AU587426B2 - Peptide amino-alcohol derivatives inhibiting renin and acid proteases, process for preparation and application in therapy - Google Patents

Peptide amino-alcohol derivatives inhibiting renin and acid proteases, process for preparation and application in therapy

Info

Publication number
AU587426B2
AU587426B2 AU54100/86A AU5410086A AU587426B2 AU 587426 B2 AU587426 B2 AU 587426B2 AU 54100/86 A AU54100/86 A AU 54100/86A AU 5410086 A AU5410086 A AU 5410086A AU 587426 B2 AU587426 B2 AU 587426B2
Authority
AU
Australia
Prior art keywords
therapy
preparation
application
alcohol derivatives
peptide amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54100/86A
Other languages
English (en)
Other versions
AU5410086A (en
Inventor
Remy Guegan
Colette Lacour
Dino Nisato
Jean Wagnon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8502763A external-priority patent/FR2577931B1/fr
Priority claimed from FR8511728A external-priority patent/FR2585708B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of AU5410086A publication Critical patent/AU5410086A/en
Application granted granted Critical
Publication of AU587426B2 publication Critical patent/AU587426B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU54100/86A 1985-02-26 1986-02-26 Peptide amino-alcohol derivatives inhibiting renin and acid proteases, process for preparation and application in therapy Ceased AU587426B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8502763A FR2577931B1 (fr) 1985-02-26 1985-02-26 Derives aminodiols peptidiques inhibiteurs de la renine et des proteases acides, leur procede de preparation et leur application en therapeutique
FR8511728A FR2585708B1 (fr) 1985-07-31 1985-07-31 Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
FR8502763 1985-07-31
FR8511728 1985-07-31

Publications (2)

Publication Number Publication Date
AU5410086A AU5410086A (en) 1986-09-04
AU587426B2 true AU587426B2 (en) 1989-08-17

Family

ID=26224394

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54100/86A Ceased AU587426B2 (en) 1985-02-26 1986-02-26 Peptide amino-alcohol derivatives inhibiting renin and acid proteases, process for preparation and application in therapy

Country Status (9)

Country Link
EP (1) EP0214209A1 (pt)
KR (1) KR860006487A (pt)
AU (1) AU587426B2 (pt)
DK (1) DK89286A (pt)
ES (1) ES8900018A1 (pt)
GR (1) GR860532B (pt)
NZ (1) NZ215282A (pt)
PT (1) PT82077B (pt)
WO (1) WO1986004901A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
IL83663A0 (en) * 1986-10-27 1988-01-31 Robins Co Inc A H Preparation of 3-pyrrolidinols
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions
DE3721855A1 (de) * 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
DE4136443A1 (de) * 1991-11-06 1993-05-13 Boehringer Ingelheim Int Expression der reifen proteinase 2a, ihre partielle reinigung und bereitstellung kompetitiv wirkender substrate
ZA991319B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia.
EP1346983A3 (en) * 1998-02-20 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia
TW536538B (en) 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
JP6430936B2 (ja) * 2012-07-24 2018-11-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 関節症の処置のためのヒドロキシスタチン誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate

Also Published As

Publication number Publication date
AU5410086A (en) 1986-09-04
ES552407A0 (es) 1988-11-16
EP0214209A1 (fr) 1987-03-18
KR860006487A (ko) 1986-09-11
WO1986004901A1 (fr) 1986-08-28
DK89286D0 (da) 1986-02-26
ES8900018A1 (es) 1988-11-16
NZ215282A (en) 1989-08-29
PT82077B (fr) 1987-09-25
GR860532B (en) 1986-06-24
PT82077A (fr) 1986-03-01
DK89286A (da) 1986-08-27

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