AU781122B2 - Cartridge for conducting a chemical reaction - Google Patents
Cartridge for conducting a chemical reaction Download PDFInfo
- Publication number
- AU781122B2 AU781122B2 AU53009/00A AU5300900A AU781122B2 AU 781122 B2 AU781122 B2 AU 781122B2 AU 53009/00 A AU53009/00 A AU 53009/00A AU 5300900 A AU5300900 A AU 5300900A AU 781122 B2 AU781122 B2 AU 781122B2
- Authority
- AU
- Australia
- Prior art keywords
- chamber
- cartridge
- vessel
- reaction chamber
- cartridge according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13670399P | 1999-05-28 | 1999-05-28 | |
| US60/136703 | 1999-05-28 | ||
| US09/469,724 US6431476B1 (en) | 1999-12-21 | 1999-12-21 | Apparatus and method for rapid ultrasonic disruption of cells or viruses |
| US09/469724 | 1999-12-21 | ||
| PCT/US2000/014739 WO2000072970A1 (en) | 1999-05-28 | 2000-05-30 | Cartridge for conducting a chemical reaction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5300900A AU5300900A (en) | 2000-12-18 |
| AU781122B2 true AU781122B2 (en) | 2005-05-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU53009/00A Expired AU781122B2 (en) | 1999-05-28 | 2000-05-30 | Cartridge for conducting a chemical reaction |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1181098B2 (enExample) |
| JP (2) | JP4495866B2 (enExample) |
| AT (1) | ATE333938T1 (enExample) |
| AU (1) | AU781122B2 (enExample) |
| CA (1) | CA2373198C (enExample) |
| DE (1) | DE60029582T3 (enExample) |
| DK (1) | DK1181098T4 (enExample) |
| ES (1) | ES2272289T5 (enExample) |
| WO (1) | WO2000072970A1 (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US8048386B2 (en) | 2002-02-25 | 2011-11-01 | Cepheid | Fluid processing and control |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US6811695B2 (en) | 2001-06-07 | 2004-11-02 | Nanostream, Inc. | Microfluidic filter |
| US6919046B2 (en) | 2001-06-07 | 2005-07-19 | Nanostream, Inc. | Microfluidic analytical devices and methods |
| ATE457199T1 (de) | 2001-12-14 | 2010-02-15 | Arkray Inc | Probenmessvorrichtung |
| US20030198576A1 (en) * | 2002-02-22 | 2003-10-23 | Nanostream, Inc. | Ratiometric dilution devices and methods |
| JP4106977B2 (ja) | 2002-06-21 | 2008-06-25 | 株式会社日立製作所 | 分析チップ及び分析装置 |
| US6936167B2 (en) | 2002-10-31 | 2005-08-30 | Nanostream, Inc. | System and method for performing multiple parallel chromatographic separations |
| AU2003287449A1 (en) | 2002-10-31 | 2004-05-25 | Nanostream, Inc. | Parallel detection chromatography systems |
| US7010964B2 (en) | 2002-10-31 | 2006-03-14 | Nanostream, Inc. | Pressurized microfluidic devices with optical detection regions |
| US6987263B2 (en) | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
| CA3171720C (en) | 2002-12-26 | 2024-01-09 | Meso Scale Technologies, Llc. | Methods for conducting electrochemiluminescence measurements |
| US7445926B2 (en) | 2002-12-30 | 2008-11-04 | The Regents Of The University Of California | Fluid control structures in microfluidic devices |
| US7074327B2 (en) | 2003-05-08 | 2006-07-11 | Nanostream, Inc. | Sample preparation for parallel chromatography |
| WO2005011867A2 (en) | 2003-07-31 | 2005-02-10 | Handylab, Inc. | Processing particle-containing samples |
