AU731123B2 - Human endokine alpha - Google Patents
Human endokine alpha Download PDFInfo
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- AU731123B2 AU731123B2 AU68478/96A AU6847896A AU731123B2 AU 731123 B2 AU731123 B2 AU 731123B2 AU 68478/96 A AU68478/96 A AU 68478/96A AU 6847896 A AU6847896 A AU 6847896A AU 731123 B2 AU731123 B2 AU 731123B2
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- nucleic acid
- acid molecule
- polynucleotide
- seq
- polypeptide
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
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- Microbiology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU53937/01A AU764278B2 (en) | 1996-08-16 | 2001-06-20 | Human endokine alpha |
| AU2003257892A AU2003257892A1 (en) | 1996-08-16 | 2003-10-28 | Human Endokine Alpha |
| AU2007202630A AU2007202630B8 (en) | 1996-08-16 | 2007-06-08 | Human Endokine Alpha |
Applications Claiming Priority (1)
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| PCT/US1996/013282 WO1998007880A1 (en) | 1996-08-16 | 1996-08-16 | Human endokine alpha |
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| AU53937/01A Division AU764278B2 (en) | 1996-08-16 | 2001-06-20 | Human endokine alpha |
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| AU6847896A AU6847896A (en) | 1998-03-06 |
| AU731123B2 true AU731123B2 (en) | 2001-03-22 |
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| AU53937/01A Withdrawn - After Issue AU764278B2 (en) | 1996-08-16 | 2001-06-20 | Human endokine alpha |
| AU2003257892A Abandoned AU2003257892A1 (en) | 1996-08-16 | 2003-10-28 | Human Endokine Alpha |
| AU2007202630A Ceased AU2007202630B8 (en) | 1996-08-16 | 2007-06-08 | Human Endokine Alpha |
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| AU53937/01A Withdrawn - After Issue AU764278B2 (en) | 1996-08-16 | 2001-06-20 | Human endokine alpha |
| AU2003257892A Abandoned AU2003257892A1 (en) | 1996-08-16 | 2003-10-28 | Human Endokine Alpha |
| AU2007202630A Ceased AU2007202630B8 (en) | 1996-08-16 | 2007-06-08 | Human Endokine Alpha |
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|---|---|
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| JP (1) | JP2000516474A (enExample) |
| KR (1) | KR20010102191A (enExample) |
| AT (1) | ATE412740T1 (enExample) |
| AU (4) | AU731123B2 (enExample) |
| CA (1) | CA2264200A1 (enExample) |
| DE (1) | DE69637734D1 (enExample) |
| DK (1) | DK0961831T3 (enExample) |
| ES (1) | ES2316153T3 (enExample) |
| NZ (1) | NZ334035A (enExample) |
| WO (1) | WO1998007880A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6406867B1 (en) | 1996-08-16 | 2002-06-18 | Human Genome Sciences, Inc. | Antibody to human endokine alpha and methods of use |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| WO2001040464A1 (en) * | 1999-11-30 | 2001-06-07 | Genentech, Inc. | Interleukin-1-receptor associated kinase-3 (irak3) and its use in promotion or inhibition of angiogenesis and cardiovascularization |
| WO2000073445A2 (en) * | 1999-06-02 | 2000-12-07 | Genentech, Inc. | Interleukin-1-receptor associated kinase-3 (irak3) |
| US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| CA2308365A1 (en) * | 1997-11-18 | 1999-05-27 | Genentech, Inc. | Dna19355 polypeptide, a tumor necrosis factor homolog |
| JP2002537769A (ja) * | 1999-02-26 | 2002-11-12 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ヒトエンドカインαおよび使用方法 |
| AU6391000A (en) * | 1999-07-28 | 2001-02-19 | Genentech Inc. | Method of preventing the injury or death of retinal cells and treating ocular diseases |
| CA2405550A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| WO2001096528A2 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
| EP2275449B1 (en) | 2000-06-16 | 2016-09-28 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| US20030091565A1 (en) | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
| DK1572874T3 (da) | 2001-05-25 | 2013-12-16 | Human Genome Sciences Inc | Antistoffer, der immunospecifikt binder til TRAIL receptorer |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| EA015860B1 (ru) | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| WO2010036986A2 (en) | 2008-09-26 | 2010-04-01 | Tocagen Inc. | Recombinant vectors |
| AR084141A1 (es) | 2010-11-19 | 2013-04-24 | Imai Toshio | Anticuerpos neutralizadores anti-ccl20 |
| NL2005893C2 (nl) | 2010-12-22 | 2012-06-25 | Vanderlande Ind Bv | Systeem en werkwijze voor het bufferen van bagagestukken. |
| EP2909324B1 (en) | 2012-10-25 | 2020-02-26 | Tocagen Inc. | Retroviral vector with mini-promoter cassette |
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US599817A (en) * | 1898-03-01 | Cash-register | ||
| US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4433092A (en) | 1981-03-09 | 1984-02-21 | Champion Spark Plug Company | Green ceramic of lead-free glass, conductive carbon, silicone resin and AlPO4, useful, after firing, as an electrical resistor |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE3472793D1 (en) * | 1983-12-26 | 1988-08-25 | Asahi Chemical Ind | A novel physiologically active polypeptide |
| DE3586772T2 (de) | 1984-07-24 | 1993-03-04 | Coselco Mimotopes Pty Ltd | Verfahren zur bestimmung von mimotopen. |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| EP0232262A4 (en) | 1985-08-15 | 1989-09-19 | Stauffer Chemical Co | TRYPTOPHANE GENERATING MICROORGANISM. |
| EP0212489B1 (en) * | 1985-08-16 | 1994-11-30 | The Rockefeller University | Anabolic activity modulator and uses thereof |
| US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
| LU86128A1 (fr) | 1985-10-18 | 1987-06-02 | Vander Poorten Henri | Procede permettant l'impression ou le revetement de ceramique simultanement a son electroformage et conduisant en monocuisson a des produits decoratifs ou techniques |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| JP2647427B2 (ja) * | 1987-04-24 | 1997-08-27 | 帝人株式会社 | 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| DK0464533T3 (da) | 1990-06-28 | 1999-04-26 | Gen Hospital Corp | Fusionsproteiner med immunglobulindele, deres fremstilling og anvendelse |
| US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
| AU708972B2 (en) * | 1994-11-07 | 1999-08-19 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US5998171A (en) * | 1996-08-16 | 1999-12-07 | Human Genome Sciences, Inc. | Polynucleotides encoding human endokine alpha |
-
1996
- 1996-08-16 ES ES96928886T patent/ES2316153T3/es not_active Expired - Lifetime
- 1996-08-16 WO PCT/US1996/013282 patent/WO1998007880A1/en not_active Ceased
- 1996-08-16 CA CA002264200A patent/CA2264200A1/en not_active Abandoned
- 1996-08-16 AU AU68478/96A patent/AU731123B2/en not_active Ceased
- 1996-08-16 JP JP10510675A patent/JP2000516474A/ja not_active Withdrawn
- 1996-08-16 KR KR1020017010401A patent/KR20010102191A/ko not_active Ceased
- 1996-08-16 DK DK96928886T patent/DK0961831T3/da active
- 1996-08-16 DE DE69637734T patent/DE69637734D1/de not_active Expired - Lifetime
- 1996-08-16 NZ NZ334035A patent/NZ334035A/xx not_active IP Right Cessation
- 1996-08-16 EP EP08018826A patent/EP2025682A3/en not_active Withdrawn
- 1996-08-16 AT AT96928886T patent/ATE412740T1/de active
- 1996-08-16 EP EP96928886A patent/EP0961831B1/en not_active Expired - Lifetime
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2001
- 2001-06-20 AU AU53937/01A patent/AU764278B2/en not_active Withdrawn - After Issue
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2003
- 2003-10-28 AU AU2003257892A patent/AU2003257892A1/en not_active Abandoned
-
2007
- 2007-06-08 AU AU2007202630A patent/AU2007202630B8/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US599817A (en) * | 1898-03-01 | Cash-register | ||
| US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5393701A (en) | 2001-08-16 |
| EP0961831A1 (en) | 1999-12-08 |
| ES2316153T3 (es) | 2009-04-01 |
| EP2025682A3 (en) | 2009-06-17 |
| JP2000516474A (ja) | 2000-12-12 |
| EP2025682A2 (en) | 2009-02-18 |
| DK0961831T3 (da) | 2009-01-12 |
| EP0961831B1 (en) | 2008-10-29 |
| NZ334035A (en) | 2000-09-29 |
| AU764278B2 (en) | 2003-08-14 |
| AU2007202630B2 (en) | 2010-04-22 |
| ATE412740T1 (de) | 2008-11-15 |
| AU2007202630A1 (en) | 2007-06-28 |
| AU2007202630B8 (en) | 2010-08-19 |
| EP0961831A4 (en) | 2002-06-12 |
| KR20010102191A (ko) | 2001-11-15 |
| CA2264200A1 (en) | 1998-02-26 |
| AU2003257892A1 (en) | 2003-11-20 |
| WO1998007880A1 (en) | 1998-02-26 |
| AU6847896A (en) | 1998-03-06 |
| DE69637734D1 (de) | 2008-12-11 |
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