TW575580B - Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and pharmaceutical compositions containing the same - Google Patents
Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and pharmaceutical compositions containing the same Download PDFInfo
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- TW575580B TW575580B TW86113642A TW86113642A TW575580B TW 575580 B TW575580 B TW 575580B TW 86113642 A TW86113642 A TW 86113642A TW 86113642 A TW86113642 A TW 86113642A TW 575580 B TW575580 B TW 575580B
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- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2697896P | 1996-09-20 | 1996-09-20 | |
| US08/928,958 US5877282A (en) | 1996-09-20 | 1997-09-12 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW575580B true TW575580B (en) | 2004-02-11 |
Family
ID=26701884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW86113642A TW575580B (en) | 1996-09-20 | 1997-09-19 | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and pharmaceutical compositions containing the same |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5877282A (enExample) |
| EP (1) | EP1015012A4 (enExample) |
| JP (1) | JP2002514053A (enExample) |
| AU (1) | AU731725B2 (enExample) |
| CA (1) | CA2265571A1 (enExample) |
| TW (1) | TW575580B (enExample) |
| WO (1) | WO1998011907A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553929B2 (en) * | 1994-06-13 | 2009-06-30 | Vanderbilt University | Cell permeable peptides for inhibition of inflammatory reactions and methods of use |
| US6495518B1 (en) | 1994-06-13 | 2002-12-17 | Vanderbilt University | Method for importing biologically active molecules into cells |
| FR2739621B1 (fr) * | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US5962415A (en) * | 1996-09-20 | 1999-10-05 | Bristol-Myers Squibb Co. | Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof |
| GB9708676D0 (en) * | 1997-04-30 | 1997-06-18 | Imp Cancer Res Tech | Chemical compounds |
| GB2337329B (en) * | 1997-04-30 | 2001-09-05 | Imp Cancer Res Tech | Inhibitors of nuclear protein/nuclear receptor interaction |
| CZ20011671A3 (cs) * | 1998-11-13 | 2001-10-17 | Cyclacel Limited | Peptidová nosná skupina pro transport |
| AU5011400A (en) * | 1999-05-14 | 2000-12-05 | Arbor Vita Corporation | Molecular interactions in t cells |
| US8119594B1 (en) | 1999-06-28 | 2012-02-21 | Inter-K Pty Limited | Method of modulating integrin mediated cellular activity and agents useful for same |
| DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| US6312956B1 (en) * | 1999-10-01 | 2001-11-06 | Vanderbilt University | Nuclear targeted peptide nucleic acid oligomer |
| US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| US6844324B1 (en) * | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
| AU785007B2 (en) * | 1999-11-24 | 2006-08-24 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| ATE374208T1 (de) * | 2000-02-07 | 2007-10-15 | Wisconsin Alumni Res Found | Pharmakologisch aktive antivirale peptide und methoden zu ihrer anwendung |
| EP1862471A3 (en) * | 2000-02-07 | 2008-05-28 | Wisconsin Alumni Research Foundation | Pharmacologically active antiviral peptides and methods of their use |
| GB0103110D0 (en) | 2000-08-25 | 2001-03-28 | Aventis Pharma Inc | A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1 |
| US20040086896A1 (en) * | 2001-04-19 | 2004-05-06 | Julie Carman | Polynucleotides and polypeptides associated with the NF-kB pathway |
| AU2002252705A1 (en) * | 2001-04-19 | 2002-11-05 | Bristol-Myers Squibb Company | Polynucleotides and polypeptides associated with the nf-kb pathway |
| AU2003231471A1 (en) * | 2002-04-25 | 2003-11-10 | Toagosei Co., Ltd. | Antimicrobial polypeptide and utizliation thereof |
| WO2005037308A1 (en) * | 2003-10-17 | 2005-04-28 | Inter-K Pty Limited | Methods and agents for the treatment of cancer |
| EP1688486B1 (en) * | 2003-10-29 | 2016-12-14 | Toagosei Co., Ltd. | Antibacterial peptide and utilization of the same |
| US7432045B2 (en) * | 2003-12-01 | 2008-10-07 | Wisconsin Alumni Research Foundation | Method of inhibiting influenza infection with antiviral peptides |
| US20050203150A1 (en) * | 2004-03-09 | 2005-09-15 | Haffar Omar K. | Compounds, compositions and methods for inhibiting or treating HIV-1 |
| JP4507080B2 (ja) * | 2004-07-30 | 2010-07-21 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| WO2006056227A1 (en) * | 2004-11-27 | 2006-06-01 | Eberhard-Karls- Universität Tübingen Universitätsklinikum | Conjugates comprising the active agent and flanking or branched-chain peptides |
| JP4730584B2 (ja) * | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| WO2006088010A1 (ja) * | 2005-02-15 | 2006-08-24 | Toagosei Co., Ltd. | 抗菌ペプチド及びその利用 |
| US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| EP2254901A4 (en) * | 2008-02-22 | 2012-02-22 | Inter K Pty Ltd | THERAPEUTIC PEPTIDES |
| WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| EP2454276A4 (en) | 2008-07-17 | 2013-07-10 | Inter K Pty Ltd | THERAPEUTIC AGENTS |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| CA2807036C (en) | 2010-10-14 | 2018-01-16 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| CA2903275A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2015019318A1 (en) | 2013-08-07 | 2015-02-12 | Yeda Research And Development Co. Ltd. | Peptides capable of reactivating p53 mutants |
| KR20150050646A (ko) * | 2013-10-29 | 2015-05-11 | 삼성전자주식회사 | 융합 펩타이드 및 이의 세포막투과를 위한 용도 |
| CA3012302A1 (en) * | 2016-02-04 | 2017-08-10 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53 |
| CA3160603A1 (en) * | 2020-02-18 | 2021-08-26 | Daewoong Jo | Improved cell-permeable nuclear import inhibitor synthetic peptide for inhibition of cytokine storm or inflammatory disease and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| IL106760A (en) * | 1992-08-25 | 1999-12-31 | Miles Inc | Protein-nucleic acid hybrid construct for translocating an exogenous nucleic acid into a target cell and nucleus |
| EP1188448A3 (en) * | 1994-03-15 | 2002-04-17 | Prizm Pharmaceuticals, Inc. | Heparin-binding growth factors for gene therapy and anterior eye disorders |
| CA2190972A1 (en) * | 1994-05-23 | 1995-11-30 | Gideon Goldstein | Compositions of transactivating proteins of human immunodeficiency virus |
| US5807746A (en) * | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
-
1997
- 1997-09-12 US US08/928,958 patent/US5877282A/en not_active Expired - Lifetime
- 1997-09-15 EP EP97941572A patent/EP1015012A4/en not_active Withdrawn
- 1997-09-15 JP JP51477498A patent/JP2002514053A/ja not_active Withdrawn
- 1997-09-15 CA CA002265571A patent/CA2265571A1/en not_active Abandoned
- 1997-09-15 WO PCT/US1997/016217 patent/WO1998011907A1/en not_active Ceased
- 1997-09-15 AU AU43455/97A patent/AU731725B2/en not_active Ceased
- 1997-09-19 TW TW86113642A patent/TW575580B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU731725B2 (en) | 2001-04-05 |
| US5877282A (en) | 1999-03-02 |
| EP1015012A4 (en) | 2004-09-29 |
| WO1998011907A1 (en) | 1998-03-26 |
| AU4345597A (en) | 1998-04-14 |
| CA2265571A1 (en) | 1998-03-26 |
| EP1015012A1 (en) | 2000-07-05 |
| JP2002514053A (ja) | 2002-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |