/AU784314B2/en not_active Ceased
- 2000-12-14 DE DE60028085T patent/DE60028085T2/de not_active Expired - Fee Related
- 2000-12-14 AT AT00986365T patent/ATE326452T1/de not_active IP Right Cessation
- 2000-12-14 DK DK00986365T patent/DK1246810T3/da active
- 2000-12-14 JP JP2001547075A patent/JP2003518106A/ja active Pending
- 2000-12-14 CA CA002395204A patent/CA2395204C/en not_active Expired - Fee Related
- 2000-12-20 AR ARP000106796A patent/AR029420A1/es unknown
- 2000-12-20 MY MYPI20006020A patent/MY127677A/en unknown
- 2000-12-21 CO CO00097143A patent/CO5280081A1/es not_active Application Discontinuation
-
2006
- 2006-07-21 CY CY20061101016T patent/CY1106124T1/el unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1177300A (en) * | 1998-11-11 | 2000-05-29 | Hokuriku Seiyaku Co. Ltd | Thiocarbamic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| CY1106124T1 (el) | 2011-06-08 |
| JP2003518106A (ja) | 2003-06-03 |
| EP1246810B1 (en) | 2006-05-17 |
| ATE326452T1 (de) | 2006-06-15 |
| AR029420A1 (es) | 2003-06-25 |
| EP1246810A1 (en) | 2002-10-09 |
| DE60028085D1 (de) | 2006-06-22 |
| MXPA02006323A (es) | 2003-09-22 |
| CA2395204C (en) | 2008-02-05 |
| CN1434810A (zh) | 2003-08-06 |
| DE60028085T2 (de) | 2006-12-07 |
| AU2261701A (en) | 2001-07-03 |
| CA2395204A1 (en) | 2001-06-28 |
| CO5280081A1 (es) | 2003-05-30 |
| US20020103377A1 (en) | 2002-08-01 |
| WO2001046164A1 (en) | 2001-06-28 |
| CN1227238C (zh) | 2005-11-16 |
| ES2265365T3 (es) | 2007-02-16 |
| MY127677A (en) | 2006-12-29 |
| DK1246810T3 (da) | 2006-09-18 |
| PT1246810E (pt) | 2006-08-31 |
| US6518285B2 (en) | 2003-02-11 |
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