AU662960B2 - N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors - Google Patents

N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors Download PDF

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Publication number
AU662960B2
AU662960B2 AU35043/93A AU3504393A AU662960B2 AU 662960 B2 AU662960 B2 AU 662960B2 AU 35043/93 A AU35043/93 A AU 35043/93A AU 3504393 A AU3504393 A AU 3504393A AU 662960 B2 AU662960 B2 AU 662960B2
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substituted
alkyl
group
compound
formula
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AU35043/93A
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AU3504393A (en
Inventor
Loic Foulon
Georges Garcia
Dino Nisato
Richard Roux
Claudine Serradeil-Le Gal
Gerard Valette
Jean Wagnon
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Elf Sanofi SA
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Elf Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU35043/93A 1992-01-30 1993-01-28 N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors Ceased AU662960B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9201034 1992-01-30
FR9201034A FR2686878B1 (fr) 1992-01-30 1992-01-30 Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant.
PCT/FR1993/000093 WO1993015051A1 (fr) 1992-01-30 1993-01-28 Derives du n-sulfonyl-2-oxoindole ayant une affinite pour les recepteurs de la vasopressine et/ou de l'ocytocine

Publications (2)

Publication Number Publication Date
AU3504393A AU3504393A (en) 1993-09-01
AU662960B2 true AU662960B2 (en) 1995-09-21

Family

ID=9426168

Family Applications (1)

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AU35043/93A Ceased AU662960B2 (en) 1992-01-30 1993-01-28 N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors

Country Status (20)

Country Link
EP (1) EP0581939B1 (enrdf_load_stackoverflow)
JP (1) JPH06507182A (enrdf_load_stackoverflow)
AT (1) ATE180773T1 (enrdf_load_stackoverflow)
AU (1) AU662960B2 (enrdf_load_stackoverflow)
BR (1) BR9303993A (enrdf_load_stackoverflow)
CA (1) CA2107348A1 (enrdf_load_stackoverflow)
CZ (1) CZ203793A3 (enrdf_load_stackoverflow)
DE (1) DE69325130D1 (enrdf_load_stackoverflow)
FI (2) FI980341A7 (enrdf_load_stackoverflow)
FR (1) FR2686878B1 (enrdf_load_stackoverflow)
HU (1) HUT68642A (enrdf_load_stackoverflow)
IL (1) IL104559A0 (enrdf_load_stackoverflow)
MX (1) MX9300498A (enrdf_load_stackoverflow)
NO (1) NO180538C (enrdf_load_stackoverflow)
NZ (1) NZ249158A (enrdf_load_stackoverflow)
RU (1) RU2135469C1 (enrdf_load_stackoverflow)
SK (1) SK105393A3 (enrdf_load_stackoverflow)
TW (1) TW239126B (enrdf_load_stackoverflow)
WO (1) WO1993015051A1 (enrdf_load_stackoverflow)
ZA (1) ZA93649B (enrdf_load_stackoverflow)

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Also Published As

Publication number Publication date
AU3504393A (en) 1993-09-01
WO1993015051A1 (fr) 1993-08-05
NZ249158A (en) 1996-02-27
TW239126B (enrdf_load_stackoverflow) 1995-01-21
NO933482D0 (no) 1993-09-29
EP0581939B1 (fr) 1999-06-02
ZA93649B (en) 1993-09-02
JPH06507182A (ja) 1994-08-11
BR9303993A (pt) 1994-08-02
EP0581939A1 (fr) 1994-02-09
FI934274L (fi) 1993-09-29
NO933482L (no) 1993-11-29
FI980341A0 (fi) 1998-02-13
RU2135469C1 (ru) 1999-08-27
FR2686878A1 (fr) 1993-08-06
IL104559A0 (en) 1993-05-13
FI934274A0 (fi) 1993-09-29
CA2107348A1 (en) 1993-07-31
HU9302762D0 (en) 1993-12-28
NO180538C (no) 1997-05-07
FI980341L (fi) 1998-02-13
CZ203793A3 (en) 1994-04-13
HUT68642A (en) 1995-07-28
ATE180773T1 (de) 1999-06-15
MX9300498A (es) 1994-07-29
NO180538B (no) 1997-01-27
DE69325130D1 (de) 1999-07-08
SK105393A3 (en) 1994-08-10
FI980341A7 (fi) 1998-02-13
FR2686878B1 (fr) 1995-06-30
FI934274A7 (fi) 1993-09-29

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