AU597446B2 - Imidazole derivatives and preparation thereof - Google Patents

Imidazole derivatives and preparation thereof Download PDF

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Publication number
AU597446B2
AU597446B2 AU81812/87A AU8181287A AU597446B2 AU 597446 B2 AU597446 B2 AU 597446B2 AU 81812/87 A AU81812/87 A AU 81812/87A AU 8181287 A AU8181287 A AU 8181287A AU 597446 B2 AU597446 B2 AU 597446B2
Authority
AU
Australia
Prior art keywords
group
lower alkyl
ring
pyridyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU81812/87A
Other languages
English (en)
Other versions
AU8181287A (en
Inventor
Yasushi Honma
Tetsuo Magaribuchi
Mine Takido
Hajime Tamaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of AU8181287A publication Critical patent/AU8181287A/en
Application granted granted Critical
Publication of AU597446B2 publication Critical patent/AU597446B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU81812/87A 1986-12-02 1987-11-26 Imidazole derivatives and preparation thereof Ceased AU597446B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP28751286 1986-12-02
JP62-080475 1987-03-31
JP8047587 1987-03-31
JP21581387 1987-08-28
JP62-215813 1987-08-28
JP61-287512 1987-08-28

Publications (2)

Publication Number Publication Date
AU8181287A AU8181287A (en) 1988-06-02
AU597446B2 true AU597446B2 (en) 1990-05-31

Family

ID=27303307

Family Applications (1)

Application Number Title Priority Date Filing Date
AU81812/87A Ceased AU597446B2 (en) 1986-12-02 1987-11-26 Imidazole derivatives and preparation thereof

Country Status (15)

Country Link
US (3) US5002945A (OSRAM)
EP (1) EP0270091B1 (OSRAM)
JP (1) JPH064623B2 (OSRAM)
KR (1) KR930004843B1 (OSRAM)
CN (1) CN1020902C (OSRAM)
AU (1) AU597446B2 (OSRAM)
DE (1) DE3782621T2 (OSRAM)
DK (1) DK631587A (OSRAM)
ES (1) ES2044901T3 (OSRAM)
FI (1) FI91754C (OSRAM)
FR (1) FR2607502B1 (OSRAM)
GR (1) GR3006257T3 (OSRAM)
HU (2) HU204812B (OSRAM)
IL (1) IL84554A (OSRAM)
TW (1) TW203048B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634711A (en) * 1985-08-02 1987-01-06 Smithkline Beckman Corporation Pyridylalkyl imidazole-2-thiols
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
KR910021381A (ko) * 1990-02-20 1991-12-20 모리 히데오 4-3급 부틸이미다졸 유도체, 및 이의 제조방법 및 용도
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
CA2036147A1 (en) * 1990-06-29 1991-12-30 Hiroki Tomioka A 1-pyridylimidazole derivative and its production and use
MY110439A (en) * 1991-02-07 1998-05-30 Ishihara Sangyo Kaisha N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms
US5252590A (en) * 1991-06-28 1993-10-12 Sumitomo Chemical Company, Limited 1-pyridylimidazole derivative
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
DE19541146A1 (de) * 1995-10-25 1997-04-30 Schering Ag Imidazolderivate und deren Verwendung als Stickstoffmonoxid-Synthase-Inhibitoren
WO2005041961A1 (en) 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
BRPI0511504A (pt) * 2004-05-26 2008-01-22 Eisai R&D Man Co Ltd composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides
CA2583326A1 (en) * 2004-10-08 2006-04-13 Takeda Pharmaceutical Company Limited Receptor function regulating agent
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
ES2529648T3 (es) 2007-08-31 2015-02-24 Eisai R&D Management Co., Ltd. Compuesto policíclico

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3426384A (en) * 1983-10-18 1985-04-26 Farmos-Yhtyma Oy Substituted-2-mercapto-imidazoles
AU6055886A (en) * 1985-08-02 1987-02-05 Smithkline Beckman Corporation Pyridylalkyl substituted imidazole-2-thiols
AU7246387A (en) * 1986-05-06 1987-11-12 Merrell Dow Pharmaceuticals Inc. Novel dopamine beta hydroxylase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (OSRAM) * 1968-10-21 1971-06-03
IN148930B (OSRAM) * 1977-09-19 1981-07-25 Hoffmann La Roche
EP0004648B1 (de) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Neue Mercaptoimidazolderivate, Verfahren zu deren Herstellung, Mercaptoimidazolderivate zur Behandlung entzündlicher Erkrankungen und diese enthaltende pharmazeutische Präparate
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
DE3369845D1 (en) * 1982-12-20 1987-04-02 Merck & Co Inc 5-(amino or substituted amino) imidazoles
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8417171D0 (en) * 1984-07-05 1984-08-08 Beecham Group Plc Compounds
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4600430A (en) * 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
US4591377A (en) * 1985-09-10 1986-05-27 Stauffer Chemical Company Herbicidal esters of 2-bromo-4-methylimidazole-5-carboxylic acid
JPH0674273B2 (ja) * 1986-06-19 1994-09-21 日産化学工業株式会社 イミダゾ−ルスルホンアミド誘導体、製法および除草剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3426384A (en) * 1983-10-18 1985-04-26 Farmos-Yhtyma Oy Substituted-2-mercapto-imidazoles
AU6055886A (en) * 1985-08-02 1987-02-05 Smithkline Beckman Corporation Pyridylalkyl substituted imidazole-2-thiols
AU7246387A (en) * 1986-05-06 1987-11-12 Merrell Dow Pharmaceuticals Inc. Novel dopamine beta hydroxylase inhibitors

Also Published As

Publication number Publication date
EP0270091B1 (en) 1992-11-11
KR880007477A (ko) 1988-08-27
EP0270091A1 (en) 1988-06-08
ES2044901T3 (es) 1994-01-16
DK631587D0 (da) 1987-12-01
DE3782621D1 (de) 1992-12-17
AU8181287A (en) 1988-06-02
HU201751B (en) 1990-12-28
FI91754B (fi) 1994-04-29
CN1020902C (zh) 1993-05-26
DK631587A (da) 1988-06-03
HUT49128A (en) 1989-08-28
HU905023D0 (en) 1991-01-28
FR2607502B1 (fr) 1990-01-19
FI875102L (fi) 1988-06-03
KR930004843B1 (ko) 1993-06-09
CN87108111A (zh) 1988-09-28
FI875102A0 (fi) 1987-11-18
FI91754C (fi) 1994-08-10
IL84554A (en) 1992-03-29
US5002945A (en) 1991-03-26
JPH01131175A (ja) 1989-05-24
US4996217A (en) 1991-02-26
IL84554A0 (en) 1988-04-29
US5053417A (en) 1991-10-01
JPH064623B2 (ja) 1994-01-19
DE3782621T2 (de) 1993-04-22
GR3006257T3 (OSRAM) 1993-06-21
TW203048B (OSRAM) 1993-04-01
HU204812B (en) 1992-02-28
FR2607502A1 (fr) 1988-06-03

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