AU594099B2 - Stable soluble 1,2-diaminocyclohexane platinum complexes - Google Patents

Stable soluble 1,2-diaminocyclohexane platinum complexes Download PDF

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Publication number
AU594099B2
AU594099B2 AU65748/86A AU6574886A AU594099B2 AU 594099 B2 AU594099 B2 AU 594099B2 AU 65748/86 A AU65748/86 A AU 65748/86A AU 6574886 A AU6574886 A AU 6574886A AU 594099 B2 AU594099 B2 AU 594099B2
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AU
Australia
Prior art keywords
complex
platinum
diaminocyclohexane
trans
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU65748/86A
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English (en)
Other versions
AU6574886A (en
Inventor
Devinder Singh Gill
Kenneth James Mcgrath
Paul Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Andrulis Research Corp
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Andrulis Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrulis Research Corp filed Critical Andrulis Research Corp
Publication of AU6574886A publication Critical patent/AU6574886A/en
Application granted granted Critical
Publication of AU594099B2 publication Critical patent/AU594099B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU65748/86A 1985-12-26 1986-11-27 Stable soluble 1,2-diaminocyclohexane platinum complexes Ceased AU594099B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US813451 1985-12-26
US06/813,451 US4680308A (en) 1985-12-26 1985-12-26 Stable soluble 1,2-diaminocyclohexane platinum complexes

Publications (2)

Publication Number Publication Date
AU6574886A AU6574886A (en) 1987-07-02
AU594099B2 true AU594099B2 (en) 1990-03-01

Family

ID=25212407

Family Applications (1)

Application Number Title Priority Date Filing Date
AU65748/86A Ceased AU594099B2 (en) 1985-12-26 1986-11-27 Stable soluble 1,2-diaminocyclohexane platinum complexes

Country Status (12)

Country Link
US (1) US4680308A (enExample)
EP (1) EP0228298B1 (enExample)
JP (1) JPH0717666B2 (enExample)
AT (1) ATE73813T1 (enExample)
AU (1) AU594099B2 (enExample)
CA (1) CA1261863A (enExample)
DE (1) DE3684435D1 (enExample)
ES (1) ES2039204T3 (enExample)
GR (1) GR3004970T3 (enExample)
IE (1) IE59692B1 (enExample)
IL (1) IL80620A (enExample)
ZA (1) ZA869649B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602589B2 (en) * 1987-06-23 1990-10-18 American Cyanamid Company Synthesis of cisplatinum analogs