| US7028536B2 (en) | 2004-06-29 | 2006-04-18 | Nanostream, Inc. | Sealing interface for microfluidic device |
| US7032605B1 (en) | 2003-10-15 | 2006-04-25 | Douglas B. Dority | Dual piston rotary valve |
| WO2005055804A2 (en) | 2003-12-02 | 2005-06-23 | Musc Foundation For Research Development | Methods and compositions for diagnosing epithelial cell cancer |
| GB2416030B (en) * | 2004-01-28 | 2008-07-23 | Norchip As | A diagnostic system for carrying out a nucleic acid sequence amplification and detection process |
| US7981616B2 (en) | 2004-02-27 | 2011-07-19 | Musc Foundation For Research Development | Enhanced detection of RNA using a panel of truncated gene-specific primers for reverse transcription |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| CA2565572C (en) | 2004-05-03 | 2018-03-06 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples |
| AU2005271961B8 (en) | 2004-07-09 | 2011-11-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of markers in esophageal cancer, colon cancer, head and neck cancer and melanoma |
| WO2006013926A1 (ja) * | 2004-08-05 | 2006-02-09 | Universal Bio Research Co., Ltd. | 反応容器、反応容器液導入装置、液導入反応測定装置、および液導入装置 |
| EP1801196A4 (en) * | 2004-10-06 | 2011-06-15 | Universal Bio Research Co Ltd | REACTION TANK AND REACTION CONTROL MODULE |
| CA2610294C (en) * | 2005-05-09 | 2023-10-03 | Theranos, Inc. | Point-of-care fluidic systems and uses thereof |
| TW200714898A (en) * | 2005-08-02 | 2007-04-16 | 3M Innovative Properties Co | Apparatus and method for detecting an analyte |
| US20070184547A1 (en) * | 2005-10-11 | 2007-08-09 | Kalyan Handique | Polynucleotide sample preparation device |
| ES2587007T3 (es) | 2006-03-24 | 2016-10-20 | Handylab, Inc. | Sistema integrado para procesar muestras microfluídicas, y métodos de uso del mismo |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| WO2007122785A1 (ja) * | 2006-04-18 | 2007-11-01 | Ngk Insulators, Ltd. | 反応装置、該反応装置用反応モジュール及び該反応装置用送液装置 |
| JPWO2007122785A1 (ja) * | 2006-04-18 | 2009-08-27 | 日本碍子株式会社 | 反応装置、該反応装置用反応モジュール及び該反応装置用送液装置 |
| EP2021128A2 (en) * | 2006-05-01 | 2009-02-11 | Koninklijke Philips Electronics N.V. | Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample |
| FR2901360A1 (fr) * | 2006-05-16 | 2007-11-23 | Horiba Abx Sas Soc Par Actions | Dispositif de conditionnement pour analyse biologique |
| US8119352B2 (en) | 2006-06-20 | 2012-02-21 | Cepheld | Multi-stage amplification reactions by control of sequence replication times |
| US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
| EP2091647A2 (en) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| JP5097428B2 (ja) * | 2007-04-03 | 2012-12-12 | 東洋製罐株式会社 | 検査用容器 |
| EP2145949A4 (en) | 2007-04-06 | 2013-07-03 | Universal Bio Research Co Ltd | DEVICE AND METHOD FOR CONTROLLING TEMPERATURE |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| JP2009240296A (ja) * | 2007-12-14 | 2009-10-22 | Ngk Insulators Ltd | 流体収容カートリッジ及びその利用 |
| US8961902B2 (en) | 2008-04-23 | 2015-02-24 | Bioscale, Inc. | Method and apparatus for analyte processing |
