AU634517B2 - Somatotropin analogs - Google Patents

Somatotropin analogs

Info

Publication number
AU634517B2
AU634517B2 AU49427/90A AU4942790A AU634517B2 AU 634517 B2 AU634517 B2 AU 634517B2 AU 49427/90 A AU49427/90 A AU 49427/90A AU 4942790 A AU4942790 A AU 4942790A AU 634517 B2 AU634517 B2 AU 634517B2
Authority
AU
Australia
Prior art keywords
rbst
somatotropin
animal
asparagine
serine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49427/90A
Other languages
English (en)
Other versions
AU4942790A (en
Inventor
Robert L. Garlick
Stephen B. Lyle
John E. Mott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU4942790A publication Critical patent/AU4942790A/en
Application granted granted Critical
Publication of AU634517B2 publication Critical patent/AU634517B2/en
Assigned to PHARMACIA & UPJOHN COMPANY reassignment PHARMACIA & UPJOHN COMPANY Request to Amend Deed and Register Assignors: UPJOHN COMPANY, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
AU49427/90A 1989-01-19 1989-12-11 Somatotropin analogs Ceased AU634517B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29910789A 1989-01-19 1989-01-19
US299107 2002-11-18

Publications (2)

Publication Number Publication Date
AU4942790A AU4942790A (en) 1990-08-13
AU634517B2 true AU634517B2 (en) 1993-02-25

Family

ID=23153338

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49427/90A Ceased AU634517B2 (en) 1989-01-19 1989-12-11 Somatotropin analogs

Country Status (7)

Country Link
EP (1) EP0454730A1 (de)
JP (1) JPH04502762A (de)
KR (1) KR910700264A (de)
AU (1) AU634517B2 (de)
CA (1) CA2005358A1 (de)
DK (1) DK136991D0 (de)
WO (1) WO1990008164A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929273T2 (de) * 1988-08-24 2001-07-05 American Cyanamid Co Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
ZA936811B (en) * 1992-10-28 1995-03-15 Upjohn Co Somatotropin modifications
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
BRPI0408358A (pt) 2003-03-14 2006-03-21 Neose Technologies Inc polìmeros hidrossolúveis ramificados e seus conjugados
EP2338333B1 (de) 2003-04-09 2017-09-06 ratiopharm GmbH Glycopegylierungsverfahren und durch die Verfahren hergestellte Proteine/Peptide
ES2380093T3 (es) * 2003-05-09 2012-05-08 Biogenerix Ag Composiciones y métodos para la preparación de mutantes de glucosilación de la hormona del crecimiento humana
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
AU2005206796B2 (en) 2004-01-08 2011-06-16 Ratiopharm Gmbh O-linked glycosylation of peptides
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1799249A2 (de) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegyliertes interferon alpha
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
EP2514757A3 (de) 2005-01-10 2014-03-05 ratiopharm GmbH Glycopegylierter Granulozyten-Kolonie stimulierende Faktor
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1888098A2 (de) 2005-05-25 2008-02-20 Neose Technologies, Inc. Glykopegylierte erythropoetin-formulierungen
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
WO2008011633A2 (en) 2006-07-21 2008-01-24 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
JP5876649B2 (ja) 2007-06-12 2016-03-02 ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ ヌクレオチド糖の改良製造法
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
WO2009108806A1 (en) 2008-02-27 2009-09-03 Novo Nordisk A/S Conjugated factor viii molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001708A2 (en) * 1985-09-18 1987-03-26 The Upjohn Company Enhanced bioactivity of mammalian somatotropin through selective deamidation
EP0075444B1 (de) * 1981-09-18 1992-12-23 Genentech, Inc. Verfahren und Produkte zur leichten mikrobiologischen Expression von DNS-Sequenzen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085036A1 (de) * 1982-01-18 1983-08-03 Monsanto Company Verfahren zur Verbesserung der Rindermilchproduktion
US4446235A (en) * 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
US5104806A (en) * 1987-03-12 1992-04-14 Amgen, Inc. Porcine growth hormone analogs encoding dna

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075444B1 (de) * 1981-09-18 1992-12-23 Genentech, Inc. Verfahren und Produkte zur leichten mikrobiologischen Expression von DNS-Sequenzen
WO1987001708A2 (en) * 1985-09-18 1987-03-26 The Upjohn Company Enhanced bioactivity of mammalian somatotropin through selective deamidation

Also Published As

Publication number Publication date
JPH04502762A (ja) 1992-05-21
AU4942790A (en) 1990-08-13
DK136991A (da) 1991-07-17
CA2005358A1 (en) 1990-07-19
WO1990008164A1 (en) 1990-07-26
KR910700264A (ko) 1991-03-14
EP0454730A1 (de) 1991-11-06
DK136991D0 (da) 1991-07-17

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