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5011959A (en) * 1986-11-17 1991-04-30 The Board Of Regents, The University Of Texas System 1,2-diaminocyclohexane-platinum complexes with antitumor activity
US4904809A (en) * 1987-09-25 1990-02-27 Ss Pharmaceutical Co., Ltd. Platinum complex
US4931553A (en) * 1988-05-11 1990-06-05 Gill Devinder S Platinum-polymer complexes and their use as antitumor agents
US5035878A (en) * 1988-09-12 1991-07-30 University Of Rochester Use of dithiocarbamates to counteract myelosuppression
US5294430A (en) * 1988-09-12 1994-03-15 University Of Rochester Use of dithiocarbamates to treat myelosuppression
US5187193A (en) * 1988-09-12 1993-02-16 University Of Rochester Method for stimulating transplanted bone marrow cells
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
JP3154399B2 (ja) * 1996-07-04 2001-04-09 デビオファーム エス．アー． 白金化合物の製造方法
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
CN102603805A (zh) * 2012-02-14 2012-07-25 昆明贵研药业有限公司 具有抗肿瘤活性的铂（ii）配合物及其制备方法
US9768463B2 (en) 2012-07-27 2017-09-19 Lockheed Martin Advanced Energy Storage, Llc Aqueous redox flow batteries comprising metal ligand coordination compounds
US10164284B2 (en) 2012-07-27 2018-12-25 Lockheed Martin Energy, Llc Aqueous redox flow batteries featuring improved cell design characteristics
US9382274B2 (en) * 2012-07-27 2016-07-05 Lockheed Martin Advanced Energy Storage, Llc Aqueous redox flow batteries featuring improved cell design characteristics
EP3224266B1 (en) 2014-11-26 2021-03-03 Lockheed Martin Energy, LLC Metal complexes of substituted catecholates and redox flow batteries containing the same
US10253051B2 (en) 2015-03-16 2019-04-09 Lockheed Martin Energy, Llc Preparation of titanium catecholate complexes in aqueous solution using titanium tetrachloride or titanium oxychloride
US10644342B2 (en) 2016-03-03 2020-05-05 Lockheed Martin Energy, Llc Coordination complexes containing monosulfonated catecholate ligands and methods for producing the same
US10316047B2 (en) 2016-03-03 2019-06-11 Lockheed Martin Energy, Llc Processes for forming coordination complexes containing monosulfonated catecholate ligands
US9938308B2 (en) 2016-04-07 2018-04-10 Lockheed Martin Energy, Llc Coordination compounds having redox non-innocent ligands and flow batteries containing the same
US10343964B2 (en) 2016-07-26 2019-07-09 Lockheed Martin Energy, Llc Processes for forming titanium catechol complexes
US10377687B2 (en) 2016-07-26 2019-08-13 Lockheed Martin Energy, Llc Processes for forming titanium catechol complexes
US10065977B2 (en) 2016-10-19 2018-09-04 Lockheed Martin Advanced Energy Storage, Llc Concerted processes for forming 1,2,4-trihydroxybenzene from hydroquinone
US10930937B2 (en) 2016-11-23 2021-02-23 Lockheed Martin Energy, Llc Flow batteries incorporating active materials containing doubly bridged aromatic groups
US10497958B2 (en) 2016-12-14 2019-12-03 Lockheed Martin Energy, Llc Coordinatively unsaturated titanium catecholate complexes and processes associated therewith
US10741864B2 (en) 2016-12-30 2020-08-11 Lockheed Martin Energy, Llc Aqueous methods for forming titanium catecholate complexes and associated compositions
US10320023B2 (en) 2017-02-16 2019-06-11 Lockheed Martin Energy, Llc Neat methods for forming titanium catecholate complexes and associated compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137245A (en) * 1975-07-22 1979-01-30 The Miranol Chemical Company, Inc. Nitrogenous condensation products
US4200583A (en) * 1977-09-12 1980-04-29 Yoshinori Kidani New platinum complex
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2166076A (en) * 1936-02-27 1939-07-11 Baker & Co Inc Platinum metal compounds and methods of making them
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
US4137248A (en) * 1977-08-29 1979-01-30 The United States Of America As Represented By The Department Of Health, Education And Welfare Compound, 4-carboxyphthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof
JPS5472780A (en) * 1977-11-22 1979-06-11 Fuji Photo Film Co Ltd Stabilizing method for organic basic substance to light
JPS59112995A (ja) * 1982-12-21 1984-06-29 Shionogi & Co Ltd 新規グリコ−ル酸白金錯体
IL71804A (en) * 1983-05-10 1989-06-30 Andrulis Res Corp Bis-(platinum diamine)complexes and antitumor pharmaceutical compositions containing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137245A (en) * 1975-07-22 1979-01-30 The Miranol Chemical Company, Inc. Nitrogenous condensation products
US4200583A (en) * 1977-09-12 1980-04-29 Yoshinori Kidani New platinum complex
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602589B2 (en) * 1987-06-23 1990-10-18 American Cyanamid Company Synthesis of cisplatinum analogs

Also Published As

Publication number Publication date
ES2039204T3 (es) 1993-09-16
GR3004970T3 (enExample) 1993-04-28
ZA869649B (en) 1987-08-26
US4680308A (en) 1987-07-14
EP0228298A2 (en) 1987-07-08
IE862951L (en) 1987-06-26
IL80620A0 (en) 1987-02-27
JPH0717666B2 (ja) 1995-03-01
EP0228298B1 (en) 1992-03-18
JPS62158297A (ja) 1987-07-14
DE3684435D1 (de) 1992-04-23
EP0228298A3 (en) 1987-12-02
ATE73813T1 (de) 1992-04-15
AU6574886A (en) 1987-07-02
IE59692B1 (en) 1994-03-23
CA1261863A (en) 1989-09-26
IL80620A (en) 1990-12-23

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired