AU724862B2 - Polysaccharide precipitation process - Google Patents

Polysaccharide precipitation process Download PDF

Info

Publication number
AU724862B2
AU724862B2 AU22677/97A AU2267797A AU724862B2 AU 724862 B2 AU724862 B2 AU 724862B2 AU 22677/97 A AU22677/97 A AU 22677/97A AU 2267797 A AU2267797 A AU 2267797A AU 724862 B2 AU724862 B2 AU 724862B2
Authority
AU
Australia
Prior art keywords
polysaccharide
organic solvent
pneumococcus
covalent modification
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU22677/97A
Other languages
English (en)
Other versions
AU2267797A (en
Inventor
Russel J. Lander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9608546A external-priority patent/GB9608546D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2267797A publication Critical patent/AU2267797A/en
Application granted granted Critical
Publication of AU724862B2 publication Critical patent/AU724862B2/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: MERCK & CO., INC.
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU22677/97A 1996-02-14 1997-02-10 Polysaccharide precipitation process Ceased AU724862B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1163196P 1996-02-14 1996-02-14
US60/011631 1996-02-14
GB9608546 1996-04-25
GB9608546A GB9608546D0 (en) 1996-04-25 1996-04-25 Polysaccharide precipitation process
PCT/US1997/002124 WO1997030171A1 (fr) 1996-02-14 1997-02-10 Procede de precipitation de polysaccharides

Publications (2)

Publication Number Publication Date
AU2267797A AU2267797A (en) 1997-09-02
AU724862B2 true AU724862B2 (en) 2000-10-05

Family

ID=26309205

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22677/97A Ceased AU724862B2 (en) 1996-02-14 1997-02-10 Polysaccharide precipitation process

Country Status (13)

Country Link
EP (1) EP0897427B1 (fr)
JP (1) JP3990455B2 (fr)
AR (1) AR005869A1 (fr)
AT (1) ATE280834T1 (fr)
AU (1) AU724862B2 (fr)
CA (1) CA2245588C (fr)
DE (1) DE69731380T2 (fr)
DK (1) DK0897427T3 (fr)
ES (1) ES2229336T3 (fr)
HR (1) HRP970083A2 (fr)
PT (1) PT897427E (fr)
TW (1) TW411344B (fr)
WO (1) WO1997030171A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1603340A (en) * 1977-04-29 1981-11-25 Fabre Sa Pierre Potentiated acellular vaccines
US4686102A (en) * 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4877613A (en) * 1987-08-05 1989-10-31 Biotech Connections, Inc. Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
SK18594A3 (en) * 1991-08-16 1994-08-10 Merck & Co Inc Method of production of capsular polysacharide without lipid and endotoxine
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5445817A (en) * 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1603340A (en) * 1977-04-29 1981-11-25 Fabre Sa Pierre Potentiated acellular vaccines
US4686102A (en) * 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof

Also Published As

Publication number Publication date
DE69731380T2 (de) 2006-02-23
DK0897427T3 (da) 2005-02-14
EP0897427B1 (fr) 2004-10-27
CA2245588C (fr) 2006-05-09
JP2000506383A (ja) 2000-05-30
CA2245588A1 (fr) 1997-08-21
AR005869A1 (es) 1999-07-21
JP3990455B2 (ja) 2007-10-10
PT897427E (pt) 2005-01-31
AU2267797A (en) 1997-09-02
EP0897427A1 (fr) 1999-02-24
DE69731380D1 (de) 2004-12-02
ES2229336T3 (es) 2005-04-16
WO1997030171A1 (fr) 1997-08-21
HRP970083A2 (en) 1998-04-30
ATE280834T1 (de) 2004-11-15
TW411344B (en) 2000-11-11

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)