AU714482B2 - Inhibitors of cyclophilin rotamase activity - Google Patents

Inhibitors of cyclophilin rotamase activity Download PDF

Info

Publication number
AU714482B2
AU714482B2 AU77210/96A AU7721096A AU714482B2 AU 714482 B2 AU714482 B2 AU 714482B2 AU 77210/96 A AU77210/96 A AU 77210/96A AU 7721096 A AU7721096 A AU 7721096A AU 714482 B2 AU714482 B2 AU 714482B2
Authority
AU
Australia
Prior art keywords
alkyl
neurological
fluorinated analog
formula
fluorinated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU77210/96A
Other languages
English (en)
Other versions
AU7721096A (en
Inventor
Gregory S. Hamilton
Solomon H. Snyder
Joseph P. Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
School of Medicine of Johns Hopkins University
Original Assignee
Guilford Pharmaceuticals Inc
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc, Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Guilford Pharmaceuticals Inc
Publication of AU7721096A publication Critical patent/AU7721096A/en
Application granted granted Critical
Publication of AU714482B2 publication Critical patent/AU714482B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
AU77210/96A 1995-11-20 1996-11-15 Inhibitors of cyclophilin rotamase activity Ceased AU714482B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56068595A 1995-11-20 1995-11-20
US08/560685 1995-11-20
PCT/US1996/017677 WO1997018828A1 (fr) 1995-11-20 1996-11-15 Inhibiteurs d'activite de cyclophiline rotamase

Publications (2)

Publication Number Publication Date
AU7721096A AU7721096A (en) 1997-06-11
AU714482B2 true AU714482B2 (en) 2000-01-06

Family

ID=24238888

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77210/96A Ceased AU714482B2 (en) 1995-11-20 1996-11-15 Inhibitors of cyclophilin rotamase activity

Country Status (18)

Country Link
US (2) US6444643B1 (fr)
EP (1) EP0880358B1 (fr)
JP (1) JP3089350B2 (fr)
KR (1) KR19990071482A (fr)
CN (1) CN1123360C (fr)
AT (1) ATE246510T1 (fr)
AU (1) AU714482B2 (fr)
BR (1) BR9611624A (fr)
CA (1) CA2238050C (fr)
CZ (1) CZ154098A3 (fr)
DE (1) DE69629392T2 (fr)
ES (1) ES2206608T3 (fr)
LV (1) LV12125B (fr)
MX (1) MX9804011A (fr)
NO (1) NO982264L (fr)
PL (1) PL327994A1 (fr)
TR (1) TR199800890T2 (fr)
WO (1) WO1997018828A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
AR010744A1 (es) * 1996-12-09 2000-07-12 Guildford Pharmaceuticals Inc Inhibidores polipropilos de ciclofilina
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
WO1999010373A1 (fr) * 1997-08-26 1999-03-04 Wisconsin Alumni Research Foundation Cyclosporines non immunosuppressives et utilisation de ces cyclosporines pour prevenir et traiter une infection par le vih
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
JP4350898B2 (ja) * 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン
US6030825A (en) * 1998-08-19 2000-02-29 Incyte Pharmaceuticals, Inc. Cyclophilin-type peptidyl-prolyl cis/trans isomerase
CA2345378A1 (fr) * 1998-09-23 2000-03-30 Marcus Keep Neuro-immunophillines pour radioprotection neuronale selective
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (fr) 1999-04-08 2007-10-10 Antisoma Research Limited Procede inhibant la proliferation d'oligonucleotides riches en guanosine et procede de liaison desdits oligonucleotides a la nucleoline
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
AU7353300A (en) 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
US6593362B2 (en) 2001-05-21 2003-07-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US20030068321A1 (en) * 2001-09-07 2003-04-10 Guilford Pharmaceuticals, Inc. Methods of effecting neuronal activity
US20040204340A1 (en) * 2003-04-11 2004-10-14 Guilford Pharmaceuticals, Inc. Polyprolyl inhibitors of cyclophilin
CN1984670A (zh) * 2004-07-13 2007-06-20 诺瓦提斯公司 治疗阿尔茨海默病的环孢菌素
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
RU2399628C2 (ru) * 2004-10-01 2010-09-20 Скайнексис, Инк. Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с
JP2008545663A (ja) * 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
WO2007041631A1 (fr) * 2005-09-30 2007-04-12 Scynexis, Inc. Derives d'arylalkyle et d'heteroarylalkyle de cyclosporine a utilises pour traiter et prevenir une infection virale
CN101511357B (zh) 2006-05-19 2011-11-02 西尼克斯公司 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
WO2008069917A2 (fr) * 2006-11-20 2008-06-12 Scynexis, Inc. Nouveaux peptides cycliques
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
US8394763B2 (en) 2007-09-26 2013-03-12 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2010002428A2 (fr) * 2008-06-06 2010-01-07 Scynexis, Inc. Nouveaux peptides macrocycliques
US20130190223A1 (en) * 2008-07-30 2013-07-25 Isotechnika Pharma Inc. Nonimmunosuppressive cyclosporine analogue molecules
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN102307892A (zh) * 2008-12-31 2012-01-04 西尼克斯公司 环孢菌素a的衍生物
MX353720B (es) 2010-12-15 2018-01-25 Contravir Pharmaceuticals Inc Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056782B1 (fr) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporines
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US4885276A (en) * 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
EP0296123B1 (fr) * 1987-06-19 1994-08-31 Sandoz Ag Peptolides cycliques
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5284826A (en) * 1989-07-24 1994-02-08 Sandoz Ltd. 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5385915A (en) * 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
EP0484281B2 (fr) * 1990-11-02 2000-11-22 Novartis AG Cyclosporines
US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
US5898029A (en) 1994-04-12 1999-04-27 The John Hopkins University Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤

Also Published As

Publication number Publication date
LV12125A (lv) 1998-09-20
EP0880358B1 (fr) 2003-08-06
PL327994A1 (en) 1999-01-04
ATE246510T1 (de) 2003-08-15
LV12125B (en) 1998-12-20
EP0880358A1 (fr) 1998-12-02
EP0880358A4 (fr) 2001-04-18
US20030013645A1 (en) 2003-01-16
ES2206608T3 (es) 2004-05-16
KR19990071482A (ko) 1999-09-27
CZ154098A3 (cs) 1998-12-16
TR199800890T2 (xx) 1998-08-21
JPH09143198A (ja) 1997-06-03
US6444643B1 (en) 2002-09-03
CN1207043A (zh) 1999-02-03
MX9804011A (es) 1998-09-30
AU7721096A (en) 1997-06-11
BR9611624A (pt) 1999-06-01
NO982264L (no) 1998-07-20
NO982264D0 (no) 1998-05-18
CN1123360C (zh) 2003-10-08
CA2238050A1 (fr) 1997-05-29
CA2238050C (fr) 2010-09-28
JP3089350B2 (ja) 2000-09-18
DE69629392T2 (de) 2004-06-24
DE69629392D1 (de) 2003-09-11
WO1997018828A1 (fr) 1997-05-29

Similar Documents

Publication Publication Date Title
AU714482B2 (en) Inhibitors of cyclophilin rotamase activity
US6245783B1 (en) Method of using neurotrophic sulfonamide compounds
US5801197A (en) Rotamase enzyme activity inhibitors
IL128675A (en) The heterocyclic compounds containing a large number of trautomas transformed with esters and amides, pharmaceutical preparations containing them and their use
EP0777478A1 (fr) Inhibiteurs de l'activite enzymatique de la rotamase
WO1996040140A9 (fr) Inhibiteurs de l'activite enzymatique de la rotamase
PL194249B1 (pl) Heterocykliczne ketony, kompozycje farmaceutycznezawierające heterocykliczne ketony oraz zastosowanie heterocyklicznych ketonów
CA2281096A1 (fr) Methode d'utilisation de carbamates et d'urees neurotrophiques
US6242468B1 (en) Carbamate and urea compositions and neurotrophic uses
US20020013344A1 (en) Rotamas enzyme activity inhibitors
AU713302C (en) Rotamase enzyme activity inhibitors
MXPA98003356A (en) Inhibitors of the activity of enzima rotam
MXPA99007384A (en) Method of using neutrophic sulfonamide compounds

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)