AU714917B2 - Libraries of backbone-cyclized peptidomimetics - Google Patents

Libraries of backbone-cyclized peptidomimetics

Info

Publication number
AU714917B2
AU714917B2 AU68361/96A AU6836196A AU714917B2 AU 714917 B2 AU714917 B2 AU 714917B2 AU 68361/96 A AU68361/96 A AU 68361/96A AU 6836196 A AU6836196 A AU 6836196A AU 714917 B2 AU714917 B2 AU 714917B2
Authority
AU
Australia
Prior art keywords
group
peptide
amino acid
gly
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68361/96A
Other languages
English (en)
Other versions
AU6836196A (en
Inventor
Chaim Gilon
Vered Hornik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peptor Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Peptor Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11509695A external-priority patent/IL115096A/xx
Application filed by Peptor Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Peptor Ltd
Publication of AU6836196A publication Critical patent/AU6836196A/en
Application granted granted Critical
Publication of AU714917B2 publication Critical patent/AU714917B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU68361/96A 1995-08-29 1996-08-28 Libraries of backbone-cyclized peptidomimetics Ceased AU714917B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL11509695A IL115096A (en) 1995-08-29 1995-08-29 Libraries of backbone cyclized peptidomimetics
IL115096 1995-08-29
US08/569,042 US6117974A (en) 1991-10-02 1995-12-07 Libraries of backbone-cyclized peptidomimetics
US08/569042 1995-12-07
PCT/IL1996/000091 WO1997009344A2 (en) 1995-08-29 1996-08-28 Librairies of backbone-cyclized peptidomimetics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU27711/00A Division AU754476B2 (en) 1995-08-29 2000-04-12 Backbone-cyclized BPI peptidomimetics

Publications (2)

Publication Number Publication Date
AU6836196A AU6836196A (en) 1997-03-27
AU714917B2 true AU714917B2 (en) 2000-01-13

Family

ID=26323124

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68361/96A Ceased AU714917B2 (en) 1995-08-29 1996-08-28 Libraries of backbone-cyclized peptidomimetics

Country Status (6)

Country Link
US (2) US6117974A (esLanguage)
EP (1) EP0923601A2 (esLanguage)
JP (1) JPH11500741A (esLanguage)
AU (1) AU714917B2 (esLanguage)
CA (1) CA2230861A1 (esLanguage)
WO (1) WO1997009344A2 (esLanguage)

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US6407059B1 (en) * 1994-06-08 2002-06-18 Peptor Limited Conformationally constrained backbone cyclized peptide analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
IL122343A0 (en) * 1997-11-27 1998-04-05 Yissum Res Dev Co Inhibition of nuclear import by backbone cyclic peptide analogs
WO1999028339A1 (en) * 1997-12-02 1999-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Backbone cyclic peptide fragments and their analogs derived from pban 1-33, useful as insecticides
EP1037904A2 (en) * 1997-12-15 2000-09-27 Peptor Ltd Branched building units for synthesizing cyclic peptides
US6355616B1 (en) 1999-06-25 2002-03-12 Xoma (Us) Technology Ltd. Derivative compounds derived from or based on bactericidal/permeability-increasing protein
WO2002020610A2 (en) * 2000-09-07 2002-03-14 Biosynthema Inc. Conformationally constrained labeled peptides for imaging and therapy
WO2003059933A2 (en) * 2002-01-03 2003-07-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Conformationally constrained c-backbone cyclic peptides
US20030144260A1 (en) * 2002-01-03 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method
IL148921A0 (en) 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
FR2838444B1 (fr) * 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US7147751B2 (en) * 2002-12-20 2006-12-12 Kimberly-Clark Worldwide, Inc. Wiping products having a low coefficient of friction in the wet state and process for producing same
US6994770B2 (en) * 2002-12-20 2006-02-07 Kimberly-Clark Worldwide, Inc. Strength additives for tissue products
EP1580559B1 (en) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
US20060068661A1 (en) * 2004-09-29 2006-03-30 Kimberly-Clark Worldwide, Inc. Wiping products having a high equilibrium moisture and a low coefficient of friction
US20060211507A1 (en) * 2005-03-21 2006-09-21 Intertex, Inc. Stake for securing inflatable devices
AU2006253733A1 (en) * 2005-05-31 2006-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Backbone cyclized melanocortin stimulating hormone (alpha S ) analogs
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
WO2008053486A1 (en) * 2006-11-02 2008-05-08 Sylvie Luria Methods for screening for therapeutic molecules and use of the molecules therefrom
EP2417150A2 (en) * 2009-04-06 2012-02-15 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011024175A1 (en) 2009-08-28 2011-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
FR2956115B1 (fr) 2010-02-05 2012-04-06 Isp Investments Inc Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
EP2807182A1 (en) 2012-01-23 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2)
US9725484B2 (en) 2013-02-25 2017-08-08 The Regents Of The University Of Michigan Methods and compositions for the treatment of bone remodeling disorders
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
US11141452B2 (en) * 2014-02-24 2021-10-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Bifunctional compounds for relief of pain comprising an opioid receptor agonist moiety and a NK1 receptor antagonist moiety and methods for treating pain
WO2017212477A1 (en) 2016-06-07 2017-12-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88)
EP3684794B1 (en) 2017-09-19 2025-08-06 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Somatostatin prodrugs
WO2020170249A1 (en) 2019-02-21 2020-08-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
WO2025141573A1 (en) 2023-12-27 2025-07-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Calreticulin peptidomimetic inhibitors and prodrugs

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US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
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Also Published As

Publication number Publication date
EP0923601A4 (esLanguage) 1999-06-23
WO1997009344A3 (en) 1997-05-22
CA2230861A1 (en) 1997-03-13
WO1997009344A2 (en) 1997-03-13
EP0923601A2 (en) 1999-06-23
AU6836196A (en) 1997-03-27
US6706862B1 (en) 2004-03-16
JPH11500741A (ja) 1999-01-19
US6117974A (en) 2000-09-12

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