AU607012B2 - Agents for treating high blood pressure and cardiac insufficiency - Google Patents
Agents for treating high blood pressure and cardiac insufficiency Download PDFInfo
- Publication number
- AU607012B2 AU607012B2 AU24438/88A AU2443888A AU607012B2 AU 607012 B2 AU607012 B2 AU 607012B2 AU 24438/88 A AU24438/88 A AU 24438/88A AU 2443888 A AU2443888 A AU 2443888A AU 607012 B2 AU607012 B2 AU 607012B2
- Authority
- AU
- Australia
- Prior art keywords
- blood pressure
- group
- agents
- tho
- cardiac insufficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000002253 acid Substances 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 125000000217 alkyl group Chemical group 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- -1 C 1 4 aikoxy Chemical group 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000005530 alkylenedioxy group Chemical group 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- ZRNKXJHEQKMWCH-UHFFFAOYSA-N 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1h-3-benzazepin-4-one;hydron;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CCN(C)CCCN1C(=O)CC2=CC(OC)=C(OC)C=C2CC1 ZRNKXJHEQKMWCH-UHFFFAOYSA-N 0.000 description 1
- 241001377084 Actites Species 0.000 description 1
- 102100028633 Cdc42-interacting protein 4 Human genes 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 101100001674 Emericella variicolor andI gene Proteins 0.000 description 1
- 101100213135 Escherichia coli (strain K12) ydaQ gene Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 101000766830 Homo sapiens Cdc42-interacting protein 4 Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101100400378 Mus musculus Marveld2 gene Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000282337 Nasua nasua Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 101150011375 Tab2 gene Proteins 0.000 description 1
- 101000857680 Xenopus laevis Runt-related transcription factor 1 Proteins 0.000 description 1
- 241000209149 Zea Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 125000005236 alkanoylamino group Chemical group 0.000 description 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229940116364 hard fat Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012332 laboratory investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Electrotherapy Devices (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3736866 | 1987-10-30 | ||
| DE19873736866 DE3736866A1 (de) | 1987-10-30 | 1987-10-30 | Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2443888A AU2443888A (en) | 1989-05-04 |
| AU607012B2 true AU607012B2 (en) | 1991-02-21 |
Family
ID=6339463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU24438/88A Ceased AU607012B2 (en) | 1987-10-30 | 1988-10-28 | Agents for treating high blood pressure and cardiac insufficiency |
Country Status (11)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10018401A1 (de) * | 2000-04-13 | 2001-10-25 | Boehringer Ingelheim Pharma | Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen |
| US20040138306A1 (en) | 2002-07-25 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure |
| DE60200160T2 (de) * | 2002-07-25 | 2004-11-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Cilobradine oder pharmazeutisch akzeptablen Salze zur Behandlung oder Prävention von Herzversagen |
| EP1762179A1 (en) | 2005-09-07 | 2007-03-14 | Boehringer Ingelheim Vetmedica Gmbh | Method for improving diagnostic quality in echocardiography |
| FR2894825B1 (fr) * | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
| EP2741735A1 (en) | 2011-08-12 | 2014-06-18 | Boehringer Ingelheim Vetmedica GmbH | Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline |
| EP2953612A1 (en) | 2013-02-11 | 2015-12-16 | Boehringer Ingelheim Vetmedica GmbH | Kit-of-parts |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0065229A1 (de) * | 1981-05-19 | 1982-11-24 | Dr. Karl Thomae GmbH | Neue Benzazepinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2639718C2 (de) * | 1976-09-03 | 1987-03-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel |
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
-
1987
- 1987-10-30 DE DE19873736866 patent/DE3736866A1/de not_active Withdrawn
-
1988
- 1988-10-15 EP EP19880117181 patent/EP0313945A3/de not_active Withdrawn
- 1988-10-15 EP EP91118481A patent/EP0471388B1/de not_active Expired - Lifetime
- 1988-10-15 DE DE91118481T patent/DE3882381D1/de not_active Expired - Fee Related
- 1988-10-28 HU HU885641A patent/HU203282B/hu not_active IP Right Cessation
- 1988-10-28 DK DK603688A patent/DK603688A/da not_active Application Discontinuation
- 1988-10-28 JP JP63272855A patent/JP2665357B2/ja not_active Expired - Fee Related
- 1988-10-28 KR KR1019880014066A patent/KR960011240B1/ko not_active Expired - Fee Related
- 1988-10-28 ZA ZA888090A patent/ZA888090B/xx unknown
- 1988-10-28 AU AU24438/88A patent/AU607012B2/en not_active Ceased
-
1991
- 1991-10-30 AT AT91118481T patent/ATE91418T1/de not_active IP Right Cessation
-
1993
- 1993-08-09 US US08/104,224 patent/US5516773A/en not_active Expired - Lifetime
-
1996
- 1996-09-19 HK HK175896A patent/HK175896A/xx not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0065229A1 (de) * | 1981-05-19 | 1982-11-24 | Dr. Karl Thomae GmbH | Neue Benzazepinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| AU551509B2 (en) * | 1981-05-19 | 1986-05-01 | Dr. Karl Thomae Gmbh | Benzazepine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0313945A3 (de) | 1990-12-05 |
| EP0471388A3 (de) | 1992-03-11 |
| ZA888090B (en) | 1990-07-25 |
| DE3882381D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-08-19 |
| JPH02138123A (ja) | 1990-05-28 |
| AU2443888A (en) | 1989-05-04 |
| KR960011240B1 (ko) | 1996-08-21 |
| HK175896A (en) | 1996-09-27 |
| HUT48464A (en) | 1989-06-28 |
| EP0471388B1 (de) | 1993-07-14 |
| EP0471388A2 (de) | 1992-02-19 |
| DK603688A (da) | 1989-05-01 |
| JP2665357B2 (ja) | 1997-10-22 |
| EP0313945A2 (de) | 1989-05-03 |
| DK603688D0 (da) | 1988-10-28 |
| ATE91418T1 (de) | 1993-07-15 |
| KR890006234A (ko) | 1989-06-12 |
| HU203282B (en) | 1991-07-29 |
| US5516773A (en) | 1996-05-14 |
| DE3736866A1 (de) | 1989-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |