AU731725B2 - Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof - Google Patents
Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof Download PDFInfo
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- AU731725B2 AU731725B2 AU43455/97A AU4345597A AU731725B2 AU 731725 B2 AU731725 B2 AU 731725B2 AU 43455/97 A AU43455/97 A AU 43455/97A AU 4345597 A AU4345597 A AU 4345597A AU 731725 B2 AU731725 B2 AU 731725B2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2697896P | 1996-09-20 | 1996-09-20 | |
| US60/026978 | 1996-09-20 | ||
| US08/928958 | 1997-09-12 | ||
| US08/928,958 US5877282A (en) | 1996-09-20 | 1997-09-12 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
| PCT/US1997/016217 WO1998011907A1 (en) | 1996-09-20 | 1997-09-15 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
Publications (2)
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| AU4345597A AU4345597A (en) | 1998-04-14 |
| AU731725B2 true AU731725B2 (en) | 2001-04-05 |
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| AU43455/97A Ceased AU731725B2 (en) | 1996-09-20 | 1997-09-15 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
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| US (1) | US5877282A (enExample) |
| EP (1) | EP1015012A4 (enExample) |
| JP (1) | JP2002514053A (enExample) |
| AU (1) | AU731725B2 (enExample) |
| CA (1) | CA2265571A1 (enExample) |
| TW (1) | TW575580B (enExample) |
| WO (1) | WO1998011907A1 (enExample) |
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|---|---|---|---|---|
| US6495518B1 (en) | 1994-06-13 | 2002-12-17 | Vanderbilt University | Method for importing biologically active molecules into cells |
| US7553929B2 (en) * | 1994-06-13 | 2009-06-30 | Vanderbilt University | Cell permeable peptides for inhibition of inflammatory reactions and methods of use |
| FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US5962415A (en) * | 1996-09-20 | 1999-10-05 | Bristol-Myers Squibb Co. | Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof |
| GB2337329B (en) * | 1997-04-30 | 2001-09-05 | Imp Cancer Res Tech | Inhibitors of nuclear protein/nuclear receptor interaction |
| GB9708676D0 (en) * | 1997-04-30 | 1997-06-18 | Imp Cancer Res Tech | Chemical compounds |
| ATE419273T1 (de) * | 1998-11-13 | 2009-01-15 | Cyclacel Ltd | Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 |
| AU5011400A (en) * | 1999-05-14 | 2000-12-05 | Arbor Vita Corporation | Molecular interactions in t cells |
| EP1196449B1 (en) | 1999-06-28 | 2008-02-06 | Inter-K Pty Limited | A method of modulating integrin mediated cellular activity and agents useful for same |
| DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| US6312956B1 (en) | 1999-10-01 | 2001-11-06 | Vanderbilt University | Nuclear targeted peptide nucleic acid oligomer |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6844324B1 (en) * | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
| CA2392490A1 (en) * | 1999-11-24 | 2001-05-31 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| EP1862471A3 (en) * | 2000-02-07 | 2008-05-28 | Wisconsin Alumni Research Foundation | Pharmacologically active antiviral peptides and methods of their use |
| DE60130641T2 (de) * | 2000-02-07 | 2008-06-26 | Wisconsin Alumni Research Foundation, Madison | Pharmakologisch aktive antivirale peptide und methoden zu ihrer anwendung |
| GB0103110D0 (en) | 2000-08-25 | 2001-03-28 | Aventis Pharma Inc | A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1 |
| US20040086896A1 (en) * | 2001-04-19 | 2004-05-06 | Julie Carman | Polynucleotides and polypeptides associated with the NF-kB pathway |
| EP1379540A4 (en) * | 2001-04-19 | 2005-11-16 | Bristol Myers Squibb Co | POLYNUCLEOTIDES AND POLYPEPTIDES ASSOCIATED WITH NF-KB PATH |
| DE60335101D1 (de) * | 2002-04-25 | 2011-01-05 | Toagosei Co Ltd | Antimikrobielles polypeptid und nutzung davon |
| WO2005037308A1 (en) | 2003-10-17 | 2005-04-28 | Inter-K Pty Limited | Methods and agents for the treatment of cancer |
| JP4524671B2 (ja) * | 2003-10-29 | 2010-08-18 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| US7432045B2 (en) * | 2003-12-01 | 2008-10-07 | Wisconsin Alumni Research Foundation | Method of inhibiting influenza infection with antiviral peptides |
| US20050203150A1 (en) * | 2004-03-09 | 2005-09-15 | Haffar Omar K. | Compounds, compositions and methods for inhibiting or treating HIV-1 |
| JP4507080B2 (ja) * | 2004-07-30 | 2010-07-21 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| WO2006056227A1 (en) * | 2004-11-27 | 2006-06-01 | Eberhard-Karls- Universität Tübingen Universitätsklinikum | Conjugates comprising the active agent and flanking or branched-chain peptides |
| JP4730584B2 (ja) | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| WO2006088010A1 (ja) * | 2005-02-15 | 2006-08-24 | Toagosei Co., Ltd. | 抗菌ペプチド及びその利用 |
| US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| JP2011512364A (ja) * | 2008-02-22 | 2011-04-21 | インター−ケイ ピーティーワイ リミテッド | 治療用ペプチド |
| WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2010006377A1 (en) | 2008-07-17 | 2010-01-21 | Nutripep Pty Limited | Therapeutic agents |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのｊｎｋシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| PL3013353T3 (pl) | 2013-06-26 | 2021-09-20 | Xigen Inflammation Ltd. | Przenikające do komórki inhibitory peptydowe szlaku przekazywania sygnału jnk do leczenia zapalenia pęcherza |
| JP6554099B2 (ja) | 2013-08-07 | 2019-07-31 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． | ｐ５３変異体を再活性化することの可能なペプチド |
| KR20150050646A (ko) * | 2013-10-29 | 2015-05-11 | 삼성전자주식회사 | 융합 펩타이드 및 이의 세포막투과를 위한 용도 |
| RU2762089C2 (ru) * | 2016-02-04 | 2021-12-15 | Иеда Рисеч Энд Девелопмент Ко. Лтд. | ПЕПТИДЫ И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, НАРУШЕНИЙ ИЛИ СОСТОЯНИЙ, АССОЦИИРОВАННЫХ С МУТАНТНЫМ р53 |
| WO2021167324A1 (en) * | 2020-02-18 | 2021-08-26 | Cellivery Therapeutics, Inc. | Improved cell-permeable nuclear import inhibitor synthetic peptide for inhibition of cytokine storm or inflammatory disease and use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004696A1 (en) * | 1992-08-25 | 1994-03-03 | Miles Inc. | Translocation signal facilitated nuclear delivery of macromolecules |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| EP1188448A3 (en) * | 1994-03-15 | 2002-04-17 | Prizm Pharmaceuticals, Inc. | Heparin-binding growth factors for gene therapy and anterior eye disorders |
| EP0767678A1 (en) * | 1994-05-23 | 1997-04-16 | Gideon Goldstein | Compositions of transactivating proteins of human immunodeficiency virus |
| US5807746A (en) * | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
-
1997
- 1997-09-12 US US08/928,958 patent/US5877282A/en not_active Expired - Lifetime
- 1997-09-15 CA CA002265571A patent/CA2265571A1/en not_active Abandoned
- 1997-09-15 WO PCT/US1997/016217 patent/WO1998011907A1/en not_active Ceased
- 1997-09-15 AU AU43455/97A patent/AU731725B2/en not_active Ceased
- 1997-09-15 JP JP51477498A patent/JP2002514053A/ja not_active Withdrawn
- 1997-09-15 EP EP97941572A patent/EP1015012A4/en not_active Withdrawn
- 1997-09-19 TW TW86113642A patent/TW575580B/zh not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004696A1 (en) * | 1992-08-25 | 1994-03-03 | Miles Inc. | Translocation signal facilitated nuclear delivery of macromolecules |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2265571A1 (en) | 1998-03-26 |
| AU4345597A (en) | 1998-04-14 |
| US5877282A (en) | 1999-03-02 |
| EP1015012A4 (en) | 2004-09-29 |
| TW575580B (en) | 2004-02-11 |
| JP2002514053A (ja) | 2002-05-14 |
| WO1998011907A1 (en) | 1998-03-26 |
| EP1015012A1 (en) | 2000-07-05 |
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