AU6264996A - Method for identifying alzheimer's disease therapeutics usin g transgenic animal models - Google Patents
Method for identifying alzheimer's disease therapeutics usin g transgenic animal modelsInfo
- Publication number
- AU6264996A AU6264996A AU62649/96A AU6264996A AU6264996A AU 6264996 A AU6264996 A AU 6264996A AU 62649/96 A AU62649/96 A AU 62649/96A AU 6264996 A AU6264996 A AU 6264996A AU 6264996 A AU6264996 A AU 6264996A
- Authority
- AU
- Australia
- Prior art keywords
- usin
- animal models
- transgenic animal
- disease therapeutics
- identifying alzheimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011820 transgenic animal model Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US486018 | 1983-04-18 | ||
US48653895A | 1995-06-07 | 1995-06-07 | |
US48601895A | 1995-06-07 | 1995-06-07 | |
US486538 | 1995-06-07 | ||
PCT/US1996/009679 WO1996040895A1 (fr) | 1995-06-07 | 1996-06-07 | Procede d'identification de therapies de la maladie d'alzheimer a l'aide de modeles animaux transgeniques |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6264996A true AU6264996A (en) | 1996-12-30 |
Family
ID=27048545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU62649/96A Abandoned AU6264996A (en) | 1995-06-07 | 1996-06-07 | Method for identifying alzheimer's disease therapeutics usin g transgenic animal models |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0832205A1 (fr) |
JP (1) | JP2001517065A (fr) |
AU (1) | AU6264996A (fr) |
CA (1) | CA2221986A1 (fr) |
WO (1) | WO1996040895A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999009150A1 (fr) * | 1996-08-15 | 1999-02-25 | Bayer Corporation | Methode permettant d'introduire des modifications dans un gene |
US7226730B1 (en) | 1997-02-26 | 2007-06-05 | The General Hospital Corporation | Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease |
JP4194664B2 (ja) | 1997-02-26 | 2008-12-10 | ザ ジェネラル ホスピタル コーポレイション | アルツハイマー病の処置または予防のために効果的な薬物をスクリーニングするためのトランスジェニック動物および細胞株 |
US6175057B1 (en) | 1997-10-08 | 2001-01-16 | The Regents Of The University Of California | Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy |
US6455757B1 (en) | 1997-10-08 | 2002-09-24 | The Regents Of The University Of California | Transgenic mice expressing human APP and TGF-β demonstrate cerebrovascular amyloid deposits |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6046381A (en) * | 1998-04-30 | 2000-04-04 | The Regents Of The University Of California | Apolipoprotein E transgenic mice and assay methods |
WO2000059297A2 (fr) * | 1999-04-06 | 2000-10-12 | Harrington Arthritis Research Center | Methodes permettant de suivre l'evolution de la maladie d'alzheimer et d'identifier des traitements au moyen de souris transgeniques |
SI1292187T1 (sl) * | 2000-06-20 | 2006-10-31 | Univ Toronto | Transgenski zivalski model nevrodegenerativnih motenj |
US7371920B2 (en) | 2000-06-20 | 2008-05-13 | The Governing Council Of The University Of Toronto | Transgenic mouse model of neurodegenerative disorders |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US7217262B2 (en) | 2003-01-17 | 2007-05-15 | The Procter & Gamble Co. | Absorbent article having stretchable fastening member |
KR100574544B1 (ko) * | 2004-04-01 | 2006-04-27 | 주식회사 뉴로테크 | 돌연변이 βCTF99를 발현하는 알츠하이머병 유발형질전환 마우스 |
JP2008523815A (ja) | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | 認知の改善における使用のためのヒト化アミロイドβ抗体 |
EP1999144A1 (fr) | 2006-03-16 | 2008-12-10 | VIB vzw | Mutations de promoteur qui augmentent l'expression de la protéine précurseur d'amyloïde |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
WO2013041577A1 (fr) | 2011-09-20 | 2013-03-28 | Vib Vzw | Procédés de diagnostic de la sclérose latérale amyotrophique et de la dégénérescence lobaire frontotemporale |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE286971T1 (de) * | 1991-01-21 | 2005-01-15 | Elan Pharm Inc | Prüfung und modell für alzheimers-krankheit |
WO1993007296A1 (fr) * | 1991-10-03 | 1993-04-15 | Indiana University Foundation | Procede pour depister la maladie d'alzheimer |
CA2127450C (fr) * | 1992-01-07 | 2007-04-17 | Samuel Wadsworth | Modeles d'animaux transgeniques pour la maladie d'alzheimer |
EP0561087B1 (fr) * | 1992-03-20 | 1999-08-04 | N.V. Innogenetics S.A. | Forme mutée du gène de la protéine du précurseur beta-amyloide |
US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
WO1994023049A2 (fr) * | 1993-04-02 | 1994-10-13 | The Johns Hopkins University | Introduction et expression de grandes sequences genomiques chez des animaux transgeniques |
CA2174429C (fr) * | 1993-10-27 | 2011-08-30 | Lisa C. Mcconlogue | Animaux transgeniques hebergeant un gene allele app presentant une mutation suedoise |
WO1995014769A1 (fr) * | 1993-11-29 | 1995-06-01 | University Of South Florida | Souris transgenique preparee a l'aide de chromosomes artificiels de levure et d'une recombinaison homologue |
DE69533583T2 (de) * | 1994-01-27 | 2005-10-06 | Regents of the University of Minnesota, Southeast, Minneapolis | Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit |
-
1996
- 1996-06-07 EP EP96921420A patent/EP0832205A1/fr not_active Withdrawn
- 1996-06-07 WO PCT/US1996/009679 patent/WO1996040895A1/fr not_active Application Discontinuation
- 1996-06-07 CA CA002221986A patent/CA2221986A1/fr not_active Abandoned
- 1996-06-07 JP JP50194697A patent/JP2001517065A/ja not_active Ceased
- 1996-06-07 AU AU62649/96A patent/AU6264996A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001517065A (ja) | 2001-10-02 |
WO1996040895A1 (fr) | 1996-12-19 |
CA2221986A1 (fr) | 1996-12-19 |
EP0832205A1 (fr) | 1998-04-01 |
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