AU705528B2 - Method of detecting lung disease - Google Patents
Method of detecting lung disease Download PDFInfo
- Publication number
- AU705528B2 AU705528B2 AU66399/96A AU6639996A AU705528B2 AU 705528 B2 AU705528 B2 AU 705528B2 AU 66399/96 A AU66399/96 A AU 66399/96A AU 6639996 A AU6639996 A AU 6639996A AU 705528 B2 AU705528 B2 AU 705528B2
- Authority
- AU
- Australia
- Prior art keywords
- lung
- acceptable salt
- subject
- pharmaceutically acceptable
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/509,052 US5628984A (en) | 1995-07-31 | 1995-07-31 | Method of detecting lung disease |
| US08/509052 | 1995-07-31 | ||
| PCT/US1996/012377 WO1997005195A1 (en) | 1995-07-31 | 1996-07-24 | Method of detecting lung disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6639996A AU6639996A (en) | 1997-02-26 |
| AU705528B2 true AU705528B2 (en) | 1999-05-27 |
Family
ID=24025091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU66399/96A Ceased AU705528B2 (en) | 1995-07-31 | 1996-07-24 | Method of detecting lung disease |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US5628984A (Direct) |
| EP (1) | EP0841900B1 (Direct) |
| JP (2) | JP3623237B2 (Direct) |
| KR (1) | KR100283306B1 (Direct) |
| CN (1) | CN1121441C (Direct) |
| AT (1) | ATE276740T1 (Direct) |
| AU (1) | AU705528B2 (Direct) |
| BR (1) | BR9610059A (Direct) |
| CA (1) | CA2226892A1 (Direct) |
| DE (1) | DE69633449T2 (Direct) |
| ES (1) | ES2229281T3 (Direct) |
| IL (1) | IL122803A0 (Direct) |
| MX (1) | MX9800933A (Direct) |
| NO (1) | NO980279L (Direct) |
| NZ (1) | NZ313864A (Direct) |
| WO (1) | WO1997005195A1 (Direct) |
| ZA (1) | ZA966425B (Direct) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2961709B2 (ja) * | 1995-04-13 | 1999-10-12 | ミルカウス ラボラトリー， インコーポレイテッド | 呼吸器系疾患の治療方法および治療用薬剤組成物 |
| US5948768A (en) * | 1995-04-13 | 1999-09-07 | Milkhaus Laboratory | Treatment of otitis media by sublingual administration of DNA |
| US6096721A (en) * | 1995-04-13 | 2000-08-01 | Milkhaus Laboratory, Inc. | Method for treating mucositis by sublingual administration of DNA |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5968913A (en) * | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6159952A (en) * | 1996-11-07 | 2000-12-12 | Inspire Pharmaceuticals, Inc. | Method of treating bronchitis with uridine triphosphate and related compounds |
| US6998121B2 (en) | 2003-01-23 | 2006-02-14 | Milkhaus Laboratory, Inc. | Method of treatment of connective tissue disorders by administration of streptolysin O |
| TW593331B (en) * | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| US6872710B2 (en) * | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| BRPI9810436B1 (pt) | 1997-07-25 | 2015-12-29 | Inspire Pharmaceuticals Inc | processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo |
| KR20010023359A (ko) * | 1997-08-29 | 2001-03-26 | 인스파이어 파마슈티컬즈 | 폐질환 치료용 우리딘 5'-디포스페이트 및 그의 유사체의용도 |
| US6926911B1 (en) * | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| EP1139746A4 (en) * | 1998-12-22 | 2003-09-17 | Univ North Carolina | CONNECTIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISEASES AND THE ADMINISTRATION OF MEDICINAL SUBSTANCES |
| JP2002537329A (ja) | 1999-02-26 | 2002-11-05 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 特定のウリジン、アデニン及びシチジン二リン酸並びにそれらの類似体による粘膜水和の促進方法 |
| EP1190249A2 (en) * | 1999-06-08 | 2002-03-27 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
| US7241447B1 (en) * | 1999-10-07 | 2007-07-10 | University Of Iowa Research Foundation | Adeno-associated virus vectors and uses thereof |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| JP2005508297A (ja) | 2001-06-25 | 2005-03-31 | インスパイアー ファーマシューティカルズ，インコーポレイティド | Ｐ２ｙプリン受容体作用物質による関節潤滑 |
| JP3823162B2 (ja) * | 2001-07-31 | 2006-09-20 | 株式会社エイアンドティー | 臨床検査分析装置、臨床検査分析方法および臨床検査分析プログラム |
| TW200300692A (en) * | 2001-11-06 | 2003-06-16 | Inspire Pharmaceuticals Inc | Method for treating or preventing inflammatory diseases |
| US20060196365A1 (en) * | 2001-12-11 | 2006-09-07 | Garman Michael H | Combined water cooler and hot beverage maker |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7435724B2 (en) | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| US20050220720A1 (en) * | 2002-05-02 | 2005-10-06 | David Edwards | Formulations limiting spread of pulmonary infections |
| WO2003092654A1 (en) | 2002-05-02 | 2003-11-13 | President And Fellows Of Harvard College | Formulations limiting spread of pulmonary infections |
| US7629312B2 (en) | 2003-01-23 | 2009-12-08 | Milkhaus Laboratory, Inc. | Method of treatment of tendonitis by administration of streptolysin O |
| AU2004227358B8 (en) * | 2003-03-31 | 2009-12-10 | Targeted Genetics Corporation | Compounds and methods to enhance rAAV transduction |
| EP2617709B8 (en) | 2003-06-26 | 2022-12-21 | Biotron Limited | Guanidine derivatives as antiviral agents |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| WO2005051296A2 (en) * | 2003-11-24 | 2005-06-09 | University Of North Carolina At Chapel Hill | Fused ring dicationic anti-protozoan agents and their prodrugs |
| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| US20070276020A1 (en) * | 2004-03-08 | 2007-11-29 | Boykin David W | Dicationic Compounds For Activity Against Trichomonas Vaginalis |
| US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
| GB0417886D0 (en) * | 2004-08-11 | 2004-09-15 | Univ Cardiff | Method and means for enhanced pulmonary delivery |
| US20060199768A1 (en) * | 2005-03-07 | 2006-09-07 | University Of North Carolina At Chapel Hill | Inhibitors of RecA activities for control of antibiotic-resistant bacterial pathogens |
| AU2006201739A1 (en) * | 2005-05-05 | 2006-11-23 | The University Of North Carolina At Chapel Hill | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles |
| EP2402001A1 (en) * | 2005-05-18 | 2012-01-04 | Pulmatrix, Inc. | Formulations for alteration of biophysical properties of mucosal lining |
| US7964619B2 (en) | 2005-06-03 | 2011-06-21 | The University Of North Carolina At Chapel Hill | Teraryl components as antiparasitic agents |
| AU2006202083A1 (en) | 2005-06-03 | 2006-12-21 | Reto Brun | Linear dicationic terphenyls and their aza analogues as antiparasitic agents |
| US20100249175A1 (en) * | 2005-12-02 | 2010-09-30 | Wilson W David | Dicationic compounds which selectively recognize G-quadruplex DNA |
| JP2009535034A (ja) * | 2006-04-28 | 2009-10-01 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | 哺乳動物細胞のパルボウイルス形質導入を調節若しくはウイルス感染を変えるための方法および化合物、ウイルス受容体若しくは共受容体の同定方法 |
| US20080260863A1 (en) * | 2007-04-20 | 2008-10-23 | Pre Holding, Inc. | Compositions for mucociliary clearance and methods for administering same |
| AU2008266856A1 (en) | 2007-06-18 | 2008-12-24 | University Of Louisville Research Foundation, Inc. | Family of PFKFB3 inhibitors with anti-neoplastic activities |
| US20100280098A1 (en) * | 2007-10-05 | 2010-11-04 | Juliano Rudolph L | Receptor targeted oligonucleotides |
| AU2008310734B2 (en) | 2007-10-10 | 2014-06-05 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| US20100331368A1 (en) * | 2007-10-17 | 2010-12-30 | Tidwell Richard R | 2,5-diaryl selenophene compounds, aza 2,5-diaryl thiophene compounds, and their prodrugs as antiprotozoal agents |
| AU2009234156A1 (en) | 2008-04-09 | 2009-10-15 | The University Of North Carolina At Chapel Hill | Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation |
| US20110224221A1 (en) * | 2008-10-01 | 2011-09-15 | Sharpless Norman E | Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors |
| EP2341911A4 (en) * | 2008-10-01 | 2012-10-24 | Univ North Carolina | HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE INHIBITORS OF KINASES DEPENDENT ON CYCLINES 4/6 |
| AU2010229668C1 (en) | 2009-03-26 | 2016-09-15 | Pulmatrix Operating Co., Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| AU2010248886A1 (en) | 2009-05-13 | 2011-12-01 | The University Of North Carolina At Chapel Hill | Cyclin dependent kinase inhibitors and methods of use |
| EP2454227B1 (en) | 2009-07-13 | 2020-08-19 | Patheon API Services Inc. | Synthesis of prostanoids |
| WO2011011783A1 (en) | 2009-07-24 | 2011-01-27 | University Of Tennessee Research Foundation | Spectinamides as anti-tuberculosis agents |
| US8394355B2 (en) * | 2009-08-10 | 2013-03-12 | P2 Science Aps | Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow |
| JP5922111B2 (ja) * | 2010-06-23 | 2016-05-24 | ピーツー−サイエンス・エペイエス | 充血剤注入と同時に血圧測定を行う診断目的の動脈用複合カテーテル |
| WO2012030664A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| EP2448571B1 (en) | 2010-08-30 | 2013-06-12 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| EP2621484A1 (en) | 2010-09-29 | 2013-08-07 | Pulmatrix, Inc. | Monovalent metal cation dry powders for inhalation |
| WO2012050945A1 (en) | 2010-09-29 | 2012-04-19 | Pulmatrix, Inc. | Cationic dry powders |
| AU2011329763A1 (en) | 2010-11-17 | 2013-05-09 | Brigham And Women's Hospital | Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6 |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | PROCESSING METHODS |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| EP2819672A1 (en) | 2012-02-29 | 2015-01-07 | Pulmatrix, Inc. | Inhalable dry powders |
| US9833207B2 (en) | 2012-08-08 | 2017-12-05 | William Harrison Zurn | Analysis and clearing module, system and method |
| JP6392242B2 (ja) | 2012-12-17 | 2018-09-19 | パリオン・サイエンシィズ・インコーポレーテッド | 粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体 |
| MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
| US9962533B2 (en) | 2013-02-14 | 2018-05-08 | William Harrison Zurn | Module for treatment of medical conditions; system for making module and methods of making module |
| SI2968290T1 (sl) | 2013-03-15 | 2020-02-28 | G1 Therapeutics, Inc., | Prehodna zaščita normalnih celic med kemoterapijo |
| EP2967050A4 (en) | 2013-03-15 | 2016-09-28 | G1 Therapeutics Inc | HIGH-ACTIVE ANTINEOPLASTIC AND ANTIPROLIFERATIVE AGENTS |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| KR102311896B1 (ko) | 2013-09-30 | 2021-10-14 | 패턴 에이피아이 서비시즈 인코포레이티드 | 복분해를 사용하는 프로스타글란딘 및 프로스타글란딘 중간체의 합성 경로 |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US9717735B2 (en) | 2014-04-17 | 2017-08-01 | G1 Therapeutics, Inc. | Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| CN104306028B (zh) * | 2014-09-26 | 2016-08-17 | 张清玲 | 一种用于呼吸道细菌16S rRNA基因序列检测的痰液收集方法 |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| US11702672B2 (en) | 2016-02-08 | 2023-07-18 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| US11684679B2 (en) | 2016-03-07 | 2023-06-27 | University Of Iowa Research Foundation | AAV-mediated expression using a synthetic promoter and enhancer |
| WO2017205739A1 (en) | 2016-05-26 | 2017-11-30 | University Of Iowa Research Foundation | cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1 |
| BR112018077136A2 (pt) | 2016-07-01 | 2019-04-30 | G1 Therapeutics, Inc. | composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis. |
| US10413583B2 (en) | 2016-11-30 | 2019-09-17 | The University Of Chicago | Synthetic substrates for enzymes that catalyze reactions of modified cysteines and related methods |
| WO2018132747A1 (en) | 2017-01-13 | 2018-07-19 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding rna and uses thereof |
| WO2018160889A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceuticals, Inc. | Aryl, heteroary, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| WO2019028284A1 (en) | 2017-08-02 | 2019-02-07 | Achillion Pharmaceuticals, Inc. | THERAPEUTIC REGIMES FOR THE TREATMENT OF NOCTURNAL PAROXYSTIC HEMOGLOBINURIA |
| GB2604314A (en) * | 2017-09-22 | 2022-09-07 | Nerudia Ltd | Device, system and method |
| US11439608B2 (en) | 2017-09-25 | 2022-09-13 | Qun Lu | Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease |
| WO2019113210A1 (en) | 2017-12-05 | 2019-06-13 | Anthos Partners, Lp | Phosphonium-based ionic drug conjugates |
| MX2021002640A (es) | 2018-09-06 | 2021-07-16 | Achillion Pharmaceuticals Inc | Formas morficas de los inhibidores del factor d del complemento. |
| WO2020051532A2 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| AU2019346464A1 (en) | 2018-09-25 | 2021-04-08 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor D inhibitors |
| CA3123583A1 (en) | 2018-12-17 | 2020-06-25 | Achillion Pharmaceuticals, Inc. | Targeted dosing for the treatment of complement mediated disorders |
| BR112021018456A2 (pt) | 2019-03-22 | 2021-11-23 | Achillion Pharmaceuticals Inc | Compostos farmacêuticos para o tratamento de distúrbios mediados por complemento |
| CN120865218A (zh) | 2020-05-19 | 2025-10-31 | 法码科思莫斯有限公司 | 用于治疗医学病症的细胞周期蛋白依赖性激酶抑制化合物 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1055465A (en) * | 1962-09-27 | 1967-01-18 | Vantorex Ltd | Allergenic aerosol compositions |
| NL299931A (Direct) * | 1962-10-30 | |||
| US4132600A (en) * | 1977-06-01 | 1979-01-02 | Massachusetts Institute Of Technology | Enzymatic noninvasive method for detecting cancer |
| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| FR2571257A1 (fr) * | 1984-08-06 | 1986-04-11 | Gros Pierre | Composition destinee a l'humidification de la muqueuse rhino-pharyngee |
| US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| US4950477A (en) * | 1988-08-23 | 1990-08-21 | Memorial Hospital For Cancer And Allied Dieseas | Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes |
| GB9027968D0 (en) * | 1990-12-22 | 1991-02-13 | Fisons Plc | Method of treatment |
| EP0517573A1 (fr) * | 1991-06-05 | 1992-12-09 | Synthelabo | Compositions pharmaceutiques pour le traitement des affections des voies respiratoires |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5567689A (en) * | 1993-08-13 | 1996-10-22 | The Uab Research Foundation | Methods for increasing uridine levels with L-nucleosides |
| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
-
1995
- 1995-07-31 US US08/509,052 patent/US5628984A/en not_active Expired - Lifetime
-
1996
- 1996-07-24 CN CN96195803A patent/CN1121441C/zh not_active Expired - Fee Related
- 1996-07-24 KR KR1019980700675A patent/KR100283306B1/ko not_active Expired - Fee Related
- 1996-07-24 NZ NZ313864A patent/NZ313864A/xx unknown
- 1996-07-24 IL IL12280396A patent/IL122803A0/xx unknown
- 1996-07-24 ES ES96926158T patent/ES2229281T3/es not_active Expired - Lifetime
- 1996-07-24 CA CA002226892A patent/CA2226892A1/en not_active Abandoned
- 1996-07-24 JP JP50781797A patent/JP3623237B2/ja not_active Expired - Fee Related
- 1996-07-24 MX MX9800933A patent/MX9800933A/es not_active IP Right Cessation
- 1996-07-24 BR BR9610059A patent/BR9610059A/pt not_active Application Discontinuation
- 1996-07-24 US US08/776,772 patent/US6133247A/en not_active Expired - Lifetime
- 1996-07-24 AU AU66399/96A patent/AU705528B2/en not_active Ceased
- 1996-07-24 WO PCT/US1996/012377 patent/WO1997005195A1/en not_active Ceased
- 1996-07-24 AT AT96926158T patent/ATE276740T1/de not_active IP Right Cessation
- 1996-07-24 EP EP96926158A patent/EP0841900B1/en not_active Expired - Lifetime
- 1996-07-24 DE DE69633449T patent/DE69633449T2/de not_active Expired - Fee Related
- 1996-07-29 ZA ZA9606425A patent/ZA966425B/xx unknown
- 1996-12-30 US US08/777,026 patent/US5902567A/en not_active Expired - Lifetime
-
1998
- 1998-01-21 NO NO980279A patent/NO980279L/no not_active Application Discontinuation
-
1999
- 1999-11-04 US US09/433,757 patent/US6214536B1/en not_active Expired - Lifetime
-
2002
- 2002-08-05 JP JP2002227140A patent/JP2003073280A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69633449D1 (de) | 2004-10-28 |
| US6214536B1 (en) | 2001-04-10 |
| MX9800933A (es) | 1998-05-31 |
| US5628984A (en) | 1997-05-13 |
| ZA966425B (en) | 1997-02-19 |
| CN1121441C (zh) | 2003-09-17 |
| IL122803A0 (en) | 1998-09-16 |
| BR9610059A (pt) | 1999-03-02 |
| AU6639996A (en) | 1997-02-26 |
| US6133247A (en) | 2000-10-17 |
| EP0841900A1 (en) | 1998-05-20 |
| JP2003073280A (ja) | 2003-03-12 |
| NO980279D0 (no) | 1998-01-21 |
| NO980279L (no) | 1998-01-21 |
| EP0841900A4 (Direct) | 1998-06-10 |
| EP0841900B1 (en) | 2004-09-22 |
| ES2229281T3 (es) | 2005-04-16 |
| US5902567A (en) | 1999-05-11 |
| DE69633449T2 (de) | 2006-04-27 |
| CA2226892A1 (en) | 1997-02-13 |
| WO1997005195A1 (en) | 1997-02-13 |
| ATE276740T1 (de) | 2004-10-15 |
| CN1191553A (zh) | 1998-08-26 |
| JPH11509759A (ja) | 1999-08-31 |
| KR100283306B1 (ko) | 2001-03-02 |
| JP3623237B2 (ja) | 2005-02-23 |
| KR19990036011A (ko) | 1999-05-25 |
| NZ313864A (en) | 2000-04-28 |
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