| JP2010099061A (ja) * | 2008-09-26 | 2010-05-06 | Sekisui Chem Co Ltd | 検出用カートリッジ及び被検出物質の検出方法 |
| US20100221726A1 (en) | 2009-02-09 | 2010-09-02 | Frederic Zenhausern | Relating to devices |
| RU2549443C2 (ru) | 2009-04-14 | 2015-04-27 | Биокартис Нв | Индуцированная высокоинтенсивным фокусированным ультразвуком кавитация с уменьшенным порогом мощности |
| RU2522350C2 (ru) | 2009-04-15 | 2014-07-10 | Биокартис Са | Защита биоаналитических камер для пробы |
| ES2822105T3 (es) | 2009-04-15 | 2021-04-29 | Biocartis Nv | Sistema de detección óptica para monitorizar la reacción rtPCR |
| JP5766180B2 (ja) | 2009-05-06 | 2015-08-19 | ビオカルティ ナームローゼ フェノーツハップBiocartis NV | 試料キャリヤを切断するための装置 |
| US20110130560A1 (en) * | 2009-05-29 | 2011-06-02 | Bio-Rad Laboratories, Inc. | Sonication cartridge for nucleic acid extraction |
| EP2333105A1 (en) | 2009-12-08 | 2011-06-15 | Koninklijke Philips Electronics N.V. | Selective lysis of cells |
| KR101643196B1 (ko) * | 2010-02-23 | 2016-07-27 | 루미넥스 코포레이션 | 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법 |
| CA3016653C (en) * | 2010-04-16 | 2024-01-02 | Opko Diagnostics, Llc | Feedback control in microfluidic systems |
| ES2617599T3 (es) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración |
| CA2831969A1 (en) * | 2011-06-06 | 2012-12-30 | Biocartis S.A. | Selective lysis of cells by ionic surfactants |
| RU2622432C2 (ru) | 2011-09-30 | 2017-06-15 | Бектон, Дикинсон Энд Компани | Унифицированная полоска для реактивов |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
| JP6262152B2 (ja) | 2012-02-03 | 2018-01-17 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 分子診断試験の分布及び試験間のコンパチビリティ判断のための外部ファイル |
| EP3381558A1 (en) | 2012-03-16 | 2018-10-03 | Stat-Diagnostica & Innovation, S.L. | A method for a test cartridge with integrated transfer module |
| EA031833B1 (ru) | 2012-04-27 | 2019-02-28 | Цефеид | Устройство с разнообразными обрабатывающими модулями |
| US9075042B2 (en) * | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| EP2970848B1 (en) * | 2013-03-15 | 2018-10-17 | Cepheid | Multi-chambered lid apparatus |
| JP6231295B2 (ja) * | 2013-05-13 | 2017-11-15 | 東京理化器械株式会社 | 反応装置 |
| GB2516666B (en) * | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | Fluidic cartridge for nucleic acid amplification and detection |
| EP2878375A1 (en) * | 2013-11-29 | 2015-06-03 | Genewave | Microfluidic cartridge for molecular diagnosis, docking station using such a microfluidic cartridge, and process for analyzing a biological sample |
| CN204727866U (zh) * | 2014-03-31 | 2015-10-28 | 博奥生物集团有限公司 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
| AU2015267189B2 (en) * | 2014-05-27 | 2019-12-05 | Illumina, Inc. | Systems and methods for biochemical analysis including a base instrument and a removable cartridge |
| JP6976167B2 (ja) | 2014-06-13 | 2021-12-08 | キュー−リネア エービー | 微生物の検出及び特徴付け方法 |
| AT516421B1 (de) * | 2014-10-31 | 2016-07-15 | Anton Paar Gmbh | Verfahren und Messgerät zur Dichtemessung von fluiden Medien |
| JP6412435B2 (ja) * | 2015-02-06 | 2018-10-24 | 信越ポリマー株式会社 | マイクロ流路チップ |
| GB201507026D0 (en) | 2015-04-24 | 2015-06-10 | Linea Ab Q | Medical sample transportation container |
