AU714482B2 - Inhibitors of cyclophilin rotamase activity - Google Patents
Inhibitors of cyclophilin rotamase activity Download PDFInfo
- Publication number
- AU714482B2 AU714482B2 AU77210/96A AU7721096A AU714482B2 AU 714482 B2 AU714482 B2 AU 714482B2 AU 77210/96 A AU77210/96 A AU 77210/96A AU 7721096 A AU7721096 A AU 7721096A AU 714482 B2 AU714482 B2 AU 714482B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- neurological
- fluorinated analog
- formula
- fluorinated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56068595A | 1995-11-20 | 1995-11-20 | |
US08/560685 | 1995-11-20 | ||
PCT/US1996/017677 WO1997018828A1 (fr) | 1995-11-20 | 1996-11-15 | Inhibiteurs d'activite de cyclophiline rotamase |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7721096A AU7721096A (en) | 1997-06-11 |
AU714482B2 true AU714482B2 (en) | 2000-01-06 |
Family
ID=24238888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU77210/96A Ceased AU714482B2 (en) | 1995-11-20 | 1996-11-15 | Inhibitors of cyclophilin rotamase activity |
Country Status (18)
Country | Link |
---|---|
US (2) | US6444643B1 (fr) |
EP (1) | EP0880358B1 (fr) |
JP (1) | JP3089350B2 (fr) |
KR (1) | KR19990071482A (fr) |
CN (1) | CN1123360C (fr) |
AT (1) | ATE246510T1 (fr) |
AU (1) | AU714482B2 (fr) |
BR (1) | BR9611624A (fr) |
CA (1) | CA2238050C (fr) |
CZ (1) | CZ154098A3 (fr) |
DE (1) | DE69629392T2 (fr) |
ES (1) | ES2206608T3 (fr) |
LV (1) | LV12125B (fr) |
MX (1) | MX9804011A (fr) |
NO (1) | NO982264L (fr) |
PL (1) | PL327994A1 (fr) |
TR (1) | TR199800890T2 (fr) |
WO (1) | WO1997018828A1 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
AR010744A1 (es) * | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | Inhibidores polipropilos de ciclofilina |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
WO1999010374A1 (fr) * | 1997-08-26 | 1999-03-04 | Wisconsin Alumni Research Foundation | Conjugues de cyclosporine a et utilisations |
US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
USRE40987E1 (en) | 1998-07-01 | 2009-11-17 | Debiopharm S.A. | Cyclosporin with improved activity profile |
US6030825A (en) * | 1998-08-19 | 2000-02-29 | Incyte Pharmaceuticals, Inc. | Cyclophilin-type peptidyl-prolyl cis/trans isomerase |
EP1115412A4 (fr) * | 1998-09-23 | 2004-12-15 | Marcus Keep | Neuro-immunophillines pour radioprotection neuronale selective |
US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
PT1181304E (pt) | 1999-04-08 | 2008-01-23 | Antisoma Res Ltd | Actividade antiproliferativa de oligonucleótidos ricos em g e método de utilização dos mesmos para ligação a nucleolina |
US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
AU7353300A (en) | 1999-09-08 | 2001-04-10 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
US6656971B2 (en) | 2001-01-25 | 2003-12-02 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
US20030068321A1 (en) * | 2001-09-07 | 2003-04-10 | Guilford Pharmaceuticals, Inc. | Methods of effecting neuronal activity |
US20040204340A1 (en) * | 2003-04-11 | 2004-10-14 | Guilford Pharmaceuticals, Inc. | Polyprolyl inhibitors of cyclophilin |
CA2573400A1 (fr) * | 2004-07-13 | 2006-01-19 | Novartis Ag | Cyclosporines permettant de traiter la maladie d'alzheimer |
PT1802650E (pt) * | 2004-10-01 | 2011-12-30 | Scynexis Inc | Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c |
US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
AU2006251832A1 (en) * | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
CN101316859A (zh) * | 2005-09-30 | 2008-12-03 | 西尼克斯公司 | 用于治疗和预防病毒感染的环孢菌素a的芳基烷基和杂芳基烷基衍生物 |
EP2023918B1 (fr) | 2006-05-19 | 2011-03-23 | Scynexis, Inc. | Cyclosporines pour le traitement et la prévention de troubles oculaires |
JP2009539292A (ja) * | 2006-06-02 | 2009-11-12 | ぺリション、クロード、アニー | 活性電子の管理 |
US7576057B2 (en) * | 2006-11-20 | 2009-08-18 | Scynexis, Inc. | Cyclic peptides |
US20080255038A1 (en) * | 2007-04-11 | 2008-10-16 | Samuel Earl Hopkins | Pharmaceutical compositions |
US8394763B2 (en) | 2007-09-26 | 2013-03-12 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
EP2280989B1 (fr) * | 2008-06-06 | 2016-02-10 | Scynexis, Inc. | Analogues de la cyclosporine et leur utilisation dans le traitement d'infections par le vhc |
AU2009276241A1 (en) * | 2008-07-30 | 2010-02-04 | Ciclofilin Pharmaceuticals Corp. | Nonimmunosuppressive cyclosporine analogue molecules |
WO2010074753A1 (fr) * | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs |
WO2010076329A1 (fr) * | 2008-12-31 | 2010-07-08 | Scynexis, Inc. | Dérivés de cyclosporine a |
KR102305423B1 (ko) | 2010-12-15 | 2021-09-27 | 콘트라빌 파마슈티컬스, 인코퍼레이티드 | 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3260468D1 (en) * | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
EP0194972B1 (fr) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Cyclosporines |
US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
US4885276A (en) * | 1987-06-03 | 1989-12-05 | Merck & Co., Inc. | Cyclosporin analogs with modified "C-9 amino acids" |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
DE3851268T2 (de) * | 1987-06-19 | 1995-01-26 | Sandoz Ag | Zyklische Peptolide. |
US4914188A (en) * | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5284826A (en) * | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
ES2095926T5 (es) * | 1990-11-02 | 2001-02-16 | Novartis Ag | Cyclosporins. |
US5321009A (en) | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5898029A (en) | 1994-04-12 | 1999-04-27 | The John Hopkins University | Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
-
1996
- 1996-05-02 JP JP08111414A patent/JP3089350B2/ja not_active Expired - Fee Related
- 1996-11-15 PL PL96327994A patent/PL327994A1/xx unknown
- 1996-11-15 CA CA2238050A patent/CA2238050C/fr not_active Expired - Fee Related
- 1996-11-15 DE DE69629392T patent/DE69629392T2/de not_active Expired - Lifetime
- 1996-11-15 BR BR9611624A patent/BR9611624A/pt not_active Application Discontinuation
- 1996-11-15 ES ES96940289T patent/ES2206608T3/es not_active Expired - Lifetime
- 1996-11-15 EP EP96940289A patent/EP0880358B1/fr not_active Expired - Lifetime
- 1996-11-15 TR TR1998/00890T patent/TR199800890T2/xx unknown
- 1996-11-15 AT AT96940289T patent/ATE246510T1/de not_active IP Right Cessation
- 1996-11-15 CZ CZ981540A patent/CZ154098A3/cs unknown
- 1996-11-15 KR KR1019980703753A patent/KR19990071482A/ko not_active Application Discontinuation
- 1996-11-15 AU AU77210/96A patent/AU714482B2/en not_active Ceased
- 1996-11-15 CN CN96199455A patent/CN1123360C/zh not_active Expired - Fee Related
- 1996-11-15 WO PCT/US1996/017677 patent/WO1997018828A1/fr not_active Application Discontinuation
-
1998
- 1998-05-18 NO NO982264A patent/NO982264L/no not_active Application Discontinuation
- 1998-05-20 MX MX9804011A patent/MX9804011A/es unknown
- 1998-07-16 LV LVP-98-114A patent/LV12125B/en unknown
-
1999
- 1999-05-28 US US09/321,762 patent/US6444643B1/en not_active Expired - Lifetime
-
2002
- 2002-07-22 US US10/199,107 patent/US20030013645A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR19990071482A (ko) | 1999-09-27 |
JPH09143198A (ja) | 1997-06-03 |
AU7721096A (en) | 1997-06-11 |
ES2206608T3 (es) | 2004-05-16 |
CZ154098A3 (cs) | 1998-12-16 |
LV12125A (lv) | 1998-09-20 |
MX9804011A (es) | 1998-09-30 |
PL327994A1 (en) | 1999-01-04 |
EP0880358B1 (fr) | 2003-08-06 |
US6444643B1 (en) | 2002-09-03 |
EP0880358A4 (fr) | 2001-04-18 |
CA2238050A1 (fr) | 1997-05-29 |
WO1997018828A1 (fr) | 1997-05-29 |
CA2238050C (fr) | 2010-09-28 |
DE69629392T2 (de) | 2004-06-24 |
TR199800890T2 (xx) | 1998-08-21 |
NO982264L (no) | 1998-07-20 |
JP3089350B2 (ja) | 2000-09-18 |
CN1123360C (zh) | 2003-10-08 |
CN1207043A (zh) | 1999-02-03 |
NO982264D0 (no) | 1998-05-18 |
ATE246510T1 (de) | 2003-08-15 |
BR9611624A (pt) | 1999-06-01 |
EP0880358A1 (fr) | 1998-12-02 |
US20030013645A1 (en) | 2003-01-16 |
LV12125B (en) | 1998-12-20 |
DE69629392D1 (de) | 2003-09-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |