FI961900A - Process for Preparation of Virus Inactivated Factor VIII Containing Fraction by Chromatographic Procedures - Google Patents

Process for Preparation of Virus Inactivated Factor VIII Containing Fraction by Chromatographic Procedures Download PDF

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Publication number
FI961900A
FI961900A FI961900A FI961900A FI961900A FI 961900 A FI961900 A FI 961900A FI 961900 A FI961900 A FI 961900A FI 961900 A FI961900 A FI 961900A FI 961900 A FI961900 A FI 961900A
Authority
FI
Finland
Prior art keywords
factor viii
containing fraction
preparation
chromatographic procedures
virus inactivated
Prior art date
Application number
FI961900A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI116569B (en
FI961900A0 (en
Inventor
Ales Strancar
Monika Andrea Stadler
Djuro Josic
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of FI961900A publication Critical patent/FI961900A/en
Publication of FI961900A0 publication Critical patent/FI961900A0/en
Application granted granted Critical
Publication of FI116569B publication Critical patent/FI116569B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A process for producing a virus-inactivated, factor VIII-containing fraction by chromatographic methods in which, starting with cryoprecipitate or blood plasma, possibly followed by a treatment with aluminium hydroxide, at least one separating operation is performed by membrane chromatography after the dissolution of the cryoprecipitate. The fractions are subjected to virus inactivation and preferably an additional pasteurisation step.
FI961900A 1993-11-04 1996-05-03 Method for Preparation of Virus-Activated Factor VIII-Containing Fraction by Chromatographic Methods FI116569B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4337573 1993-11-04
DE4337573A DE4337573C1 (en) 1993-11-04 1993-11-04 Process for the preparation of a virus-inactivated factor VIII-containing fraction by means of chromatographic methods
PCT/EP1994/003258 WO1995012609A1 (en) 1993-11-04 1994-09-30 Process for producing a virus-inactivated factor viii-containing fraction by chromatographic methods
EP9403258 1994-09-30

Publications (3)

Publication Number Publication Date
FI961900A true FI961900A (en) 1996-05-03
FI961900A0 FI961900A0 (en) 1996-05-03
FI116569B FI116569B (en) 2005-12-30

Family

ID=6501733

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961900A FI116569B (en) 1993-11-04 1996-05-03 Method for Preparation of Virus-Activated Factor VIII-Containing Fraction by Chromatographic Methods

Country Status (21)

Country Link
EP (1) EP0726907B1 (en)
JP (1) JP3739788B2 (en)
KR (1) KR960705841A (en)
CN (1) CN1109045C (en)
AT (1) ATE228533T1 (en)
AU (1) AU687451B2 (en)
CA (1) CA2175670C (en)
CZ (1) CZ290186B6 (en)
DE (2) DE4337573C1 (en)
ES (1) ES2182846T3 (en)
FI (1) FI116569B (en)
HU (1) HU222087B1 (en)
IL (1) IL111263A (en)
MY (1) MY113294A (en)
NO (1) NO317112B1 (en)
PL (1) PL181725B1 (en)
RU (1) RU2148411C1 (en)
SK (1) SK284215B6 (en)
UA (1) UA43855C2 (en)
WO (1) WO1995012609A1 (en)
ZA (1) ZA948667B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19618851C1 (en) * 1996-05-10 1997-07-24 Octapharma Ag Testing factor VIII containing preparations
US6057164A (en) * 1996-03-08 2000-05-02 Octapharma Ag Process for testing suitability of protein fractions containing factor VIII
ES2137878B1 (en) * 1997-12-01 2000-10-01 Grifols Grupo Sa PROCEDURE FOR OBTAINING AN ATTENUATED HUMAN PLASMA OF VIRUSES FOR THERAPEUTIC USE.
CN102066417B (en) 2008-06-24 2015-11-25 奥克塔法马股份有限公司 The method of purification and solidification Factor IX
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
DE3432083A1 (en) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg PASTEURIZED, ISOAGGLUTININ-FREE FACTOR VIII PREPARATION AND METHOD FOR THE PRODUCTION THEREOF
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
JPS62191042A (en) * 1986-02-17 1987-08-21 Kanegafuchi Chem Ind Co Ltd Blood coagulation factor viii adsorbent and method for purifying blood coagulation factor viii using same
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US4774323A (en) * 1987-06-29 1988-09-27 Rorer Pharmaceutical Corporation Purification of von Willebrand Factor solutions using gel permeation chromatography
US4795806A (en) * 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
CA2001720C (en) * 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
EP0367840B1 (en) * 1988-11-05 1993-02-03 Octapharma AG Process for producing by chromatography a non-infectious antihemophilic factor with high purity
CH678155A5 (en) * 1989-08-09 1991-08-15 Fischer Ag Georg
AT399818B (en) * 1992-04-24 1995-07-25 Immuno Ag METHOD FOR PRODUCING A HIGH PURIFIED VIRUS-SAFE FACTOR VIII PREPARATION

Also Published As

Publication number Publication date
HU222087B1 (en) 2003-04-28
AU687451B2 (en) 1998-02-26
ATE228533T1 (en) 2002-12-15
DE59410213D1 (en) 2003-01-09
NO961816L (en) 1996-05-03
UA43855C2 (en) 2002-01-15
KR960705841A (en) 1996-11-08
SK284215B6 (en) 2004-11-03
EP0726907B1 (en) 2002-11-27
JPH09504532A (en) 1997-05-06
CZ290186B6 (en) 2002-06-12
SK56696A3 (en) 1996-10-02
CZ118796A3 (en) 1996-12-11
ES2182846T3 (en) 2003-03-16
CN1109045C (en) 2003-05-21
IL111263A (en) 2000-07-16
EP0726907A1 (en) 1996-08-21
RU2148411C1 (en) 2000-05-10
CA2175670C (en) 2005-08-02
ZA948667B (en) 1995-07-07
FI116569B (en) 2005-12-30
MY113294A (en) 2002-01-31
NO961816D0 (en) 1996-05-03
HUT76530A (en) 1997-09-29
PL314185A1 (en) 1996-09-02
IL111263A0 (en) 1994-12-29
CN1134157A (en) 1996-10-23
CA2175670A1 (en) 1995-05-11
JP3739788B2 (en) 2006-01-25
PL181725B1 (en) 2001-09-28
FI961900A0 (en) 1996-05-03
HU9601192D0 (en) 1996-06-28
NO317112B1 (en) 2004-08-16
AU7810994A (en) 1995-05-23
WO1995012609A1 (en) 1995-05-11
DE4337573C1 (en) 1995-05-18

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