| JP6714603B2 (ja) | 2015-10-09 | 2020-07-01 | シスメックス株式会社 | 検体処理チップ、検体処理装置および検体処理方法 |
| GB2554767A (en) | 2016-04-21 | 2018-04-11 | Q Linea Ab | Detecting and characterising a microorganism |
| WO2019006436A1 (en) * | 2017-06-30 | 2019-01-03 | Inscripta, Inc. | METHODS, MODULES, INSTRUMENTS AND SYSTEMS FOR AUTOMATED CELL PROCESSING |
| CA3090877A1 (en) * | 2018-02-12 | 2019-08-15 | Corning Incorporated | Remote monitoring system for cell culture |
| EP3593903B1 (en) | 2018-07-10 | 2020-09-02 | Sartorius Stedim Biotech GmbH | Liquid filtering system with vacuum valve |
| CN108871512B (zh) * | 2018-07-20 | 2024-02-27 | 宁波恒帅股份有限公司 | 一种液位传感器的检测装置 |
| CN109046477B (zh) * | 2018-07-23 | 2023-12-19 | 深圳市呈晖医疗科技有限公司 | 离心微流控装置 |
| US11745177B2 (en) | 2019-01-10 | 2023-09-05 | Instrumentation Laboratory Company | Ultrasound lysing of whole blood |
| KR101990793B1 (ko) * | 2019-01-17 | 2019-06-19 | 대한민국 | 수산물양식을 위한 스마트 수질측정시스템 |
| WO2020154601A1 (en) * | 2019-01-24 | 2020-07-30 | Nirrin Technologies, Inc. | Flow cell device, system and method for optical interrogation using the flow cell device |
| WO2020159992A1 (en) | 2019-01-29 | 2020-08-06 | Instrumentation Laboratory Company | Hematocrit level detection using ir laser refraction |
| AU2020248704B2 (en) | 2019-03-22 | 2023-02-16 | Siemens Healthcare Diagnostics Inc. | Biological sample analyzer with accelerated thermal warming |
| CA3134430A1 (en) * | 2019-03-22 | 2020-10-01 | Siemens Healthcare Diagnostics Inc. | Biological sample analyzer with forced air convection plenum |
| US11964279B2 (en) | 2019-07-15 | 2024-04-23 | Lexagene, Inc. | Sample preparation cartridges and apparatuses |
| US12226767B2 (en) | 2019-09-18 | 2025-02-18 | Illumina, Inc. | Systems and related sample loading manifold assemblies |
| US12054320B2 (en) | 2019-09-23 | 2024-08-06 | Cepheid | Multi-chambered lid apparatus with reagent port |
| PL3930903T3 (pl) * | 2019-12-10 | 2023-12-27 | Illumina Singapore Pte Ltd | Systemy uruchamiania i sposoby użycia z wykorzystaniem kuwet przepływowych |
| WO2021183333A1 (en) * | 2020-03-12 | 2021-09-16 | Lexagene, Inc. | Sample cartridges |
| KR20230093054A (ko) | 2020-10-30 | 2023-06-26 | 세페이드 | 교체 가능한 처리 모듈 및 원격 모니터링을 갖는 진단 분석 시스템 |
| CN116457097A (zh) | 2020-12-01 | 2023-07-18 | 伊鲁米那有限公司 | 井凹组件和相关方法 |
| CN115725403B (zh) * | 2021-08-27 | 2025-12-09 | 广州万孚生物技术股份有限公司 | 体外分析诊断检测装置及pcr模组 |
| CN115825404B (zh) * | 2022-12-12 | 2025-05-09 | 中国人民解放军陆军勤务学院 | 一种废旧油品回收在线检测桶及其检测方法 |
| WO2025120718A1 (ja) * | 2023-12-05 | 2025-06-12 | 株式会社日立ハイテク | バルブ開閉システム、および分析システム |
| CN118209719B (zh) * | 2024-03-27 | 2025-12-05 | 集美大学 | 一种集成毛发预处理的微流控毒品检测装置 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5133937A (en) * | 1989-06-01 | 1992-07-28 | Iniziative Marittime, 1991 S.R.L. | Analysis system having a removable reaction cartridge and temperature control |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0318256B1 (en) * | 1987-11-23 | 1992-12-23 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Cuvette with non-flexing thermally conductive wall |
