AU597718B2 - Pharmaceutical composition comprising a phosphodiesterase inhibitor and a thromboxane a2 antagonist - Google Patents
Pharmaceutical composition comprising a phosphodiesterase inhibitor and a thromboxane a2 antagonist Download PDFInfo
- Publication number
- AU597718B2 AU597718B2 AU78296/87A AU7829687A AU597718B2 AU 597718 B2 AU597718 B2 AU 597718B2 AU 78296/87 A AU78296/87 A AU 78296/87A AU 7829687 A AU7829687 A AU 7829687A AU 597718 B2 AU597718 B2 AU 597718B2
- Authority
- AU
- Australia
- Prior art keywords
- thromboxane
- antagonist
- pharmaceutical composition
- ethyl
- series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000003769 thromboxane A2 receptor blocking agent Substances 0.000 title claims description 26
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 title claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 15
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title claims description 13
- -1 benzenesulphonamido- ethyl Chemical group 0.000 claims description 20
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 17
- 229960002768 dipyridamole Drugs 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 8
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- 206010003178 Arterial thrombosis Diseases 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 claims description 4
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims description 4
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- BWESROVQGZSBRX-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine Chemical class C1=NC=NC2=CC=CN=C21 BWESROVQGZSBRX-UHFFFAOYSA-N 0.000 claims description 2
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- 239000005557 antagonist Substances 0.000 description 9
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- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007966 viscous suspension Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863631294 DE3631294A1 (de) | 1986-09-13 | 1986-09-13 | Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung |
| DE3631294 | 1986-09-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7829687A AU7829687A (en) | 1988-03-17 |
| AU597718B2 true AU597718B2 (en) | 1990-06-07 |
Family
ID=6309586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU78296/87A Ceased AU597718B2 (en) | 1986-09-13 | 1987-09-11 | Pharmaceutical composition comprising a phosphodiesterase inhibitor and a thromboxane a2 antagonist |
Country Status (12)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0306846A3 (de) * | 1987-09-11 | 1990-05-02 | Dr. Karl Thomae GmbH | Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung |
| US5858694A (en) * | 1997-05-30 | 1999-01-12 | Cell Pathways, Inc. | Method for identifying compounds for inhibition of cancerous lesions |
| WO2001021259A2 (en) | 1999-09-21 | 2001-03-29 | Emory University | Use and compositions for treating platelet-related disorders using anagrelide |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU533193B2 (en) * | 1979-03-30 | 1983-11-10 | Borg-Warner Corporation | Pulse-width modulated inverter system |
| AU543568B2 (en) * | 1980-12-12 | 1985-04-26 | Dr. Karl Thomae Gmbh | Quinazoline and pyrido pyrimidine derivatives |
| AU547792B2 (en) * | 1980-12-27 | 1985-11-07 | Dr. Karl Thomae Gmbh | Pyrimido(5,4-d)pyrimidines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568676A (en) * | 1983-11-25 | 1986-02-04 | Thomas Jefferson University | Method of inhibiting aggregation using thromboxane synthetase inhibitor in combination with a cyclic AMP phosphodiesterase inhibitor |
-
1986
- 1986-09-13 DE DE19863631294 patent/DE3631294A1/de not_active Withdrawn
-
1987
- 1987-09-01 PH PH35759A patent/PH23553A/en unknown
- 1987-09-02 DE DE8787112773T patent/DE3777926D1/de not_active Expired - Lifetime
- 1987-09-02 ES ES198787112773T patent/ES2033755T3/es not_active Expired - Lifetime
- 1987-09-02 EP EP87112773A patent/EP0260527B1/de not_active Expired - Lifetime
- 1987-09-10 DK DK472487A patent/DK472487A/da not_active Application Discontinuation
- 1987-09-11 AU AU78296/87A patent/AU597718B2/en not_active Ceased
- 1987-09-11 ZA ZA876806A patent/ZA876806B/xx unknown
- 1987-09-11 JP JP62228239A patent/JPS6379838A/ja active Pending
- 1987-09-11 NZ NZ221779A patent/NZ221779A/xx unknown
- 1987-09-11 IL IL83872A patent/IL83872A0/xx unknown
- 1987-09-12 KR KR870010125A patent/KR880003624A/ko not_active Withdrawn
-
1992
- 1992-06-18 GR GR920401303T patent/GR3004969T3/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU533193B2 (en) * | 1979-03-30 | 1983-11-10 | Borg-Warner Corporation | Pulse-width modulated inverter system |
| AU543568B2 (en) * | 1980-12-12 | 1985-04-26 | Dr. Karl Thomae Gmbh | Quinazoline and pyrido pyrimidine derivatives |
| AU547792B2 (en) * | 1980-12-27 | 1985-11-07 | Dr. Karl Thomae Gmbh | Pyrimido(5,4-d)pyrimidines |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3777926D1 (de) | 1992-05-07 |
| AU7829687A (en) | 1988-03-17 |
| DE3631294A1 (de) | 1988-03-24 |
| DK472487A (da) | 1988-03-14 |
| NZ221779A (en) | 1990-03-27 |
| ZA876806B (en) | 1989-05-30 |
| DK472487D0 (da) | 1987-09-10 |
| IL83872A0 (en) | 1988-02-29 |
| EP0260527B1 (de) | 1992-04-01 |
| ES2033755T3 (es) | 1993-04-01 |
| KR880003624A (ko) | 1988-05-28 |
| PH23553A (en) | 1989-08-25 |
| GR3004969T3 (enrdf_load_stackoverflow) | 1993-04-28 |
| EP0260527A3 (en) | 1989-08-09 |
| EP0260527A2 (de) | 1988-03-23 |
| JPS6379838A (ja) | 1988-04-09 |
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