AU781805B2 - Inhibitors of the lectin complement pathway (LCP) and their use - Google Patents
Inhibitors of the lectin complement pathway (LCP) and their use Download PDFInfo
- Publication number
- AU781805B2 AU781805B2 AU66370/00A AU6637000A AU781805B2 AU 781805 B2 AU781805 B2 AU 781805B2 AU 66370/00 A AU66370/00 A AU 66370/00A AU 6637000 A AU6637000 A AU 6637000A AU 781805 B2 AU781805 B2 AU 781805B2
- Authority
- AU
- Australia
- Prior art keywords
- mbl
- receptor antagonist
- complement activation
- mbl receptor
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14881599P | 1999-08-13 | 1999-08-13 | |
US60/148815 | 1999-08-13 | ||
PCT/US2000/022123 WO2001012212A1 (fr) | 1999-08-13 | 2000-08-14 | Inhibiteurs de la voie du complement a lectine (lpc) et utilisation de ceux-ci |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6637000A AU6637000A (en) | 2001-03-13 |
AU781805B2 true AU781805B2 (en) | 2005-06-16 |
Family
ID=22527516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU66370/00A Ceased AU781805B2 (en) | 1999-08-13 | 2000-08-14 | Inhibitors of the lectin complement pathway (LCP) and their use |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1204419A1 (fr) |
JP (1) | JP2003507338A (fr) |
AU (1) | AU781805B2 (fr) |
CA (1) | CA2380979A1 (fr) |
WO (1) | WO2001012212A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7083786B2 (en) | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
US7273925B1 (en) | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
US7112414B2 (en) | 2000-07-13 | 2006-09-26 | Jens Christian Jensenius | Masp-2, a complement-fixing enzyme, and uses for it |
DE10130985B4 (de) * | 2001-06-27 | 2004-03-18 | B.R.A.H.M.S Ag | Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente |
CN101897969B (zh) | 2003-02-21 | 2014-04-02 | 健泰科生物技术公司 | 补体抑制剂在制备用于预防或抑制组织损伤的药物中的用途 |
SI2374819T1 (sl) | 2003-05-12 | 2017-09-29 | Helion Biotech Aps | Protitelesa proteina MASP-2 |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
GB0412966D0 (en) | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
WO2006131874A2 (fr) * | 2005-06-06 | 2006-12-14 | Univ Cape Town | Procedes de traitement ou de prophylaxie de l'atherosclerose et d'une lesion de reperfusion |
US8524453B2 (en) | 2006-02-10 | 2013-09-03 | The Brigham And Woman's Hospital, Inc. | Lectin complement pathway assays and related compositions and methods |
US20110293524A1 (en) * | 2008-02-29 | 2011-12-01 | The Brigham and Women"s Hosptial Inc. | Methods and compositions for the regulation of lectin complement pathway (lcp)-associated complement activation in hyperglycemic myocardial damage |
CN106390117A (zh) | 2009-10-16 | 2017-02-15 | 奥默罗斯公司 | 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法 |
GEP20247583B (en) * | 2015-11-09 | 2024-01-10 | Univ Leicester | Methods for treating condi tions associated with masp-2 dependent complement activation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9500023L (sv) * | 1994-05-17 | 1995-11-18 | Beki Ab | Sätt att detektera cancer |
DE19806185C2 (de) * | 1998-02-02 | 1999-11-18 | Biogenes Gmbh | Immunoassay und Testkit zur Bestimmung von fucosyliertem Protein in einer biologischen Probe |
EP1140171A4 (fr) * | 1998-12-15 | 2002-03-13 | Brigham & Womens Hospital | Techniques et produits permettant de reguler l'activation du complement associee a la voie du complement a lectine |
-
2000
- 2000-08-14 AU AU66370/00A patent/AU781805B2/en not_active Ceased
- 2000-08-14 WO PCT/US2000/022123 patent/WO2001012212A1/fr active IP Right Grant
- 2000-08-14 EP EP00954011A patent/EP1204419A1/fr not_active Withdrawn
- 2000-08-14 CA CA002380979A patent/CA2380979A1/fr not_active Abandoned
- 2000-08-14 JP JP2001516557A patent/JP2003507338A/ja not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
COLLARD C.D ET AL, FASEB JOURNAL (1998) VOL 12 (4) PP A29 * |
COLLARD C.D ET AL, MOLECULAR IMM. (1999) VOL 36 (4-5) P 278 * |
Also Published As
Publication number | Publication date |
---|---|
EP1204419A1 (fr) | 2002-05-15 |
JP2003507338A (ja) | 2003-02-25 |
AU6637000A (en) | 2001-03-13 |
CA2380979A1 (fr) | 2001-02-22 |
WO2001012212A1 (fr) | 2001-02-22 |
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