| US4902624A (en) † | 1987-11-23 | 1990-02-20 | Eastman Kodak Company | Temperature cycling cuvette |
| CA1338505C (en) * | 1989-02-03 | 1996-08-06 | John Bruce Findlay | Containment cuvette for pcr and method of use |
| US5229297A (en) † | 1989-02-03 | 1993-07-20 | Eastman Kodak Company | Containment cuvette for PCR and method of use |
| JPH03223674A (ja) * | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | 反応容器 |
| DE69303898T3 (de) * | 1992-05-01 | 2007-01-18 | Trustees Of The University Of Pennsylvania | Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen |
| JPH08506664A (ja) * | 1993-02-01 | 1996-07-16 | セック,リミテッド | Dna配列決定の方法および装置 |
| DE4420732A1 (de) * | 1994-06-15 | 1995-12-21 | Boehringer Mannheim Gmbh | Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe |
| FR2749663B1 (fr) * | 1996-06-07 | 1998-07-31 | Bio Merieux | Carte d'analyse a usage unique comprenant un conduit d'ecoul ement de liquides |
| EP2333520B1 (en) * | 1997-02-28 | 2014-06-25 | Cepheid | Heat exchanging, optically interrogated chemical reaction assembly |
| US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
| WO1998057145A1 (en) * | 1997-06-10 | 1998-12-17 | Quadrivium, L.L.C. | System and method for detection of a biological condition |
| AU745989B2 (en) * | 1997-08-13 | 2002-04-11 | Cepheid | Microstructures for the manipulation of fluid samples |
| JP4041560B2 (ja) * | 1997-09-09 | 2008-01-30 | 株式会社テクノメデイカ | 検査液分析装置用使い捨て成分検出具及び前記成分検査具に対する検査液供給方法 |
-
2000
- 2000-05-30 EP EP00937894A patent/EP1181098B2/en not_active Expired - Lifetime
- 2000-05-30 DK DK00937894.4T patent/DK1181098T4/da active
- 2000-05-30 CA CA2373198A patent/CA2373198C/en not_active Expired - Lifetime
- 2000-05-30 ES ES00937894T patent/ES2272289T5/es not_active Expired - Lifetime
- 2000-05-30 DE DE60029582T patent/DE60029582T3/de not_active Expired - Lifetime
- 2000-05-30 WO PCT/US2000/014739 patent/WO2000072970A1/en not_active Ceased
- 2000-05-30 AU AU53009/00A patent/AU781122B2/en not_active Expired
- 2000-05-30 AT AT00937894T patent/ATE333938T1/de active
- 2000-05-30 JP JP2000621073A patent/JP4495866B2/ja not_active Expired - Lifetime
-
2009
- 2009-08-03 JP JP2009180791A patent/JP4800412B2/ja not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5133937A (en) * | 1989-06-01 | 1992-07-28 | Iniziative Marittime, 1991 S.R.L. | Analysis system having a removable reaction cartridge and temperature control |
Also Published As
| Publication number | Publication date |
|---|---|
| DK1181098T4 (da) | 2011-09-26 |
| AU5300900A (en) | 2000-12-18 |
| DE60029582T2 (de) | 2007-07-12 |
| EP1181098B2 (en) | 2011-07-06 |
| DK1181098T3 (da) | 2006-12-27 |
| JP4495866B2 (ja) | 2010-07-07 |
| ES2272289T3 (es) | 2007-05-01 |
| EP1181098B1 (en) | 2006-07-26 |
| ES2272289T5 (es) | 2011-10-21 |
| DE60029582D1 (de) | 2006-09-07 |
| JP2009282041A (ja) | 2009-12-03 |
| JP2003500674A (ja) | 2003-01-07 |
| DE60029582T3 (de) | 2012-03-08 |
| EP1181098A1 (en) | 2002-02-27 |
| WO2000072970A1 (en) | 2000-12-07 |
| CA2373198C (en) | 2011-10-11 |
| JP4800412B2 (ja) | 2011-10-26 |
| ATE333938T1 (de) | 2006-08-15 |
| CA2373198A1 (en) | 2000-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |