AU729055B2 - Aldolase catalytic antibody - Google Patents

Aldolase catalytic antibody Download PDF

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Publication number
AU729055B2
AU729055B2 AU12923/97A AU1292397A AU729055B2 AU 729055 B2 AU729055 B2 AU 729055B2 AU 12923/97 A AU12923/97 A AU 12923/97A AU 1292397 A AU1292397 A AU 1292397A AU 729055 B2 AU729055 B2 AU 729055B2
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AU
Australia
Prior art keywords
antibody
reaction
aldol
antibody molecules
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU12923/97A
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English (en)
Other versions
AU1292397A (en
Inventor
Carlos F. Barbas Iii
Richard A. Lerner
Juergen Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
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Scripps Research Institute
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Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU1292397A publication Critical patent/AU1292397A/en
Application granted granted Critical
Publication of AU729055B2 publication Critical patent/AU729055B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU12923/97A 1995-12-15 1996-12-16 Aldolase catalytic antibody Expired AU729055B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/573,415 US5733757A (en) 1995-12-15 1995-12-15 Aldolase catalytic antibody
US08/573415 1995-12-15
PCT/US1996/020052 WO1997021803A1 (en) 1995-12-15 1996-12-16 Aldolase catalytic antibody

Publications (2)

Publication Number Publication Date
AU1292397A AU1292397A (en) 1997-07-03
AU729055B2 true AU729055B2 (en) 2001-01-25

Family

ID=24291910

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12923/97A Expired AU729055B2 (en) 1995-12-15 1996-12-16 Aldolase catalytic antibody

Country Status (12)

Country Link
US (3) US5733757A (sl)
EP (1) EP0870014B9 (sl)
JP (1) JP3996642B2 (sl)
AT (1) ATE354644T1 (sl)
AU (1) AU729055B2 (sl)
CA (1) CA2239167C (sl)
DE (1) DE69636923T2 (sl)
DK (1) DK0870014T3 (sl)
ES (1) ES2283009T3 (sl)
PT (1) PT870014E (sl)
SI (1) SI0870014T1 (sl)
WO (1) WO1997021803A1 (sl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1927799A (en) * 1997-12-18 1999-07-05 Scripps Research Institute, The Aldol condensations by catalytic antibodies
US6326176B1 (en) 1997-12-18 2001-12-04 The Scripps Research Institute Aldol condensations by catalytic antibodies
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6294374B1 (en) * 1999-10-08 2001-09-25 The Scripps Research Institute Use of catalytic antibodies for synthesizing epothilone
US20040048312A1 (en) * 2002-04-12 2004-03-11 Ronghao Li Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
AU2006235781B2 (en) * 2004-04-27 2008-04-03 Teddy Yeung Man Lo LED illuminated glow stick
EP2292248A3 (en) 2005-03-03 2011-06-29 CovX Technologies Ireland Limited Anti-angiogenic compounds
PT2089425E (pt) * 2006-11-10 2011-10-17 Covx Technologies Ireland Ltd Compostos anti-angiogénicos
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
EP3492488A1 (en) 2007-08-22 2019-06-05 The Regents of The University of California Activatable binding polypeptides and methods of identification and use thereof
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
US8340951B2 (en) * 2007-12-13 2012-12-25 University Of Washington Synthetic enzymes derived from computational design
JP5731827B2 (ja) 2008-03-03 2015-06-10 グライコフィ， インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
US8293714B2 (en) 2008-05-05 2012-10-23 Covx Technology Ireland, Ltd. Anti-angiogenic compounds
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
JP5851842B2 (ja) 2009-01-12 2016-02-03 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. 改変した抗体組成物、それを作製および使用する方法
US8399219B2 (en) 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
EP2401378B1 (en) 2009-02-25 2013-08-14 Merck Sharp & Dohme Corp. Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
JP5913307B2 (ja) 2010-07-12 2016-04-27 コヴェックス・テクノロジーズ・アイルランド・リミテッド 多機能性抗体複合体
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
BR112013003587B1 (pt) 2010-08-20 2022-11-08 Wyeth Llc Proteínas osteogênicas projetadas, seus usos, seu método de produção e molécula de ácido nucleico isolada
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
AU2011324886A1 (en) 2010-11-05 2013-05-23 Covx Technologies Ireland Limited Anti-diabetic compounds
WO2012162561A2 (en) 2011-05-24 2012-11-29 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
CA2860109C (en) 2011-12-20 2016-08-09 Javier Magano Improved processes for preparing peptide conjugates and linkers
WO2013093720A2 (en) 2011-12-22 2013-06-27 Pfizer Inc. Anti-diabetic compounds
CA2861137C (en) 2012-02-03 2022-03-22 The Governors Of The University Of Alberta Method of quantifying peptide-derivative libraries using phage display
CN105451767B (zh) 2013-03-15 2019-10-18 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
EP3863672A4 (en) * 2018-10-11 2022-06-29 The Scripps Research Institute Antibody compounds with reactive arginine and related antibody drug conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571681A (en) * 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ACTA CHEM. SCAN. AUGUST 1996, VOL 50 NO. 8 PAGES 672-678 *
SCIENCE 15 DEC 1995 VOL 270 PAGES 1797-1800 *

Also Published As

Publication number Publication date
JP3996642B2 (ja) 2007-10-24
US5985626A (en) 1999-11-16
US6368839B1 (en) 2002-04-09
SI0870014T1 (sl) 2007-08-31
EP0870014B9 (en) 2007-10-10
EP0870014B1 (en) 2007-02-21
CA2239167C (en) 2009-09-22
US5733757A (en) 1998-03-31
EP0870014A4 (en) 2002-03-13
WO1997021803A1 (en) 1997-06-19
DE69636923D1 (de) 2007-04-05
EP0870014A1 (en) 1998-10-14
DK0870014T3 (da) 2007-06-11
AU1292397A (en) 1997-07-03
JPH11510063A (ja) 1999-09-07
CA2239167A1 (en) 1997-06-19
PT870014E (pt) 2007-05-31
ATE354644T1 (de) 2007-03-15
ES2283009T3 (es) 2007-10-16
DE69636923T2 (de) 2007-11-08

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