AU687451B2 - Process for producing a virus-inactivated factor VIII-containing fraction by chromatographic methods - Google Patents

Process for producing a virus-inactivated factor VIII-containing fraction by chromatographic methods

Info

Publication number
AU687451B2
AU687451B2 AU78109/94A AU7810994A AU687451B2 AU 687451 B2 AU687451 B2 AU 687451B2 AU 78109/94 A AU78109/94 A AU 78109/94A AU 7810994 A AU7810994 A AU 7810994A AU 687451 B2 AU687451 B2 AU 687451B2
Authority
AU
Australia
Prior art keywords
virus
producing
factor viii
chromatographic methods
containing fraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU78109/94A
Other versions
AU7810994A (en
Inventor
Djuro Josic
Monika Andrea Stadler
Ales Strancar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Octapharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6501733&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU687451(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma AG filed Critical Octapharma AG
Publication of AU7810994A publication Critical patent/AU7810994A/en
Application granted granted Critical
Publication of AU687451B2 publication Critical patent/AU687451B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A process for producing a virus-inactivated, factor VIII-containing fraction by chromatographic methods in which, starting with cryoprecipitate or blood plasma, possibly followed by a treatment with aluminium hydroxide, at least one separating operation is performed by membrane chromatography after the dissolution of the cryoprecipitate. The fractions are subjected to virus inactivation and preferably an additional pasteurisation step.
AU78109/94A 1993-11-04 1994-09-30 Process for producing a virus-inactivated factor VIII-containing fraction by chromatographic methods Expired AU687451B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4337573A DE4337573C1 (en) 1993-11-04 1993-11-04 Process for the preparation of a virus-inactivated factor VIII-containing fraction by means of chromatographic methods
DE4337573 1993-11-04
PCT/EP1994/003258 WO1995012609A1 (en) 1993-11-04 1994-09-30 Process for producing a virus-inactivated factor viii-containing fraction by chromatographic methods

Publications (2)

Publication Number Publication Date
AU7810994A AU7810994A (en) 1995-05-23
AU687451B2 true AU687451B2 (en) 1998-02-26

Family

ID=6501733

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78109/94A Expired AU687451B2 (en) 1993-11-04 1994-09-30 Process for producing a virus-inactivated factor VIII-containing fraction by chromatographic methods

Country Status (21)

Country Link
EP (1) EP0726907B1 (en)
JP (1) JP3739788B2 (en)
KR (1) KR960705841A (en)
CN (1) CN1109045C (en)
AT (1) ATE228533T1 (en)
AU (1) AU687451B2 (en)
CA (1) CA2175670C (en)
CZ (1) CZ290186B6 (en)
DE (2) DE4337573C1 (en)
ES (1) ES2182846T3 (en)
FI (1) FI116569B (en)
HU (1) HU222087B1 (en)
IL (1) IL111263A (en)
MY (1) MY113294A (en)
NO (1) NO317112B1 (en)
PL (1) PL181725B1 (en)
RU (1) RU2148411C1 (en)
SK (1) SK284215B6 (en)
UA (1) UA43855C2 (en)
WO (1) WO1995012609A1 (en)
ZA (1) ZA948667B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156430A1 (en) * 2008-06-24 2009-12-30 Octapharma Ag A process of purifying coagulation factor viii

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1725297A (en) * 1996-03-08 1997-09-22 Octapharma Ag Process for testing suitability of protein fractions containing factor viii
DE19618851C1 (en) * 1996-05-10 1997-07-24 Octapharma Ag Testing factor VIII containing preparations
ES2137878B1 (en) * 1997-12-01 2000-10-01 Grifols Grupo Sa PROCEDURE FOR OBTAINING AN ATTENUATED HUMAN PLASMA OF VIRUSES FOR THERAPEUTIC USE.
RU2253475C1 (en) * 2004-02-02 2005-06-10 Общество с ограниченной ответственностью "Гемоцентр" Method of preparing factor viii preparation
RU2324495C1 (en) * 2006-08-31 2008-05-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Method of making preparation of human blood coagulaton factor viii
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0286323A2 (en) * 1987-03-31 1988-10-12 BAXTER INTERNATIONAL INC. (a Delaware corporation) An ultrapurification process for factor VIII:C
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
AU3687593A (en) * 1992-04-24 1993-10-28 Immuno Aktiengesellschaft A method of producing a factor VIII preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
DE3432083A1 (en) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg PASTEURIZED, ISOAGGLUTININ-FREE FACTOR VIII PREPARATION AND METHOD FOR THE PRODUCTION THEREOF
JPS62191042A (en) * 1986-02-17 1987-08-21 Kanegafuchi Chem Ind Co Ltd Blood coagulation factor viii adsorbent and method for purifying blood coagulation factor viii using same
US4774323A (en) * 1987-06-29 1988-09-27 Rorer Pharmaceutical Corporation Purification of von Willebrand Factor solutions using gel permeation chromatography
US4795806A (en) * 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
CA2001720C (en) * 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
DE3878245D1 (en) * 1988-11-05 1993-03-18 Octapharma Ag METHOD FOR PRODUCING A HIGHLY PURE, NON-INFECTIOUS ANTIHAEMOPHILIE ACTUATOR BY CHROMATOGRAPHY.
CH678155A5 (en) * 1989-08-09 1991-08-15 Fischer Ag Georg

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
EP0286323A2 (en) * 1987-03-31 1988-10-12 BAXTER INTERNATIONAL INC. (a Delaware corporation) An ultrapurification process for factor VIII:C
AU3687593A (en) * 1992-04-24 1993-10-28 Immuno Aktiengesellschaft A method of producing a factor VIII preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009156430A1 (en) * 2008-06-24 2009-12-30 Octapharma Ag A process of purifying coagulation factor viii
US8329871B2 (en) 2008-06-24 2012-12-11 Octapharma Ag Process of purifying coagulation factor VIII
EP2537862A1 (en) * 2008-06-24 2012-12-26 Octapharma AG A process of purifying coagulation factor VIII

Also Published As

Publication number Publication date
MY113294A (en) 2002-01-31
IL111263A0 (en) 1994-12-29
CA2175670A1 (en) 1995-05-11
NO961816D0 (en) 1996-05-03
NO317112B1 (en) 2004-08-16
KR960705841A (en) 1996-11-08
FI116569B (en) 2005-12-30
NO961816L (en) 1996-05-03
DE4337573C1 (en) 1995-05-18
ES2182846T3 (en) 2003-03-16
CZ290186B6 (en) 2002-06-12
JPH09504532A (en) 1997-05-06
CZ118796A3 (en) 1996-12-11
PL181725B1 (en) 2001-09-28
CN1109045C (en) 2003-05-21
ZA948667B (en) 1995-07-07
WO1995012609A1 (en) 1995-05-11
IL111263A (en) 2000-07-16
CA2175670C (en) 2005-08-02
FI961900L (en) 1996-05-03
HU222087B1 (en) 2003-04-28
RU2148411C1 (en) 2000-05-10
HUT76530A (en) 1997-09-29
SK56696A3 (en) 1996-10-02
ATE228533T1 (en) 2002-12-15
CN1134157A (en) 1996-10-23
EP0726907A1 (en) 1996-08-21
EP0726907B1 (en) 2002-11-27
FI961900A0 (en) 1996-05-03
DE59410213D1 (en) 2003-01-09
SK284215B6 (en) 2004-11-03
PL314185A1 (en) 1996-09-02
AU7810994A (en) 1995-05-23
UA43855C2 (en) 2002-01-15
HU9601192D0 (en) 1996-06-28
JP3739788B2 (en) 2006-01-25

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