AU741946B2 - Substituted benzimidazole antiviral agents - Google Patents
Substituted benzimidazole antiviral agents Download PDFInfo
- Publication number
- AU741946B2 AU741946B2 AU50809/99A AU5080999A AU741946B2 AU 741946 B2 AU741946 B2 AU 741946B2 AU 50809/99 A AU50809/99 A AU 50809/99A AU 5080999 A AU5080999 A AU 5080999A AU 741946 B2 AU741946 B2 AU 741946B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- ylmethyl
- benzimidazol
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9338798P | 1998-07-20 | 1998-07-20 | |
| US60/093387 | 1998-07-20 | ||
| PCT/US1999/012398 WO2000004900A1 (en) | 1998-07-20 | 1999-07-20 | Substituted benzimidazole antiviral agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5080999A AU5080999A (en) | 2000-02-14 |
| AU741946B2 true AU741946B2 (en) | 2001-12-13 |
Family
ID=22238648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU50809/99A Ceased AU741946B2 (en) | 1998-07-20 | 1999-07-20 | Substituted benzimidazole antiviral agents |
Country Status (6)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04592B1 (et) | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica N.V. | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt |
| ATE457177T1 (de) * | 2000-05-03 | 2010-02-15 | Medimmune Llc | Kombinationstherapie zur behandlung respiratorischer krankheiten mittels antikörper und anti-entzündungs wirkstoffe |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| CA2494485A1 (en) * | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| WO2005042530A1 (en) | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
| GB0406280D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Chemical compounds |
| GB0501964D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Therapeutics Ltd | Chemical compounds |
| JP4980358B2 (ja) | 2005-09-19 | 2012-07-18 | アロー セラピューティクス リミテッド | Ｃ型肝炎感染症を治療するためのベンゾジアゼピン誘導体 |
| GB0520475D0 (en) * | 2005-10-07 | 2005-11-16 | Arrow Therapeutics Ltd | Chemical compounds |
| US20100158863A1 (en) * | 2006-01-11 | 2010-06-24 | Arrow Therapeutics Limited | Triazoloanilinopyrimidine derivatives for use as antiviral agents |
| KR101585584B1 (ko) * | 2007-08-27 | 2016-01-14 | 키네타 포 엘엘씨 | 아레나바이러스 감염을 치료하기 위한 항바이러스 약물 |
| WO2009062874A2 (en) * | 2007-11-15 | 2009-05-22 | F. Hoffmann-La Roche Ag | Benzimidazole derivatives and their use as fxr agonists |
| US9850251B2 (en) | 2013-12-10 | 2017-12-26 | Shandong Danhong Pharmaceutical Co., Ltd. | Imidazole derivative used as antiviral agent and use therof in preparation of medicament |
| ES2821649T3 (es) | 2015-06-08 | 2021-04-27 | Shangdong Danhong Pharmaceutical Co Ltd | Método para preparar derivados de imidazol e intermedios de los mismos y formas cristalinas |
| CN105820156A (zh) * | 2016-04-21 | 2016-08-03 | 广东工业大学 | 苯并三氮唑基苯并咪唑啉及其制备方法和应用 |
| GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3394141A (en) | 1965-11-12 | 1968-07-23 | Fabio Sparatore | Z-benzyaminobenzimidazoles |
| US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| DK154078C (da) | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| US5066656A (en) * | 1989-11-01 | 1991-11-19 | Janssen Pharmaceutica N.V. | Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives |
| US5256668A (en) | 1993-03-17 | 1993-10-26 | American Home Products Corporation | Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus |
| BR9700939A (pt) | 1996-02-13 | 1998-09-01 | American Cyanamid Co | Compostos aniônicos contendo traiazina úteis como agentes antivirais |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
-
1999
- 1999-07-20 WO PCT/US1999/012398 patent/WO2000004900A1/en active IP Right Grant
- 1999-07-20 EP EP99935302A patent/EP1098644A1/en not_active Withdrawn
- 1999-07-20 CA CA002338147A patent/CA2338147A1/en not_active Abandoned
- 1999-07-20 JP JP2000560893A patent/JP2002521334A/ja not_active Abandoned
- 1999-07-20 AU AU50809/99A patent/AU741946B2/en not_active Ceased
-
2002
- 2002-11-07 US US10/289,829 patent/US6908936B2/en not_active Expired - Fee Related
-
2004
- 2004-09-03 US US10/934,921 patent/US7030140B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002521334A (ja) | 2002-07-16 |
| US7030140B2 (en) | 2006-04-18 |
| WO2000004900A1 (en) | 2000-02-03 |
| EP1098644A1 (en) | 2001-05-16 |
| US20050038085A1 (en) | 2005-02-17 |
| US20030139450A1 (en) | 2003-07-24 |
| CA2338147A1 (en) | 2000-02-03 |
| AU5080999A (en) | 2000-02-14 |
| US6908936B2 (en) | 2005-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |