AU7810994A - Process for producing a virus-inactivated factor viii-containing fraction by chromatographic methods - Google Patents
Process for producing a virus-inactivated factor viii-containing fraction by chromatographic methodsInfo
- Publication number
- AU7810994A AU7810994A AU78109/94A AU7810994A AU7810994A AU 7810994 A AU7810994 A AU 7810994A AU 78109/94 A AU78109/94 A AU 78109/94A AU 7810994 A AU7810994 A AU 7810994A AU 7810994 A AU7810994 A AU 7810994A
- Authority
- AU
- Australia
- Prior art keywords
- virus
- producing
- factor viii
- chromatographic methods
- containing fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A process for producing a virus-inactivated, factor VIII-containing fraction by chromatographic methods in which, starting with cryoprecipitate or blood plasma, possibly followed by a treatment with aluminium hydroxide, at least one separating operation is performed by membrane chromatography after the dissolution of the cryoprecipitate. The fractions are subjected to virus inactivation and preferably an additional pasteurisation step.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4337573 | 1993-11-04 | ||
DE4337573A DE4337573C1 (en) | 1993-11-04 | 1993-11-04 | Process for the preparation of a virus-inactivated factor VIII-containing fraction by means of chromatographic methods |
PCT/EP1994/003258 WO1995012609A1 (en) | 1993-11-04 | 1994-09-30 | Process for producing a virus-inactivated factor viii-containing fraction by chromatographic methods |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7810994A true AU7810994A (en) | 1995-05-23 |
AU687451B2 AU687451B2 (en) | 1998-02-26 |
Family
ID=6501733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU78109/94A Expired AU687451B2 (en) | 1993-11-04 | 1994-09-30 | Process for producing a virus-inactivated factor VIII-containing fraction by chromatographic methods |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0726907B1 (en) |
JP (1) | JP3739788B2 (en) |
KR (1) | KR960705841A (en) |
CN (1) | CN1109045C (en) |
AT (1) | ATE228533T1 (en) |
AU (1) | AU687451B2 (en) |
CA (1) | CA2175670C (en) |
CZ (1) | CZ290186B6 (en) |
DE (2) | DE4337573C1 (en) |
ES (1) | ES2182846T3 (en) |
FI (1) | FI116569B (en) |
HU (1) | HU222087B1 (en) |
IL (1) | IL111263A (en) |
MY (1) | MY113294A (en) |
NO (1) | NO317112B1 (en) |
PL (1) | PL181725B1 (en) |
RU (1) | RU2148411C1 (en) |
SK (1) | SK284215B6 (en) |
UA (1) | UA43855C2 (en) |
WO (1) | WO1995012609A1 (en) |
ZA (1) | ZA948667B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19618851C1 (en) * | 1996-05-10 | 1997-07-24 | Octapharma Ag | Testing factor VIII containing preparations |
EP0885394B1 (en) * | 1996-03-08 | 2000-08-16 | Octapharma AG | Process for testing suitability of protein fractions containing factor viii |
ES2137878B1 (en) * | 1997-12-01 | 2000-10-01 | Grifols Grupo Sa | PROCEDURE FOR OBTAINING AN ATTENUATED HUMAN PLASMA OF VIRUSES FOR THERAPEUTIC USE. |
WO2009156430A1 (en) * | 2008-06-24 | 2009-12-30 | Octapharma Ag | A process of purifying coagulation factor viii |
CA2821711C (en) | 2010-12-15 | 2017-10-10 | Baxter International Inc. | Eluate collection using conductivity gradient |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
DE3432083A1 (en) * | 1984-08-31 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | PASTEURIZED, ISOAGGLUTININ-FREE FACTOR VIII PREPARATION AND METHOD FOR THE PRODUCTION THEREOF |
US5043428A (en) * | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
JPS62191042A (en) * | 1986-02-17 | 1987-08-21 | Kanegafuchi Chem Ind Co Ltd | Blood coagulation factor viii adsorbent and method for purifying blood coagulation factor viii using same |
CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
US4795806A (en) * | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
CA2001720C (en) * | 1988-10-31 | 2001-10-02 | Randal A. Goffe | Membrane affinity apparatus and purification methods related thereto |
ATE85221T1 (en) * | 1988-11-05 | 1993-02-15 | Octapharma Ag | PROCESS FOR THE PREPARATION OF A HIGH PURITY, NON-INFECTIOUS ANTIHAEMOPHILIA FACTOR USING CHROMATOGRAPHY. |
CH678155A5 (en) * | 1989-08-09 | 1991-08-15 | Fischer Ag Georg | |
AT399818B (en) * | 1992-04-24 | 1995-07-25 | Immuno Ag | METHOD FOR PRODUCING A HIGH PURIFIED VIRUS-SAFE FACTOR VIII PREPARATION |
-
1993
- 1993-11-04 DE DE4337573A patent/DE4337573C1/en not_active Revoked
-
1994
- 1994-09-30 JP JP51297795A patent/JP3739788B2/en not_active Expired - Fee Related
- 1994-09-30 CN CN94194020A patent/CN1109045C/en not_active Expired - Fee Related
- 1994-09-30 SK SK566-96A patent/SK284215B6/en not_active IP Right Cessation
- 1994-09-30 AT AT94928846T patent/ATE228533T1/en active
- 1994-09-30 CZ CZ19961187A patent/CZ290186B6/en not_active IP Right Cessation
- 1994-09-30 DE DE59410213T patent/DE59410213D1/en not_active Expired - Lifetime
- 1994-09-30 AU AU78109/94A patent/AU687451B2/en not_active Expired
- 1994-09-30 EP EP94928846A patent/EP0726907B1/en not_active Expired - Lifetime
- 1994-09-30 HU HU9601192A patent/HU222087B1/en not_active IP Right Cessation
- 1994-09-30 ES ES94928846T patent/ES2182846T3/en not_active Expired - Lifetime
- 1994-09-30 KR KR1019960702337A patent/KR960705841A/en not_active Application Discontinuation
- 1994-09-30 RU RU96110890A patent/RU2148411C1/en not_active IP Right Cessation
- 1994-09-30 PL PL94314185A patent/PL181725B1/en not_active IP Right Cessation
- 1994-09-30 WO PCT/EP1994/003258 patent/WO1995012609A1/en active IP Right Grant
- 1994-09-30 CA CA002175670A patent/CA2175670C/en not_active Expired - Fee Related
- 1994-09-30 UA UA96041756A patent/UA43855C2/en unknown
- 1994-10-12 IL IL11126394A patent/IL111263A/en not_active IP Right Cessation
- 1994-11-03 ZA ZA948667A patent/ZA948667B/en unknown
- 1994-11-03 MY MYPI94002921A patent/MY113294A/en unknown
-
1996
- 1996-05-03 NO NO19961816A patent/NO317112B1/en not_active IP Right Cessation
- 1996-05-03 FI FI961900A patent/FI116569B/en active IP Right Grant
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